ENSDARG00000030173


Danio rerio

Features
Gene ID: ENSDARG00000030173
  
Biological name :traf2a
  
Synonyms : Tnf receptor-associated factor 2a / traf2a
  
Possible biological names infered from orthology : P39429 / Q12933 / TNF receptor associated factor 2 / TRAF2
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 28755475
Gene end: 28767636
  
Corresponding Affymetrix probe sets: DrAffx.2.84.A1_at (Zebrafish Array)   DrAffx.2.84.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000043465
Ensembl peptide - ENSDARP00000130551
NCBI entrez gene - 564295     See in Manteia.
swissprot - A0A0R4ICA8
swissprot - E7EXH5
ZFIN ID - ZDB-GENE-071120-2
Ensembl - ENSDARG00000030173
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TRAF2ENSGALG00000042838Gallus gallus
 TRAF2ENSG00000127191Homo sapiens
 Traf2ENSMUSG00000026942Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
traf2b / Tnf receptor-associated factor 2bENSDARG0000010103655
unm_sa808 / un-named sa808 / TRAF2* / Q12933* / TNF receptor associated factor 2*ENSDARG0000007837841
traf1 / TNF receptor-associated factor 1 / P39428* / Q13077*ENSDARG0000006948232
traf3 / TNF receptor-associated factor 3 / Q13114* / Q60803*ENSDARG0000002200030
traf4a / tnf receptor-associated factor 4a / TRAF4* / Q61382* / Q9BUZ4* / TNF receptor associated factor 4*ENSDARG0000000396324
traf4b / tnf receptor-associated factor 4bENSDARG0000003896422
traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*ENSDARG0000002805822
traf5 / Tnf receptor-associated factor 5 / O00463*ENSDARG0000001724012


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR001841  Zinc finger, RING-type
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR027133  TNF receptor-associated factor 2
 IPR032070  TNF receptor-associated factor, BIRC3 binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
Dimerization of procaspase-8
TNF signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018569 tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / P25118* / TNF receptor superfamily member 1A*  / reaction / complex
 ENSDARG00000013598 tnfb / tumor necrosis factor b (TNF superfamily, member 2) / LTA* / TNF* / P01375* / P06804* / P09225* / P01374* / lymphotoxin A* / lymphotoxin alpha* / tumor necrosis factor*  / reaction / complex
 ENSDARG00000074060 map3k14a / mitogen-activated protein kinase kinase kinase 14a / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*  / complex / reaction
 ENSDARG00000036057 tradd / Q9I9N5 / tnfrsf1a-associated via death domain / Q15628* / Q3U0V2*  / complex / reaction
 ENSDARG00000070165 tnfrsf1b / tumor necrosis factor receptor superfamily, member 1B / P20333* / P25119* / TNF receptor superfamily member 1B*  / reaction / complex
 ENSDARG00000103021 fadd / Fas (tnfrsf6)-associated via death domain / Q13158* / Fas associated via death domain*  / complex / reaction
 ENSDARG00000012945 tnfsf13b / TNF superfamily member 13b / Q9Y275*  / complex
 ENSDARG00000030173 traf2a / Tnf receptor-associated factor 2a / TRAF2* / P39429* / Q12933* / TNF receptor associated factor 2*  / reaction / complex
 ENSDARG00000068141 tnfsf11 / TNF superfamily member 11 / O14788* / O35235* / tumor necrosis factor (ligand) superfamily, member 11*  / reaction / complex
 ENSDARG00000055966 cflara / CASP8 and FADD-like apoptosis regulator a / CFLAR* / O35732* / O15519* / CASP8 and FADD like apoptosis regulator* / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apop...  / complex / reaction
 ENSDARG00000054968 cd40 / CD40 molecule, TNF receptor superfamily member 5 / P27512* / O35305* / P25942* / Q9Y6Q6* / TNFRSF11A* / CD40 molecule* / TNF receptor superfamily member 11a* / Tumor necrosis factor ...  / complex / reaction
 ENSDARG00000022000 traf3 / TNF receptor-associated factor 3 / Q13114* / Q60803*  / reaction / complex
 ENSDARG00000087804 tnfrsf11a / tumor necrosis factor receptor superfamily, member 11a, NFKB activator / CD40* / Q9Y6Q6* / O35305* / P25942* / P27512* / CD40 molecule* / TNF receptor superfamily member 11a* / ...  / complex / reaction
 ENSDARG00000090301 usp48 / ubiquitin specific peptidase 48 / Q3V0C5* / Q86UV5*  / complex
 ENSDARG00000044619 birc2 / baculoviral IAP repeat containing 2 / BIRC3* / Q13489* / Q13490* / Q62210* / baculoviral IAP repeat containing 3* / Baculoviral IAP repeat-containing protein 2 *  / complex / reaction
 ENSDARG00000014770 usp4 / ubiquitin specific peptidase 4 (proto-oncogene) / P35123* / Q13107* / ubiquitin specific peptidase 4*  / complex / reaction
 ENSDARG00000060058 cylda / cylindromatosis (turban tumor syndrome), a / CYLD* / Q80TQ2* / Q9NQC7* / CYLD lysine 63 deubiquitinase* / Ubiquitin carboxyl-terminal hydrolase CYLD *  / complex






 

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