ENSMUSG00000040086


Mus musculus

Features
Gene ID: ENSMUSG00000040086
  
Biological name :Tnni3k
  
Synonyms : Q5GIG6 / TNNI3 interacting kinase / Tnni3k
  
Possible biological names infered from orthology : FPGT-TNNI3K / FPGT-TNNI3K readthrough / Q59H18
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H4
Gene start: 154786291
Gene end: 155055407
  
Corresponding Affymetrix probe sets: 10502982 (MoGene1.0st)   1446479_at (Mouse Genome 430 2.0 Array)   1458482_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070561
Ensembl peptide - ENSMUSP00000122478
NCBI entrez gene - 435766     See in Manteia.
MGI - MGI:2443276
RefSeq - XM_011240155
RefSeq - NM_177066
RefSeq - XM_011240154
RefSeq Peptide - NP_796040
swissprot - Q5GIG6
Ensembl - ENSMUSG00000040086
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnni3kENSDARG00000086933Danio rerio
 TNNI3KENSGALG00000011353Gallus gallus
 FPGT-TNNI3KENSG00000259030Homo sapiens
 Q59H18ENSG00000116783Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map3k9 / Q3U1V8 / Mitogen-activated protein kinase kinase kinase 9 / P80192*ENSMUSG0000004272418
Q66L42 / Map3k10 / Mitogen-activated protein kinase kinase kinase 10 / Q02779*ENSMUSG0000004039017
Q8VDG6 / Map3k21 / Mitogen-activated protein kinase kinase kinase 21 / Q5TCX8*ENSMUSG0000003185316
Q80XI6 / Map3k11 / Mitogen-activated protein kinase kinase kinase 11 / Q16584*ENSMUSG0000000405416
Q1HKZ5 / Map3k13 / Mitogen-activated protein kinase kinase kinase 13 / O43283*ENSMUSG0000003361815
Q60700 / Map3k12 / Mus musculus mitogen-activated protein kinase kinase kinase 12 (Map3k12), transcript variant 3, mRNA. / Q12852* / mitogen-activated protein kinase kinase kinase 12*ENSMUSG0000002305014
Ilk / O55222 / Integrin-linked protein kinase / Q13418* / integrin linked kinase*ENSMUSG0000003089014
Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*ENSMUSG0000002828413
Q9ESL4 / Map3k20 / Mitogen-activated protein kinase kinase kinase 20 / Q9NYL2*ENSMUSG0000000408513
Mos / MOS proto-oncogene, serine/threonine kinase / P00540*ENSMUSG000000783659


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002110  Ankyrin repeat
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate ISO
 biological_processGO:0006468 protein phosphorylation IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0055117 regulation of cardiac muscle contraction ISO
 biological_processGO:0086069 bundle of His cell to Purkinje myocyte communication ISO
 biological_processGO:1903779 regulation of cardiac conduction ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IBA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031013 troponin I binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atf6tm1Hota/Atf6tm1Hota,Tg(Ins2-cre)25Mgn/0,Tg(Ins2-GP)1Kbuw/0
Genetic Background: involves: C57BL/6 * DBA

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lancl1em1Vdd/Lancl1em1Vdd,Lancl2em1Vdd/Lancl2em1Vdd,Lancl3em1Vdd/Lancl3em1Vdd
Genetic Background: FVB/N-Lancl1em1Vdd Lancl2em1Vdd Lancl3em1Vdd

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Tnni3ktm1Tfo/Tnni3ktm1Tfo,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnni3ktm1Tfo/Tnni3ktm1Tfo,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Tnni3ktm1.1Tfo/Tnni3ktm1.1Tfo
Genetic Background: involves: C57BL/6

 MP:0006321 increased myocardial fiber number "increased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnni3ktm1.1Tfo/Tnni3ktm1.1Tfo
Genetic Background: involves: C57BL/6

Allelic Composition: A1cfTg(Myh6-cre/Esr1*)1Jmk/?,Tnni3ktm1Tfo/Tnni3ktm1Tfo
Genetic Background: involves: C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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