ENSG00000139625


Homo sapiens

Features
Gene ID: ENSG00000139625
  
Biological name :MAP3K12
  
Synonyms : MAP3K12 / mitogen-activated protein kinase kinase kinase 12 / Q12852
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.13
Gene start: 53479669
Gene end: 53500063
  
Corresponding Affymetrix probe sets: 205447_s_at (Human Genome U133 Plus 2.0 Array)   205448_s_at (Human Genome U133 Plus 2.0 Array)   230921_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000267079
Ensembl peptide - ENSP00000448689
Ensembl peptide - ENSP00000449038
Ensembl peptide - ENSP00000454355
Ensembl peptide - ENSP00000447889
NCBI entrez gene - 7786     See in Manteia.
OMIM - 600447
RefSeq - XM_017019956
RefSeq - NM_001193511
RefSeq - NM_006301
RefSeq - XM_005269138
RefSeq - XM_005269140
RefSeq - XM_006719588
RefSeq - XM_011538725
RefSeq Peptide - NP_001180440
RefSeq Peptide - NP_006292
swissprot - F8VUG4
swissprot - H3BMF0
swissprot - Q12852
swissprot - A0A024RAY5
Ensembl - ENSG00000139625
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k12ENSDARG00000103651Danio rerio
 ENSGALG00000031572Gallus gallus
 Q60700ENSMUSG00000023050Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O43283 / MAP3K13 / mitogen-activated protein kinase kinase kinase 13ENSG0000007380355
MAP3K9 / P80192 / mitogen-activated protein kinase kinase kinase 9ENSG0000000643225
Q02779 / MAP3K10 / mitogen-activated protein kinase kinase kinase 10ENSG0000013075825
Q5TCX8 / MAP3K21 / mitogen-activated protein kinase kinase kinase 21ENSG0000014367424
Q16584 / MAP3K11 / mitogen-activated protein kinase kinase kinase 11ENSG0000017332723
Q9NYL2 / MAP3K20 / mitogen-activated protein kinase kinase kinase 20ENSG0000009143616
Q59H18 / TNNI3K / TNNI3 interacting kinaseENSG0000011678313
FPGT-TNNI3K / FPGT-TNNI3K readthroughENSG0000025903013
MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7ENSG0000013534113
ILK / Q13418 / integrin linked kinaseENSG0000016633310
MOS / P00540 / MOS proto-oncogene, serine/threonine kinaseENSG0000017268010


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017419  Mitogen-activated protein kinase kinase kinase 12/13
 IPR027257  Mitogen-activated protein kinase kinase kinase 12


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IBA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007254 JNK cascade TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016572 histone phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:2000672 negative regulation of motor neuron apoptotic process IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030426 growth cone IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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