ENSGALG00000042838


Gallus gallus

Features
Gene ID: ENSGALG00000042838
  
Biological name :TRAF2
  
Synonyms : TNF receptor associated factor 2 / TRAF2
  
Possible biological names infered from orthology : P39429 / Q12933
  
Species: Gallus gallus
  
Chr. number: 17
Strand: -1
Band:
Gene start: 1022634
Gene end: 1038699
  
Corresponding Affymetrix probe sets: Gga.11660.1.S1_at (Chicken Array)   GgaAffx.22768.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046957
NCBI entrez gene - 417287     See in Manteia.
RefSeq - XM_015279619
RefSeq - XM_015279621
RefSeq - XM_015279622
RefSeq - XM_015279623
RefSeq - XM_015279618
swissprot - A0A1D5P2Q9
Ensembl - ENSGALG00000042838
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 traf2aENSDARG00000030173Danio rerio
 unm_sa808ENSDARG00000078378Danio rerio
 TRAF2ENSG00000127191Homo sapiens
 Traf2ENSMUSG00000026942Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRAF1 / TNF receptor associated factor 1 / P39428* / Q13077*ENSGALG0000000158334
TRAF5 / TNF receptor associated factor 5 / O00463*ENSGALG0000000986430
TRAF3 / TNF receptor associated factor 3 / Q13114* / Q60803*ENSGALG0000001138929
TRAF4 / TNF receptor associated factor 4 / Q61382* / Q9BUZ4*ENSGALG0000000398724
TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*ENSGALG0000000793222


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR001841  Zinc finger, RING-type
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR027133  TNF receptor-associated factor 2
 IPR032070  TNF receptor-associated factor, BIRC3 binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002726 positive regulation of T cell cytokine production IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IEA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0032743 positive regulation of interleukin-2 production IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0034622 cellular protein-containing complex assembly IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0051023 regulation of immunoglobulin secretion IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0070207 protein homotrimerization IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 biological_processGO:0071732 cellular response to nitric oxide IEA
 biological_processGO:0090073 positive regulation of protein homodimerization activity IEA
 biological_processGO:0097300 programmed necrotic cell death IEA
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:1903721 positive regulation of I-kappaB phosphorylation IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0012506 vesicle membrane IEA
 cellular_componentGO:0035631 CD40 receptor complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0097057 TRAF2-GSTP1 complex IEA
 cellular_componentGO:1990597 AIP1-IRE1 complex IEA
 cellular_componentGO:1990604 IRE1-TRAF2-ASK1 complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005174 CD40 receptor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0031996 thioesterase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046625 sphingolipid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
Dimerization of procaspase-8


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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