ENSGALG00000011389


Gallus gallus

Features
Gene ID: ENSGALG00000011389
  
Biological name :TRAF3
  
Synonyms : TNF receptor associated factor 3 / TRAF3
  
Possible biological names infered from orthology : Q13114 / Q60803
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 49931771
Gene end: 49957338
  
Corresponding Affymetrix probe sets: Gga.12655.1.S1_at (Chicken Array)   Gga.12655.2.S1_at (Chicken Array)   Gga.14306.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000018553
NCBI entrez gene - 423471     See in Manteia.
RefSeq - XM_004936343
RefSeq - XM_004936344
RefSeq - XM_015287818
RefSeq - XM_015287819
RefSeq - XM_015287820
RefSeq - XM_015287821
RefSeq - XM_015287822
RefSeq - XM_015287823
RefSeq - XM_015287825
RefSeq - XM_015287826
RefSeq - XM_015287827
RefSeq - XM_004936341
swissprot - E1BW11
Ensembl - ENSGALG00000011389
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 traf3ENSDARG00000022000Danio rerio
 TRAF3ENSG00000131323Homo sapiens
 Traf3ENSMUSG00000021277Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRAF5 / TNF receptor associated factor 5 / O00463*ENSGALG0000000986440
TRAF2 / TNF receptor associated factor 2 / P39429* / Q12933*ENSGALG0000004283832
TRAF1 / TNF receptor associated factor 1 / P39428* / Q13077*ENSGALG0000000158329
TRAF4 / TNF receptor associated factor 4 / Q61382* / Q9BUZ4*ENSGALG0000000398722
TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*ENSGALG0000000793221


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR001841  Zinc finger, RING-type
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027128  TNF receptor-associated factor 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001817 regulation of cytokine production IEA
 biological_processGO:0002224 toll-like receptor signaling pathway IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008063 Toll signaling pathway IEA
 biological_processGO:0030162 regulation of proteolysis IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032648 regulation of interferon-beta production IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050688 regulation of defense response to virus IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0035631 CD40 receptor complex IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0031996 thioesterase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ovarian tumor domain proteases
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006415 CD40LG / Q9I8D8 / CD40 ligand CD40 ligand, membrane form CD40 ligand, soluble form / P27548* / P29965* / CD40 ligand*  / complex / reaction
 ENSGALG00000009840 TBK1 / TANK binding kinase 1 / Q9UHD2* / Q9WUN2*  / reaction / complex
 ENSGALG00000017186 BIRC2 / BIRC3* / Q62210* / Q13489* / Q13490* / baculoviral IAP repeat containing 2* / baculoviral IAP repeat containing 3* / Baculoviral IAP repeat-containing protein 2 *  / complex / reaction
 ENSGALG00000011389 TRAF3 / TNF receptor associated factor 3 / Q13114* / Q60803*  / reaction / complex
 ENSGALG00000007015 CD40 / tumor necrosis factor receptor superfamily member 5 precursor / P25942* / P27512* / CD40 molecule* / Tumor necrosis factor receptor superfamily member 5 *  / reaction / complex
 ENSGALG00000016852 TNFSF13B / Q9WU72* / Q9Y275* / TNF superfamily member 13b* / tumor necrosis factor (ligand) superfamily, member 13b*  / complex
 ENSGALG00000011131 TANK / TRAF family member associated NFKB activator / P70347* / Q92844* / Mus musculus TRAF family member-associated Nf-kappa B activator (Tank), transcript variant 4, mRNA.*  / complex / reaction
 ENSGALG00000026850 TICAM1 / TIR domain-containing adapter molecule 1 / Q80UF7* / Q8IUC6* / toll like receptor adaptor molecule 1*  / reaction / complex
 ENSGALG00000039140 CD14 / monocyte differentiation antigen CD14 precursor / P10810* / P08571* / CD14 molecule* / Monocyte differentiation antigen CD14 *  / reaction / complex
 ENSGALG00000032701 LY96 / lymphocyte antigen 96 / Q9JHF9* / Q9Y6Y9*  / complex / reaction






 

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