ENSGALG00000026850


Gallus gallus

Features
Gene ID: ENSGALG00000026850
  
Biological name :TICAM1
  
Synonyms : TICAM1 / TIR domain-containing adapter molecule 1
  
Possible biological names infered from orthology : Q80UF7 / Q8IUC6 / toll like receptor adaptor molecule 1
  
Species: Gallus gallus
  
Chr. number: 28
Strand: 1
Band:
Gene start: 4877060
Gene end: 4879564
  
Corresponding Affymetrix probe sets: Gga.12009.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000064452
Ensembl peptide - ENSGALP00000041887
NCBI entrez gene - 100008585     See in Manteia.
RefSeq - XM_015300025
RefSeq - NM_001081506
RefSeq Peptide - NP_001074975
swissprot - R4GIF2
swissprot - A0A1L1S012
Ensembl - ENSGALG00000026850
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ticam1ENSDARG00000102493Danio rerio
 Q8IUC6ENSG00000127666Homo sapiens
 Q80UF7ENSMUSG00000047123Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR025735  RHIM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0045087 innate immune response IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA


Pathways (from Reactome)
Pathway description
via Death Receptors in the presence of ligand
MyD88-independent TLR4 cascade
TRIF-mediated programmed cell death
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003595 SARM1 / sterile alpha and TIR motif containing 1 / Q6PDS3* / Q6SZW1* / Sterile alpha and TIR motif-containing protein 1 *  / reaction / complex
 ENSGALG00000016284 TAB3 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3 / Q571K4* / Q8N5C8* / TGF-beta activated kinase 1/MAP3K7 binding protein 3*  / complex / reaction
 ENSGALG00000012356 TAB2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q99K90* / Q9NYJ8* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / reaction / complex
 ENSGALG00000015596 MAP3K7 / mitogen-activated protein kinase kinase kinase 7 / O43318* / Q62073*  / complex / reaction
 ENSGALG00000011131 TANK / TRAF family member associated NFKB activator / P70347* / Q92844* / Mus musculus TRAF family member-associated Nf-kappa B activator (Tank), transcript variant 4, mRNA.*  / reaction / complex
 ENSGALG00000012150 TAB1 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1 / Q15750* / Q8CF89* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 *  / complex / reaction
 ENSGALG00000009840 TBK1 / TANK binding kinase 1 / Q9UHD2* / Q9WUN2*  / complex / reaction
 ENSGALG00000032701 LY96 / lymphocyte antigen 96 / Q9JHF9* / Q9Y6Y9*  / complex / reaction
 ENSGALG00000011389 TRAF3 / TNF receptor associated factor 3 / Q13114* / Q60803*  / complex / reaction
 ENSGALG00000012827 RIPK1 / receptor interacting serine/threonine kinase 1 / Q13546* / Q60855* / Receptor-interacting serine/threonine-protein kinase 1 *  / complex / reaction
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / reaction / complex
 ENSGALG00000026850 TICAM1 / TIR domain-containing adapter molecule 1 / Q80UF7* / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000039140 CD14 / monocyte differentiation antigen CD14 precursor / P10810* / P08571* / CD14 molecule* / Monocyte differentiation antigen CD14 *  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction / complex
 ENSGALG00000007625 FADD / Fas associated via death domain / Q13158* / Q61160* / FAS-associated death domain protein *  / complex / reaction






 

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