ENSG00000130758


Homo sapiens

Features
Gene ID: ENSG00000130758
  
Biological name :MAP3K10
  
Synonyms : MAP3K10 / mitogen-activated protein kinase kinase kinase 10 / Q02779
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.2
Gene start: 40191744
Gene end: 40215575
  
Corresponding Affymetrix probe sets: 206362_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000253055
Ensembl peptide - ENSP00000471116
Ensembl peptide - ENSP00000471916
Ensembl peptide - ENSP00000473021
NCBI entrez gene - 4294     See in Manteia.
OMIM - 600137
RefSeq - XM_011526982
RefSeq - NM_002446
RefSeq - XM_006723222
RefSeq - XM_011526981
RefSeq Peptide - NP_002437
swissprot - Q02779
swissprot - M0R1J8
swissprot - M0R365
swissprot - M0R0A7
Ensembl - ENSG00000130758
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k10ENSDARG00000055672Danio rerio
 Q66L42ENSMUSG00000040390Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP3K9 / P80192 / mitogen-activated protein kinase kinase kinase 9ENSG0000000643259
Q5TCX8 / MAP3K21 / mitogen-activated protein kinase kinase kinase 21ENSG0000014367448
Q16584 / MAP3K11 / mitogen-activated protein kinase kinase kinase 11ENSG0000017332743
Q12852 / MAP3K12 / mitogen-activated protein kinase kinase kinase 12ENSG0000013962524
O43283 / MAP3K13 / mitogen-activated protein kinase kinase kinase 13ENSG0000007380324
Q9NYL2 / MAP3K20 / mitogen-activated protein kinase kinase kinase 20ENSG0000009143621
MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7ENSG0000013534117
Q59H18 / TNNI3K / TNNI3 interacting kinaseENSG0000011678315
FPGT-TNNI3K / FPGT-TNNI3K readthroughENSG0000025903015
ILK / Q13418 / integrin linked kinaseENSG0000016633310
MOS / P00540 / MOS proto-oncogene, serine/threonine kinaseENSG000001726809


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015785  Mitogen-activated protein (MAP) kinase kinase kinase 10
 IPR016231  Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4
 IPR017441  Protein kinase, ATP binding site
 IPR035779  MLK1-3, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0007254 JNK cascade TAS
 biological_processGO:0007256 activation of JNKK activity IEA
 biological_processGO:0007257 activation of JUN kinase activity ISS
 biological_processGO:0008219 cell death IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0043507 positive regulation of JUN kinase activity IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0046330 positive regulation of JNK cascade IMP
 biological_processGO:0046777 protein autophosphorylation ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004706 JUN kinase kinase kinase activity IBA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043425 bHLH transcription factor binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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