ENSMUSG00000004085


Mus musculus

Features
Gene ID: ENSMUSG00000004085
  
Biological name :Map3k20
  
Synonyms : Map3k20 / Mitogen-activated protein kinase kinase kinase 20 / Q9ESL4
  
Possible biological names infered from orthology : Q9NYL2
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C3
Gene start: 72285637
Gene end: 72442610
  
Corresponding Affymetrix probe sets: 10472893 (MoGene1.0st)   1418943_at (Mouse Genome 430 2.0 Array)   1425847_a_at (Mouse Genome 430 2.0 Array)   1435029_at (Mouse Genome 430 2.0 Array)   1441897_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000088334
Ensembl peptide - ENSMUSP00000118983
Ensembl peptide - ENSMUSP00000119340
NCBI entrez gene - 65964     See in Manteia.
MGI - MGI:2443258
RefSeq - XM_006499997
RefSeq - NM_001164791
RefSeq - NM_023057
RefSeq - NM_178084
RefSeq Peptide - NP_001158263
RefSeq Peptide - NP_075544
RefSeq Peptide - NP_835185
swissprot - Q3TRG2
swissprot - Q9ESL4
swissprot - A2ASW6
Ensembl - ENSMUSG00000004085
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zakENSDARG00000006978Danio rerio
 zakENSDARG00000044615Danio rerio
 MAP3K20ENSGALG00000035237Gallus gallus
 Q9NYL2ENSG00000091436Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map3k9 / Q3U1V8 / Mitogen-activated protein kinase kinase kinase 9 / P80192*ENSMUSG0000004272426
Q66L42 / Map3k10 / Mitogen-activated protein kinase kinase kinase 10 / Q02779*ENSMUSG0000004039025
Q8VDG6 / Map3k21 / Mitogen-activated protein kinase kinase kinase 21 / Q5TCX8*ENSMUSG0000003185324
Q80XI6 / Map3k11 / Mitogen-activated protein kinase kinase kinase 11 / Q16584*ENSMUSG0000000405421
Q1HKZ5 / Map3k13 / Mitogen-activated protein kinase kinase kinase 13 / O43283*ENSMUSG0000003361819
Q60700 / Map3k12 / Mus musculus mitogen-activated protein kinase kinase kinase 12 (Map3k12), transcript variant 3, mRNA. / Q12852* / mitogen-activated protein kinase kinase kinase 12*ENSMUSG0000002305018
Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*ENSMUSG0000002828416
Q5GIG6 / Tnni3k / TNNI3 interacting kinase / Q59H18* / FPGT-TNNI3K* / FPGT-TNNI3K readthrough*ENSMUSG0000004008613
Mos / MOS proto-oncogene, serine/threonine kinase / P00540*ENSMUSG000000783659
Ilk / O55222 / Integrin-linked protein kinase / Q13418* / integrin linked kinase*ENSMUSG000000308909


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001660  Sterile alpha motif domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR032938  Mitogen-activated protein kinase kinase kinase MLT


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint ISO
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007010 cytoskeleton organization IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest ISO
 biological_processGO:0007093 mitotic cell cycle checkpoint ISS
 biological_processGO:0007257 activation of JUN kinase activity IBA
 biological_processGO:0009314 response to radiation ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042733 embryonic digit morphogenesis ISO
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0051403 stress-activated MAPK cascade IEA
 biological_processGO:0060173 limb development ISO
 biological_processGO:0071480 cellular response to gamma radiation IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Oprk1tm1.2Waca/Oprk1tm1.2Waca
Genetic Background: B6J.B6NTac(Cg)-Oprk1tm1.2Waca

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Oprk1tm1.2Waca/Oprk1tm1.2Waca
Genetic Background: B6J.B6NTac(Cg)-Oprk1tm1.2Waca

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oprk1tm1.2Waca/Oprk1tm1.2Waca
Genetic Background: B6J.B6NTac(Cg)-Oprk1tm1.2Waca

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oprk1tm1.2Waca/Oprk1tm1.2Waca
Genetic Background: B6J.B6NTac(Cg)-Oprk1tm1.2Waca

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Oprk1tm1.2Waca/Oprk1tm1.2Waca
Genetic Background: B6J.B6NTac(Cg)-Oprk1tm1.2Waca

 MP:0012270 cardiac edema "abnormal accumulation of fluid in the interstitial tissues and cavities of the body due to impaired cardiac function or congestive heart failure; usually characterized by increased venous and capillary pressures and often associated with renal sodium retention" [MGI:anna]
Show

Allelic Composition: Oprk1tm1.2Waca/Oprk1tm1.2Waca
Genetic Background: B6J.B6NTac(Cg)-Oprk1tm1.2Waca

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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