ENSMUSG00000004054


Mus musculus

Features
Gene ID: ENSMUSG00000004054
  
Biological name :Map3k11
  
Synonyms : Map3k11 / Mitogen-activated protein kinase kinase kinase 11 / Q80XI6
  
Possible biological names infered from orthology : Q16584
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 5689131
Gene end: 5702862
  
Corresponding Affymetrix probe sets: 10460645 (MoGene1.0st)   1450669_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004156
NCBI entrez gene - 26403     See in Manteia.
MGI - MGI:1346880
RefSeq - XM_006531753
RefSeq - NM_022012
RefSeq - XM_006531752
RefSeq Peptide - NP_071295
swissprot - Q80XI6
Ensembl - ENSMUSG00000004054
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP3K11ENSDARG00000091521Danio rerio
 Q16584ENSG00000173327Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map3k9 / Q3U1V8 / Mitogen-activated protein kinase kinase kinase 9 / P80192*ENSMUSG0000004272450
Q66L42 / Map3k10 / Mitogen-activated protein kinase kinase kinase 10 / Q02779*ENSMUSG0000004039049
Q8VDG6 / Map3k21 / Mitogen-activated protein kinase kinase kinase 21 / Q5TCX8*ENSMUSG0000003185347
Q60700 / Map3k12 / Mus musculus mitogen-activated protein kinase kinase kinase 12 (Map3k12), transcript variant 3, mRNA. / Q12852* / mitogen-activated protein kinase kinase kinase 12*ENSMUSG0000002305024
Q1HKZ5 / Map3k13 / Mitogen-activated protein kinase kinase kinase 13 / O43283*ENSMUSG0000003361824
Q9ESL4 / Map3k20 / Mitogen-activated protein kinase kinase kinase 20 / Q9NYL2*ENSMUSG0000000408520
Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*ENSMUSG0000002828417
Q5GIG6 / Tnni3k / TNNI3 interacting kinase / Q59H18* / FPGT-TNNI3K* / FPGT-TNNI3K readthrough*ENSMUSG0000004008615
Ilk / O55222 / Integrin-linked protein kinase / Q13418* / integrin linked kinase*ENSMUSG0000003089010
Mos / MOS proto-oncogene, serine/threonine kinase / P00540*ENSMUSG000000783659


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016231  Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4
 IPR017441  Protein kinase, ATP binding site
 IPR035779  MLK1-3, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0007017 microtubule-based process IEA
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0007256 activation of JNKK activity IEA
 biological_processGO:0007257 activation of JUN kinase activity IEA
 biological_processGO:0008219 cell death IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004706 JUN kinase kinase kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IEA
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
RAF activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Safbtm1So/Safb+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002819 abnormal pulp cavity morphology "defects in the central hollow space of a tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C4btm1Crr/C4btm1Crr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Map3k10tm1Dsd/Map3k10tm1Dsd,Map3k11tm1Rjd/Map3k11tm1Rjd
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: C4btm1Crr/C4btm1Crr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Map3k10tm1Dsd/Map3k10tm1Dsd,Map3k11tm1Rjd/Map3k11tm1Rjd
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: C4btm1Crr/C4btm1Crr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Map3k10tm1Dsd/Map3k10tm1Dsd,Map3k11tm1Rjd/Map3k11tm1Rjd
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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