ENSGALG00000015596


Gallus gallus

Features
Gene ID: ENSGALG00000015596
  
Biological name :MAP3K7
  
Synonyms : MAP3K7 / mitogen-activated protein kinase kinase kinase 7
  
Possible biological names infered from orthology : O43318 / Q62073
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 75357084
Gene end: 75404586
  
Corresponding Affymetrix probe sets: Gga.12434.1.S1_at (Chicken Array)   Gga.13158.1.S1_at (Chicken Array)   Gga.17079.1.S1_s_at (Chicken Array)   GgaAffx.24722.1.S1_at (Chicken Array)   GgaAffx.24722.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000025101
Ensembl peptide - ENSGALP00000049873
Ensembl peptide - ENSGALP00000043939
NCBI entrez gene - 421808     See in Manteia.
RefSeq - XM_419832
RefSeq - XM_015284684
RefSeq - XM_015284685
RefSeq - XM_015284686
RefSeq - XM_015284677
RefSeq - XM_015284678
RefSeq - XM_015284679
RefSeq - XM_015284681
RefSeq - XM_015284682
RefSeq - XM_015284683
swissprot - E1C063
swissprot - A0A1D5PAV9
swissprot - A0A1D5NUC4
Ensembl - ENSGALG00000015596
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k7ENSDARG00000020469Danio rerio
 MAP3K7ENSG00000135341Homo sapiens
 Map3k7ENSMUSG00000028284Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP3K9 / mitogen-activated protein kinase kinase kinase 9 / P80192* / Q3U1V8*ENSGALG0000003732624
MAP3K21 / mitogen-activated protein kinase kinase kinase 21 / Q5TCX8* / Q8VDG6*ENSGALG0000001100823
MAP3K13 / mitogen-activated protein kinase kinase kinase 13 / O43283* / Q1HKZ5*ENSGALG0000000665519
TNNI3K / Q59H18* / Q5GIG6* / FPGT-TNNI3K* / FPGT-TNNI3K readthrough* / TNNI3 interacting kinase*ENSGALG0000001135316
MAP3K20 / mitogen-activated protein kinase kinase kinase 20 / Q9ESL4* / Q9NYL2*ENSGALG0000003523716
ILK / integrin linked kinase / O55222* / Q13418* / Integrin-linked protein kinase *ENSGALG0000003164211
MOS / P10741 / Serine/threonine-protein kinase mos / P00540* / MOS proto-oncogene, serine/threonine kinase*ENSGALG0000004208211
Q12852* / Q60700* / MAP3K12* / mitogen-activated protein kinase kinase kinase 12* / Mus musculus mitogen-activated protein kinase kinase kinase 12 (Map3k12), transcript variant 3, mRNA.*ENSGALG000000315728


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017421  Mitogen-activated protein (MAP) kinase kinase kinase 7
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0002726 positive regulation of T cell cytokine production IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IEA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0010536 positive regulation of activation of Janus kinase activity IMP
 biological_processGO:0032743 positive regulation of interleukin-2 production IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0043966 histone H3 acetylation IEA
 biological_processGO:0051403 stress-activated MAPK cascade IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA
 cellular_componentGO:0008385 IkappaB kinase complex IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
Ca2+ pathway
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004398 CARD11 / caspase recruitment domain family member 11 / Q8CIS0* / Q9BXL7* / Caspase recruitment domain-containing protein 11 *  / complex / reaction
 ENSGALG00000005621 CAMK2A / calcium/calmodulin-dependent protein kinase type II subunit alpha / P11798* / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / complex / reaction
 ENSGALG00000006418 PDPK1 / 3-phosphoinositide dependent protein kinase 1 / O15530* / Q9Z2A0*  / complex / reaction
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSGALG00000008015 UBE2V1 / ubiquitin-conjugating enzyme E2 variant 1 / Q13404* / ubiquitin conjugating enzyme E2 V1*  / complex
 ENSGALG00000016284 TAB3 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3 / Q571K4* / Q8N5C8* / TGF-beta activated kinase 1/MAP3K7 binding protein 3*  / complex / reaction
 ENSGALG00000008407 IRAK2 / interleukin-1 receptor-associated kinase-like 2 / O43187* / Q8CFA1* / interleukin 1 receptor associated kinase 2*  / reaction / complex
 ENSGALG00000012356 TAB2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q99K90* / Q9NYJ8* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / reaction / complex
 ENSGALG00000013057 USP41* / USP18* / Q9WTV6* / Q3LFD5* / Q9UMW8* / ubiquitin specific peptidase 18* / ubiquitin specific peptidase 41*  / complex
 ENSGALG00000004370 MAP2K6 / mitogen-activated protein kinase kinase 6 / P52564* / P70236*  / reaction
 ENSGALG00000036807 NOD1 / Gallus gallus nucleotide binding oligomerization domain containing 1 (NOD1), mRNA. / Q8BHB0* / Q9Y239* / nucleotide binding oligomerization domain containing 1* / Nucleotide-binding ...  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000026850 TICAM1 / TIR domain-containing adapter molecule 1 / Q80UF7* / Q8IUC6* / toll like receptor adaptor molecule 1*  / reaction / complex
 ENSGALG00000030063 MALT1 / MALT1 paracaspase / Q2TBA3* / Q9UDY8* / Mucosa-associated lymphoid tissue lymphoma translocation *  / reaction / complex
 ENSGALG00000032178 MAP2K4 / mitogen-activated protein kinase kinase 4 / P45985* / P47809* / Dual specificity mitogen-activated protein kinase kinase 4 *  / reaction
 ENSGALG00000034970 PRKCQ / protein kinase C theta / Q02111* / Q04759*  / reaction / complex
 ENSGALG00000043535 RIPK2 / receptor-interacting serine/threonine-protein kinase 2 / O43353* / P58801* / receptor interacting serine/threonine kinase 2* / receptor (TNFRSF)-interacting serine-threonine kinase 2*  / complex / reaction
 ENSGALG00000041285 MAP2K3 / mitogen-activated protein kinase kinase 3 / O09110* / P46734*  / reaction
 ENSGALG00000012150 TAB1 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1 / Q15750* / Q8CF89* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 *  / complex / reaction
 ENSGALG00000032701 LY96 / lymphocyte antigen 96 / Q9JHF9* / Q9Y6Y9*  / complex / reaction
 ENSGALG00000015596 MAP3K7 / mitogen-activated protein kinase kinase kinase 7 / O43318* / Q62073*  / complex / reaction
 ENSGALG00000028935 BCL10 / B cell CLL/lymphoma 10 / O95999* / Q9Z0H7* / B-cell lymphoma/leukemia 10 *  / reaction / complex
 ENSGALG00000039140 CD14 / monocyte differentiation antigen CD14 precursor / P10810* / P08571* / CD14 molecule* / Monocyte differentiation antigen CD14 *  / reaction / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex






 

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