ENSG00000073803


Homo sapiens

Features
Gene ID: ENSG00000073803
  
Biological name :MAP3K13
  
Synonyms : MAP3K13 / mitogen-activated protein kinase kinase kinase 13 / O43283
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q27.2
Gene start: 185282941
Gene end: 185489097
  
Corresponding Affymetrix probe sets: 1562440_at (Human Genome U133 Plus 2.0 Array)   206249_at (Human Genome U133 Plus 2.0 Array)   211083_s_at (Human Genome U133 Plus 2.0 Array)   226190_at (Human Genome U133 Plus 2.0 Array)   226556_at (Human Genome U133 Plus 2.0 Array)   229771_at (Human Genome U133 Plus 2.0 Array)   233508_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000407361
Ensembl peptide - ENSP00000409325
Ensembl peptide - ENSP00000415712
Ensembl peptide - ENSP00000412037
Ensembl peptide - ENSP00000411483
Ensembl peptide - ENSP00000265026
Ensembl peptide - ENSP00000389495
Ensembl peptide - ENSP00000389798
Ensembl peptide - ENSP00000390323
Ensembl peptide - ENSP00000392223
Ensembl peptide - ENSP00000399910
Ensembl peptide - ENSP00000403561
Ensembl peptide - ENSP00000405163
Ensembl peptide - ENSP00000405233
NCBI entrez gene - 9175     See in Manteia.
OMIM - 604915
RefSeq - XM_011513310
RefSeq - XM_017007459
RefSeq - XM_017007458
RefSeq - XM_017007457
RefSeq - XM_017007456
RefSeq - NM_001242314
RefSeq - NM_001242317
RefSeq - NM_004721
RefSeq Peptide - NP_001229243
RefSeq Peptide - NP_001229246
RefSeq Peptide - NP_004712
swissprot - O43283
swissprot - C9JP65
swissprot - H7C459
swissprot - F8WF41
swissprot - C9IYH2
swissprot - C9J4W2
Ensembl - ENSG00000073803
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP3K13ENSDARG00000009493Danio rerio
 MAP3K13ENSGALG00000006655Gallus gallus
 Q1HKZ5ENSMUSG00000033618Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q12852 / MAP3K12 / mitogen-activated protein kinase kinase kinase 12ENSG0000013962551
MAP3K9 / P80192 / mitogen-activated protein kinase kinase kinase 9ENSG0000000643225
Q02779 / MAP3K10 / mitogen-activated protein kinase kinase kinase 10ENSG0000013075824
Q5TCX8 / MAP3K21 / mitogen-activated protein kinase kinase kinase 21ENSG0000014367423
Q16584 / MAP3K11 / mitogen-activated protein kinase kinase kinase 11ENSG0000017332722
Q9NYL2 / MAP3K20 / mitogen-activated protein kinase kinase kinase 20ENSG0000009143616
Q59H18 / TNNI3K / TNNI3 interacting kinaseENSG0000011678314
FPGT-TNNI3K / FPGT-TNNI3K readthroughENSG0000025903014
MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7ENSG0000013534113
ILK / Q13418 / integrin linked kinaseENSG000001663339
MOS / P00540 / MOS proto-oncogene, serine/threonine kinaseENSG000001726809


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017419  Mitogen-activated protein kinase kinase kinase 12/13
 IPR027258  Mitogen-activated protein kinase kinase kinase 13


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007254 JNK cascade IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0008385 IkappaB kinase complex IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding ISS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr