ENSG00000143674


Homo sapiens

Features
Gene ID: ENSG00000143674
  
Biological name :MAP3K21
  
Synonyms : MAP3K21 / mitogen-activated protein kinase kinase kinase 21 / Q5TCX8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q42.2
Gene start: 233327768
Gene end: 233385148
  
Corresponding Affymetrix probe sets: 228565_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355582
Ensembl peptide - ENSP00000355583
Ensembl peptide - ENSP00000355581
NCBI entrez gene - 84451     See in Manteia.
OMIM - 614793
RefSeq - NM_032435
RefSeq - XM_011544305
RefSeq Peptide - NP_115811
swissprot - A0A1W2PKR9
swissprot - Q5TCX8
swissprot - X6R610
Ensembl - ENSG00000143674
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k21ENSDARG00000079473Danio rerio
 MAP3K21ENSGALG00000011008Gallus gallus
 Q8VDG6ENSMUSG00000031853Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP3K9 / P80192 / mitogen-activated protein kinase kinase kinase 9ENSG0000000643251
Q02779 / MAP3K10 / mitogen-activated protein kinase kinase kinase 10ENSG0000013075845
Q16584 / MAP3K11 / mitogen-activated protein kinase kinase kinase 11ENSG0000017332741
O43283 / MAP3K13 / mitogen-activated protein kinase kinase kinase 13ENSG0000007380321
Q12852 / MAP3K12 / mitogen-activated protein kinase kinase kinase 12ENSG0000013962520
Q9NYL2 / MAP3K20 / mitogen-activated protein kinase kinase kinase 20ENSG0000009143619
MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7ENSG0000013534115
Q59H18 / TNNI3K / TNNI3 interacting kinaseENSG0000011678313
FPGT-TNNI3K / FPGT-TNNI3K readthroughENSG0000025903013
ILK / Q13418 / integrin linked kinaseENSG000001663339
MOS / P00540 / MOS proto-oncogene, serine/threonine kinaseENSG000001726809


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016231  Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4
 IPR017441  Protein kinase, ATP binding site
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007256 activation of JNKK activity IEA
 biological_processGO:0007257 activation of JUN kinase activity ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046777 protein autophosphorylation ISS
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004706 JUN kinase kinase kinase activity IBA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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