ENSMUSG00000040390


Mus musculus

Features
Gene ID: ENSMUSG00000040390
  
Biological name :Map3k10
  
Synonyms : Map3k10 / Mitogen-activated protein kinase kinase kinase 10 / Q66L42
  
Possible biological names infered from orthology : Q02779
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 27656375
Gene end: 27674598
  
Corresponding Affymetrix probe sets: 10561323 (MoGene1.0st)   1436373_at (Mouse Genome 430 2.0 Array)   1440500_at (Mouse Genome 430 2.0 Array)   1457456_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146275
Ensembl peptide - ENSMUSP00000037725
Ensembl peptide - ENSMUSP00000103978
NCBI entrez gene - 269881     See in Manteia.
MGI - MGI:1346879
RefSeq - XM_017322291
RefSeq - XM_017322287
RefSeq - XM_017322288
RefSeq - XM_017322289
RefSeq - XM_017322290
RefSeq - NM_001290528
RefSeq Peptide - NP_001277457
swissprot - D3YXM8
swissprot - A0A0U1RQ74
swissprot - Q66L42
Ensembl - ENSMUSG00000040390
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k10ENSDARG00000055672Danio rerio
 Q02779ENSG00000130758Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map3k9 / Q3U1V8 / Mitogen-activated protein kinase kinase kinase 9 / P80192*ENSMUSG0000004272460
Q8VDG6 / Map3k21 / Mitogen-activated protein kinase kinase kinase 21 / Q5TCX8*ENSMUSG0000003185346
Q80XI6 / Map3k11 / Mitogen-activated protein kinase kinase kinase 11 / Q16584*ENSMUSG0000000405444
Q1HKZ5 / Map3k13 / Mitogen-activated protein kinase kinase kinase 13 / O43283*ENSMUSG0000003361824
Q60700 / Map3k12 / Mus musculus mitogen-activated protein kinase kinase kinase 12 (Map3k12), transcript variant 3, mRNA. / Q12852* / mitogen-activated protein kinase kinase kinase 12*ENSMUSG0000002305023
Q9ESL4 / Map3k20 / Mitogen-activated protein kinase kinase kinase 20 / Q9NYL2*ENSMUSG0000000408522
Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*ENSMUSG0000002828417
Q5GIG6 / Tnni3k / TNNI3 interacting kinase / Q59H18* / FPGT-TNNI3K* / FPGT-TNNI3K readthrough*ENSMUSG0000004008615
Ilk / O55222 / Integrin-linked protein kinase / Q13418* / integrin linked kinase*ENSMUSG0000003089010
Mos / MOS proto-oncogene, serine/threonine kinase / P00540*ENSMUSG000000783659


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015785  Mitogen-activated protein (MAP) kinase kinase kinase 10
 IPR016231  Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4
 IPR017441  Protein kinase, ATP binding site
 IPR035779  MLK1-3, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007256 activation of JNKK activity IEA
 biological_processGO:0007257 activation of JUN kinase activity IBA
 biological_processGO:0008219 cell death IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004706 JUN kinase kinase kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043425 bHLH transcription factor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sharpincpdm/Sharpincpdm
Genetic Background: involves: C57BL/KaLawRij * FVB/NJ

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0004646 decreased cervical vertebrae number "reduced number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: C4btm1Crr/C4btm1Crr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Map3k10tm1Dsd/Map3k10tm1Dsd,Map3k11tm1Rjd/Map3k11tm1Rjd
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: C4btm1Crr/C4btm1Crr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Map3k10tm1Dsd/Map3k10tm1Dsd,Map3k11tm1Rjd/Map3k11tm1Rjd
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: C4btm1Crr/C4btm1Crr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Map3k10tm1Dsd/Map3k10tm1Dsd,Map3k11tm1Rjd/Map3k11tm1Rjd
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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