ENSMUSG00000028284


Mus musculus

Features
Gene ID: ENSMUSG00000028284
  
Biological name :Map3k7
  
Synonyms : Map3k7 / Mitogen-activated protein kinase kinase kinase 7 / Q62073
  
Possible biological names infered from orthology : O43318
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A5
Gene start: 31964097
Gene end: 32023467
  
Corresponding Affymetrix probe sets: 10503680 (MoGene1.0st)   1419988_at (Mouse Genome 430 2.0 Array)   1425795_a_at (Mouse Genome 430 2.0 Array)   1426627_at (Mouse Genome 430 2.0 Array)   1447801_x_at (Mouse Genome 430 2.0 Array)   1449693_at (Mouse Genome 430 2.0 Array)   1455441_at (Mouse Genome 430 2.0 Array)   1458787_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103819
Ensembl peptide - ENSMUSP00000040307
Ensembl peptide - ENSMUSP00000079734
Ensembl peptide - ENSMUSP00000103818
NCBI entrez gene - 26409     See in Manteia.
MGI - MGI:1346877
RefSeq - XM_006537948
RefSeq - NM_009316
RefSeq - NM_172688
RefSeq Peptide - NP_033342
RefSeq Peptide - NP_766276
swissprot - Q62073
swissprot - A2AP93
swissprot - Q923A8
swissprot - Q543B5
swissprot - A2AP92
Ensembl - ENSMUSG00000028284
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k7ENSDARG00000020469Danio rerio
 MAP3K7ENSGALG00000015596Gallus gallus
 MAP3K7ENSG00000135341Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q66L42 / Map3k10 / Mitogen-activated protein kinase kinase kinase 10 / Q02779*ENSMUSG0000004039027
Map3k9 / Q3U1V8 / Mitogen-activated protein kinase kinase kinase 9 / P80192*ENSMUSG0000004272427
Q8VDG6 / Map3k21 / Mitogen-activated protein kinase kinase kinase 21 / Q5TCX8*ENSMUSG0000003185325
Q80XI6 / Map3k11 / Mitogen-activated protein kinase kinase kinase 11 / Q16584*ENSMUSG0000000405424
Q9ESL4 / Map3k20 / Mitogen-activated protein kinase kinase kinase 20 / Q9NYL2*ENSMUSG0000000408521
Q1HKZ5 / Map3k13 / Mitogen-activated protein kinase kinase kinase 13 / O43283*ENSMUSG0000003361820
Q60700 / Map3k12 / Mus musculus mitogen-activated protein kinase kinase kinase 12 (Map3k12), transcript variant 3, mRNA. / Q12852* / mitogen-activated protein kinase kinase kinase 12*ENSMUSG0000002305019
Q5GIG6 / Tnni3k / TNNI3 interacting kinase / Q59H18* / FPGT-TNNI3K* / FPGT-TNNI3K readthrough*ENSMUSG0000004008618
Mos / MOS proto-oncogene, serine/threonine kinase / P00540*ENSMUSG0000007836513
Ilk / O55222 / Integrin-linked protein kinase / Q13418* / integrin linked kinase*ENSMUSG0000003089011


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017421  Mitogen-activated protein (MAP) kinase kinase kinase 7
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001841 neural tube formation IMP
 biological_processGO:0002726 positive regulation of T cell cytokine production IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IEA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0016239 positive regulation of macroautophagy IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032743 positive regulation of interleukin-2 production IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
 biological_processGO:0043276 anoikis IMP
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0043966 histone H3 acetylation IEA
 biological_processGO:0046330 positive regulation of JNK cascade IGI
 biological_processGO:0051403 stress-activated MAPK cascade IEA
 biological_processGO:0060546 negative regulation of necroptotic process IMP
 biological_processGO:1902443 negative regulation of ripoptosome assembly involved in necroptotic process IGI
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008385 IkappaB kinase complex IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004708 MAP kinase kinase activity IDA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097110 scaffold protein binding ISO


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
Ca2+ pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Map3k7tm1Mis/Map3k7tm1Mis,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Map3k7tm1Mis/Map3k7tm1Mis,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Lystbg-8J/Lystbg-8J
Genetic Background: involves: DBA/2J

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Map3k7tm1.1Mds/Map3k7tm1.1Mds
Genetic Background: Not Specified

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001665 chronic diarrhea "prolonged diarrhea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Map3k7tm1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Map3k7tm1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002672 abnormal branchial arch artery morphology "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Map3k7tm1.1Mds/Map3k7tm1.1Mds
Genetic Background: Not Specified

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0003255 bile duct proliferation "the appearance of an increased number of bile ducts in the liver; a sign of progressive liver disease" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003829 impaired febrile response "reduced or absent febrile response to exogenous or endogenous pyrogens" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:70534]
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Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004972 abnormal regulatory T cell number "deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004975 absent regulatory T cells "absence of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Map3k7tm1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Map3k7tm1Zjc/Map3k7tm1Zjc,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Map3k7tm1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Casp8tm1Clie/Casp8tm1Clie,Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005415 intrahepatic cholestasis "impariment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Map3k7tm1Zjc/Map3k7tm1Zjc,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Map3k7tm1Zjc/Map3k7tm1Zjc,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008350 increased gamma-delta intraepithelial T cell number "greater number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008399 abnormal alpha-beta intraepithelial T cell morphology "any structural anomaly of a alpha-beta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Map3k7tm1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Map3k7tm1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k7tm1Mis/Map3k7tm1Mis,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008594 decreased circulating interleukin-10 level "reduction in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008895 abnormal intraepithelial T cell number "reduced number of T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k7tm1Zjc/Map3k7tm1Zjc,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0009655 abnormal secondary palate development "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
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Allelic Composition: Map3k7tm1Mis/Map3k7tm1Mis,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k7tm1.1Gkl/Map3k7tm1.1Gkl,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009883 palatal shelf hypoplasia "reduced size of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate, often due to reduced cell number" [PMID:16680722]
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Allelic Composition: Map3k7tm1Mis/Map3k7tm1Mis,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Map3k7tm1Mis/Map3k7tm1Mis,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Map3k7tm1Mis/Map3k7tm1Mis,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011009 increased circulating glutamate dehydrogenase level "increased concentration in the blood of the enzymes which catalyze the reaction of L-glutamate, water and NAD+, producing alpha-ketoglutarate, ammonia, and NADH" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Map3k7tm1Mis/Map3k7tm1Mis,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gtpbp2nmf205/Gtpbp2nmf205,n-TRtct5m1J/n-TRtct5+
Genetic Background: involves: C57BL/6J * NOD/ShiLtJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Map3k7Gt(XB444)Byg/Map3k7Gt(XB444)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Map3k7tm1Mds/Map3k7tm1Mds,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: FVB/N

Allelic Composition: Map3k7tm1.1Mds/Map3k7tm1.1Mds
Genetic Background: Not Specified

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0011705 absent fibroblast proliferation "failure of a fibroblast cell population to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Lcn2tm1Mak/Lcn2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0014201 abnormal intestinal epithelium physiology "any functional anomaly of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [ISBN:0-683-40008-8, MGI:Anna]
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Allelic Composition: Map3k7tm1Aki/Map3k7tm1Aki,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction / complex
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / complex / reaction
 ENSMUSG00000041135 Ripk2 / P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / O43353* / receptor interacting serine/threonine kinase 2*  / reaction / complex
 ENSMUSG00000026928 Card9 / A2AIV8 / Caspase recruitment domain-containing protein 9 / Q9H257* / caspase recruitment domain family member 9*  / complex / reaction
 ENSMUSG00000038058 Nod1 / Q8BHB0 / Nucleotide-binding oligomerization domain-containing protein 1 / Q9Y239* / nucleotide binding oligomerization domain containing 1*  / complex / reaction
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / reaction / complex
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction / complex
 ENSMUSG00000055994 Nod2 / Q8K3Z0 / Nucleotide-binding oligomerization domain-containing protein 2 / Q9HC29* / nucleotide binding oligomerization domain containing 2*  / complex / reaction
 ENSMUSG00000002948 Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*  / reaction
 ENSMUSG00000026778 Prkcq / Q02111 / protein kinase C, theta / Q04759*  / complex / reaction
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / complex / reaction
 ENSMUSG00000033352 Map2k4 / P47809 / Dual specificity mitogen-activated protein kinase kinase 4 / P45985* / mitogen-activated protein kinase kinase 4*  / reaction
 ENSMUSG00000032688 Malt1 / Q2TBA3 / Mucosa-associated lymphoid tissue lymphoma translocation / Q9UDY8* / MALT1 paracaspase*  / complex / reaction
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / reaction / complex
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / reaction
 ENSMUSG00000020623 Map2k6 / P70236 / mitogen-activated protein kinase kinase 6 / P52564*  / reaction
 ENSMUSG00000018932 Map2k3 / O09110 / mitogen-activated protein kinase kinase 3 / P46734*  / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / complex / reaction
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / complex / reaction
 ENSMUSG00000060477 Irak2 / Q8CFA1 / Interleukin-1 receptor-associated kinase-like 2 / O43187* / interleukin 1 receptor associated kinase 2*  / reaction / complex
 ENSMUSG00000028191 Bcl10 / Q9Z0H7 / B-cell lymphoma/leukemia 10 / O95999* / B cell CLL/lymphoma 10*  / complex / reaction
 ENSMUSG00000036526 Card11 / Q8CIS0 / Caspase recruitment domain-containing protein 11 / Q9BXL7* / caspase recruitment domain family member 11*  / reaction / complex
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex / reaction
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / complex / reaction
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / complex / reaction
 ENSMUSG00000030107 Usp18 / Q9WTV6 / ubiquitin specific peptidase 18 / USP41* / Q9UMW8* / Q3LFD5* / ubiquitin specific peptidase 41*  / complex
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / complex / reaction
 ENSMUSG00000035476 Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction






 

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