ENSG00000006432


Homo sapiens

Features
Gene ID: ENSG00000006432
  
Biological name :MAP3K9
  
Synonyms : MAP3K9 / mitogen-activated protein kinase kinase kinase 9 / P80192
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q24.2
Gene start: 70722526
Gene end: 70809534
  
Corresponding Affymetrix probe sets: 213927_at (Human Genome U133 Plus 2.0 Array)   214969_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451921
Ensembl peptide - ENSP00000451612
Ensembl peptide - ENSP00000480011
Ensembl peptide - ENSP00000370649
Ensembl peptide - ENSP00000451038
Ensembl peptide - ENSP00000451263
NCBI entrez gene - 4293     See in Manteia.
OMIM - 600136
RefSeq - XM_011536794
RefSeq - NM_001284230
RefSeq - NM_001284231
RefSeq - NM_001284232
RefSeq - NM_033141
RefSeq - XM_005267683
RefSeq - XM_011536788
RefSeq - XM_011536792
RefSeq Peptide - NP_001271161
RefSeq Peptide - NP_149132
RefSeq Peptide - NP_001271160
RefSeq Peptide - NP_001271159
swissprot - P80192
swissprot - A0A087WW79
swissprot - G3V347
swissprot - G3V4P9
swissprot - J3KPI6
Ensembl - ENSG00000006432
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k9ENSDARG00000013491Danio rerio
 MAP3K9ENSGALG00000037326Gallus gallus
 Map3k9ENSMUSG00000042724Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q02779 / MAP3K10 / mitogen-activated protein kinase kinase kinase 10ENSG0000013075850
Q5TCX8 / MAP3K21 / mitogen-activated protein kinase kinase kinase 21ENSG0000014367447
Q16584 / MAP3K11 / mitogen-activated protein kinase kinase kinase 11ENSG0000017332737
O43283 / MAP3K13 / mitogen-activated protein kinase kinase kinase 13ENSG0000007380321
Q12852 / MAP3K12 / mitogen-activated protein kinase kinase kinase 12ENSG0000013962520
Q9NYL2 / MAP3K20 / mitogen-activated protein kinase kinase kinase 20ENSG0000009143618
MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7ENSG0000013534115
Q59H18 / TNNI3K / TNNI3 interacting kinaseENSG0000011678313
FPGT-TNNI3K / FPGT-TNNI3K readthroughENSG0000025903013
MOS / P00540 / MOS proto-oncogene, serine/threonine kinaseENSG000001726808
ILK / Q13418 / integrin linked kinaseENSG000001663338


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016231  Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035779  MLK1-3, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007256 activation of JNKK activity IEA
 biological_processGO:0007257 activation of JUN kinase activity ISS
 biological_processGO:0008219 cell death IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0046777 protein autophosphorylation IDA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004706 JUN kinase kinase kinase activity IEA
 molecular_functionGO:0004708 MAP kinase kinase activity NAS
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr