ENSMUSG00000023050


Mus musculus

Features
Gene ID: ENSMUSG00000023050
  
Biological name :Map3k12
  
Synonyms : Map3k12 / Mus musculus mitogen-activated protein kinase kinase kinase 12 (Map3k12), transcript variant 3, mRNA. / Q60700
  
Possible biological names infered from orthology : mitogen-activated protein kinase kinase kinase 12 / Q12852
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F3
Gene start: 102497646
Gene end: 102517064
  
Corresponding Affymetrix probe sets: 10433008 (MoGene1.0st)   1417115_at (Mouse Genome 430 2.0 Array)   1438908_at (Mouse Genome 430 2.0 Array)   1456565_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129472
Ensembl peptide - ENSMUSP00000129251
Ensembl peptide - ENSMUSP00000130786
Ensembl peptide - ENSMUSP00000133209
Ensembl peptide - ENSMUSP00000023812
Ensembl peptide - ENSMUSP00000127629
NCBI entrez gene - 26404     See in Manteia.
MGI - MGI:1346881
RefSeq - XM_017316626
RefSeq - NM_001163643
RefSeq - NM_001358844
RefSeq - NM_009582
RefSeq - XM_006521013
RefSeq - XM_017316624
RefSeq - XM_017316625
RefSeq Peptide - NP_033608
RefSeq Peptide - NP_001345773
RefSeq Peptide - NP_001157115
swissprot - E9PUZ1
swissprot - Q60700
swissprot - E9QA89
swissprot - E9PZU4
Ensembl - ENSMUSG00000023050
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k12ENSDARG00000103651Danio rerio
 ENSGALG00000031572Gallus gallus
 Q12852ENSG00000139625Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q1HKZ5 / Map3k13 / Mitogen-activated protein kinase kinase kinase 13 / O43283*ENSMUSG0000003361854
Q66L42 / Map3k10 / Mitogen-activated protein kinase kinase kinase 10 / Q02779*ENSMUSG0000004039025
Map3k9 / Q3U1V8 / Mitogen-activated protein kinase kinase kinase 9 / P80192*ENSMUSG0000004272425
Q8VDG6 / Map3k21 / Mitogen-activated protein kinase kinase kinase 21 / Q5TCX8*ENSMUSG0000003185323
Q80XI6 / Map3k11 / Mitogen-activated protein kinase kinase kinase 11 / Q16584*ENSMUSG0000000405423
Q9ESL4 / Map3k20 / Mitogen-activated protein kinase kinase kinase 20 / Q9NYL2*ENSMUSG0000000408516
Q5GIG6 / Tnni3k / TNNI3 interacting kinase / Q59H18* / FPGT-TNNI3K* / FPGT-TNNI3K readthrough*ENSMUSG0000004008613
Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*ENSMUSG0000002828413
Ilk / O55222 / Integrin-linked protein kinase / Q13418* / integrin linked kinase*ENSMUSG0000003089010
Mos / MOS proto-oncogene, serine/threonine kinase / P00540*ENSMUSG000000783659


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017419  Mitogen-activated protein kinase kinase kinase 12/13
 IPR027257  Mitogen-activated protein kinase kinase kinase 12


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IBA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016572 histone phosphorylation IDA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:2000672 negative regulation of motor neuron apoptotic process IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030426 growth cone IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Map3k12Gt(RRN366)Byg/Map3k12Gt(RRN366)Byg,Mycbp2tm1.1Adia/Mycbp2tm1.1Adia
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Map3k12tm1.1Adia/Map3k12tm1.1Adia
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Map3k12Gt(RRN366)Byg/Map3k12Gt(RRN366)Byg,Mycbp2tm1.1Adia/Mycbp2tm1.1Adia
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005192 increased motor neuron number "greater than the normal number of cells that innervate an effector (muscle or glandular) tissue" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0005237 abnormal olfactory tract morphology "structural anomaly of the nervelike, white band composed primarily of nerve fibers originating from the mitral cells and tufted cells of the olfactory bulb, but also containing the scattered cells of the anterior olfactory nucleus " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34460]
Show

Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ilktm2Star/Ilk+,Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Map3k12Gt(RRN366)Byg/Map3k12Gt(RRN366)Byg,Mycbp2tm1.1Adia/Mycbp2tm1.1Adia
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008129 absent brain internal capsule "absence of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map3k12Gt(RRN366)Byg/Map3k12Gt(RRN366)Byg,Mycbp2tm1.1Adia/Mycbp2tm1.1Adia
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0008227 absent anterior commissure "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Mycbp2tm1Adia/Mycbp2tm1Adia
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008232 abnormal cingulum morphology "any structural anomaly of the white matter fiber bundle that projects from the cingulate gyrus to the entorhinal cortex in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0010654 slow Wallerian degeneration "an increase in the length of time for the process of progressive degeneration of axons distal to an injury to occur" [PMID:20345246]
Show

Allelic Composition: Setdb1tm1.1Yshk/Setdb1tm1.1Yshk,Tg(Nes-cre)1Kag/0
Genetic Background: Not Specified

Allelic Composition: Map3k12tm1.1Adia/Map3k12tm1.1Adia
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

Allelic Composition: Map3k12tm1.2Adia/Map3k12tm1.2Adia
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0010859 abnormal anterior commissure pars anterior morphology "any structural anomaly of the small horseshoe-shaped anterior part of the anterior commissure which pass into the two olfactory bulbs" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0010860 abnormal anterior commissure pars posterior morphology "any structural anomaly of the large posterior part of the anterior commissure which connects the right and left temporal lobes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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