ENSG00000166333


Homo sapiens

Features
Gene ID: ENSG00000166333
  
Biological name :ILK
  
Synonyms : ILK / integrin linked kinase / Q13418
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.4
Gene start: 6603708
Gene end: 6610874
  
Corresponding Affymetrix probe sets: 201234_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435323
Ensembl peptide - ENSP00000487498
Ensembl peptide - ENSP00000480597
Ensembl peptide - ENSP00000479932
Ensembl peptide - ENSP00000439606
Ensembl peptide - ENSP00000436062
Ensembl peptide - ENSP00000299421
Ensembl peptide - ENSP00000379975
Ensembl peptide - ENSP00000403487
Ensembl peptide - ENSP00000432617
Ensembl peptide - ENSP00000434492
NCBI entrez gene - 3611     See in Manteia.
OMIM - 602366
RefSeq - XM_017017672
RefSeq - XM_011520065
RefSeq - XM_005252905
RefSeq - NM_001014794
RefSeq - NM_001014795
RefSeq - NM_001278441
RefSeq - NM_001278442
RefSeq - XM_005252904
RefSeq - NM_004517
RefSeq Peptide - NP_001014794
RefSeq Peptide - NP_001014795
RefSeq Peptide - NP_001265370
RefSeq Peptide - NP_001265371
RefSeq Peptide - NP_004508
swissprot - Q13418
swissprot - V9HWF0
swissprot - E9PQ52
swissprot - A0A087WW45
swissprot - A0A087WWY6
swissprot - A0A0A0MTH3
Ensembl - ENSG00000166333
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ilkENSDARG00000056964Danio rerio
 ILKENSGALG00000031642Gallus gallus
 IlkENSMUSG00000030890Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FPGT-TNNI3K / FPGT-TNNI3K readthroughENSG0000025903026
Q59H18 / TNNI3K / TNNI3 interacting kinaseENSG0000011678326
Q02779 / MAP3K10 / mitogen-activated protein kinase kinase kinase 10ENSG0000013075822
MAP3K9 / P80192 / mitogen-activated protein kinase kinase kinase 9ENSG0000000643221
Q5TCX8 / MAP3K21 / mitogen-activated protein kinase kinase kinase 21ENSG0000014367420
O43283 / MAP3K13 / mitogen-activated protein kinase kinase kinase 13ENSG0000007380319
Q12852 / MAP3K12 / mitogen-activated protein kinase kinase kinase 12ENSG0000013962519
Q16584 / MAP3K11 / mitogen-activated protein kinase kinase kinase 11ENSG0000017332719
Q9NYL2 / MAP3K20 / mitogen-activated protein kinase kinase kinase 20ENSG0000009143616
MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7ENSG0000013534115
MOS / P00540 / MOS proto-oncogene, serine/threonine kinaseENSG0000017268012


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002110  Ankyrin repeat
 IPR011009  Protein kinase-like domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR035692  Integrin-linked protein kinase, pseudokinase domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IBA
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007160 cell-matrix adhesion TAS
 biological_processGO:0007229 integrin-mediated signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0008283 cell proliferation NAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009967 positive regulation of signal transduction IMP
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010761 fibroblast migration IEA
 biological_processGO:0014044 Schwann cell development IEA
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0021675 nerve development IEA
 biological_processGO:0022011 myelination in peripheral nervous system IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0032288 myelin assembly IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0034329 cell junction assembly TAS
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IMP
 biological_processGO:0042327 positive regulation of phosphorylation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0050775 positive regulation of dendrite morphogenesis IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0070527 platelet aggregation HMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0097435 supramolecular fiber organization IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IMP
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation IEA
 cellular_componentGO:0001725 stress fiber IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005925 focal adhesion IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043034 costamere IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Cell-extracellular matrix interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / reaction / complex
 ENSG00000072163 LIMS2 / Q7Z4I7 / LIM zinc finger domain containing 2  / complex
 ENSG00000169756 LIMS1 / P48059 / LIM zinc finger domain containing 1  / complex






 

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