ENSG00000173327


Homo sapiens

Features
Gene ID: ENSG00000173327
  
Biological name :MAP3K11
  
Synonyms : MAP3K11 / mitogen-activated protein kinase kinase kinase 11 / Q16584
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.1
Gene start: 65597755
Gene end: 65615382
  
Corresponding Affymetrix probe sets: 1558984_at (Human Genome U133 Plus 2.0 Array)   203652_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000309597
Ensembl peptide - ENSP00000435970
Ensembl peptide - ENSP00000435237
Ensembl peptide - ENSP00000433886
Ensembl peptide - ENSP00000432068
Ensembl peptide - ENSP00000431506
NCBI entrez gene - 4296     See in Manteia.
OMIM - 600050
RefSeq - NM_002419
RefSeq Peptide - NP_002410
swissprot - A0A024R5E6
swissprot - H0YCF5
swissprot - E9PRQ2
swissprot - Q16584
swissprot - E9PLB1
swissprot - E9PID4
Ensembl - ENSG00000173327
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP3K11ENSDARG00000091521Danio rerio
 Q80XI6ENSMUSG00000004054Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5TCX8 / MAP3K21 / mitogen-activated protein kinase kinase kinase 21ENSG0000014367450
MAP3K9 / P80192 / mitogen-activated protein kinase kinase kinase 9ENSG0000000643249
Q02779 / MAP3K10 / mitogen-activated protein kinase kinase kinase 10ENSG0000013075849
O43283 / MAP3K13 / mitogen-activated protein kinase kinase kinase 13ENSG0000007380325
Q12852 / MAP3K12 / mitogen-activated protein kinase kinase kinase 12ENSG0000013962524
Q9NYL2 / MAP3K20 / mitogen-activated protein kinase kinase kinase 20ENSG0000009143620
MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7ENSG0000013534118
FPGT-TNNI3K / FPGT-TNNI3K readthroughENSG0000025903016
Q59H18 / TNNI3K / TNNI3 interacting kinaseENSG0000011678316
ILK / Q13418 / integrin linked kinaseENSG0000016633310
MOS / P00540 / MOS proto-oncogene, serine/threonine kinaseENSG000001726809


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016231  Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035779  MLK1-3, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007017 microtubule-based process IMP
 biological_processGO:0007254 JNK cascade TAS
 biological_processGO:0007256 activation of JNKK activity IEA
 biological_processGO:0007257 activation of JUN kinase activity IMP
 biological_processGO:0008219 cell death IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IBA
 biological_processGO:0043507 positive regulation of JUN kinase activity IMP
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0046330 positive regulation of JNK cascade IMP
 biological_processGO:0046777 protein autophosphorylation IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IDA
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004706 JUN kinase kinase kinase activity IBA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IEA
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
RAF activation
Signaling by moderate kinase activity BRAF mutants
Signaling by RAS mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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