ENSG00000150093


Homo sapiens

Features
Gene ID: ENSG00000150093
  
Biological name :ITGB1
  
Synonyms : integrin subunit beta 1 / ITGB1 / P05556
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: p11.22
Gene start: 32900319
Gene end: 33005792
  
Corresponding Affymetrix probe sets: 1553530_a_at (Human Genome U133 Plus 2.0 Array)   1553678_a_at (Human Genome U133 Plus 2.0 Array)   211945_s_at (Human Genome U133 Plus 2.0 Array)   215878_at (Human Genome U133 Plus 2.0 Array)   215879_at (Human Genome U133 Plus 2.0 Array)   216178_x_at (Human Genome U133 Plus 2.0 Array)   216190_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417243
Ensembl peptide - ENSP00000417508
Ensembl peptide - ENSP00000436214
Ensembl peptide - ENSP00000431326
Ensembl peptide - ENSP00000420792
Ensembl peptide - ENSP00000420416
Ensembl peptide - ENSP00000420282
Ensembl peptide - ENSP00000418725
Ensembl peptide - ENSP00000417799
Ensembl peptide - ENSP00000417537
Ensembl peptide - ENSP00000303351
Ensembl peptide - ENSP00000379350
Ensembl peptide - ENSP00000388694
Ensembl peptide - ENSP00000398029
Ensembl peptide - ENSP00000400544
Ensembl peptide - ENSP00000404546
NCBI entrez gene - 3688     See in Manteia.
OMIM - 135630
RefSeq - NM_002211
RefSeq - NM_033668
RefSeq - NM_133376
RefSeq Peptide - NP_391988
RefSeq Peptide - NP_596867
RefSeq Peptide - NP_002202
swissprot - C9JNE0
swissprot - C9JJP8
swissprot - H7C4K3
swissprot - H7C4N8
swissprot - P05556
swissprot - Q5T3E4
swissprot - Q5T3E5
swissprot - E9PQJ2
swissprot - Q5T3E6
swissprot - E9PLR6
swissprot - E7EUI6
swissprot - E7ERX5
swissprot - E7EQW5
swissprot - C9JPK5
Ensembl - ENSG00000150093
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01058721.1ENSDARG00000109929Danio rerio
 itgb1aENSDARG00000071863Danio rerio
 itgb1bENSDARG00000104484Danio rerio
 ITGB1ENSGALG00000007145Gallus gallus
 Itgb1ENSMUSG00000025809Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGB2 / P05107 / integrin subunit beta 2ENSG0000016025544
ITGB3 / P05106 / integrin subunit beta 3ENSG0000025920742
AC068234.1ENSG0000025975342
ITGB7 / P26010 / integrin subunit beta 7ENSG0000013962642
ITGB5 / P18084 / integrin subunit beta 5ENSG0000008278141
ITGB6 / P18564 / integrin subunit beta 6ENSG0000011522140
ITGB4 / P16144 / integrin subunit beta 4ENSG0000013247035
ITGB8 / P26012 / integrin subunit beta 8ENSG0000010585532
ITGBL1 / O95965 / integrin subunit beta like 1ENSG0000019854214


Protein motifs (from Interpro)
Interpro ID Name
 IPR002369  Integrin beta subunit, VWA domain
 IPR012896  Integrin beta subunit, tail
 IPR013111  EGF-like domain, extracellular
 IPR014836  Integrin beta subunit, cytoplasmic domain
 IPR015812  Integrin beta subunit
 IPR016201  PSI domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR027071  Integrin beta-1 subunit
 IPR032695  Integrin domain superfamily
 IPR033760  Integrin beta N-terminal
 IPR036349  Integrin beta tail domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily
 IPR037076  Integrin beta subunit, cytoplasmic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001708 cell fate specification IEA
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0006968 cellular defense response TAS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules TAS
 biological_processGO:0007159 leukocyte cell-cell adhesion IDA
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0007161 calcium-independent cell-matrix adhesion IGI
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008354 germ cell migration IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0010710 regulation of collagen catabolic process IDA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016477 cell migration TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0021943 formation of radial glial scaffolds IEA
 biological_processGO:0030183 B cell differentiation IC
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031589 cell-substrate adhesion IMP
 biological_processGO:0031623 receptor internalization ISS
 biological_processGO:0033627 cell adhesion mediated by integrin IDA
 biological_processGO:0033631 cell-cell adhesion mediated by integrin IEP
 biological_processGO:0034113 heterotypic cell-cell adhesion IMP
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process IGI
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0045214 sarcomere organization IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0048333 mesodermal cell differentiation IEP
 biological_processGO:0048675 axon extension IEA
 biological_processGO:0048738 cardiac muscle tissue development IEA
 biological_processGO:0048813 dendrite morphogenesis IEA
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0050901 leukocyte tethering or rolling IMP
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus ISS
 biological_processGO:0071711 basement membrane organization IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IDA
 biological_processGO:2000273 positive regulation of signaling receptor activity IDA
 biological_processGO:2000811 negative regulation of anoikis IMP
 cellular_componentGO:0001726 ruffle TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0008305 integrin complex NAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0032587 ruffle membrane IDA
 cellular_componentGO:0034665 integrin alpha1-beta1 complex IDA
 cellular_componentGO:0034666 integrin alpha2-beta1 complex IDA
 cellular_componentGO:0034667 integrin alpha3-beta1 complex IDA
 cellular_componentGO:0034677 integrin alpha7-beta1 complex IEA
 cellular_componentGO:0034678 integrin alpha8-beta1 complex TAS
 cellular_componentGO:0034680 integrin alpha10-beta1 complex IDA
 cellular_componentGO:0034681 integrin alpha11-beta1 complex IDA
 cellular_componentGO:0035748 myelin sheath abaxonal region IEA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071438 invadopodium membrane IEA
 cellular_componentGO:0097060 synaptic membrane IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0001968 fibronectin binding IPI
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015026 coreceptor activity TAS
 molecular_functionGO:0019960 C-X3-C chemokine binding IDA
 molecular_functionGO:0043236 laminin binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity NAS
 molecular_functionGO:0050839 cell adhesion molecule binding IPI
 molecular_functionGO:0098639 collagen binding involved in cell-matrix adhesion IMP


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Fibronectin matrix formation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Basigin interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
Other semaphorin interactions
Signal transduction by L1
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
CHL1 interactions
RHO GTPases Activate Formins
Interleukin-4 and Interleukin-13 signaling
Platelet Adhesion to exposed collagen
MET activates PTK2 signaling
MET interacts with TNS proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105664 COMP / P49747 / cartilage oligomeric matrix protein  / complex / reaction
 ENSG00000109072 VTN / P04004 / vitronectin  / reaction / complex
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / reaction / complex
 ENSG00000131746 TNS4 / Q8IZW8 / tensin 4  / complex
 ENSG00000115232 ITGA4 / P13612 / integrin subunit alpha 4  / complex
 ENSG00000118785 SPP1 / P10451 / secreted phosphoprotein 1  / reaction / complex
 ENSG00000138448 ITGAV / P06756 / integrin subunit alpha V  / complex
 ENSG00000137801 THBS1 / P07996 / thrombospondin 1  / complex / reaction
 ENSG00000139329 LUM / P51884 / lumican  / reaction / complex
 ENSG00000058085 LAMC2 / Q13753 / laminin subunit gamma 2  / complex / reaction
 ENSG00000144668 ITGA9 / Q13797 / integrin subunit alpha 9  / complex
 ENSG00000135424 ITGA7 / Q13683 / integrin subunit alpha 7  / complex
 ENSG00000162692 VCAM1 / P19320 / vascular cell adhesion molecule 1  / complex / reaction
 ENSG00000140678 ITGAX / P20702 / integrin subunit alpha X  / complex
 ENSG00000164171 ITGA2 / P17301 / integrin subunit alpha 2  / complex
 ENSG00000154721 JAM2 / P57087 / junctional adhesion molecule 2  / reaction / complex
 ENSG00000053747 LAMA3 / Q16787 / laminin subunit alpha 3  / reaction / complex
 ENSG00000166086 JAM3 / Q9BX67 / junctional adhesion molecule 3  / reaction / complex
 ENSG00000161638 ITGA5 / P08648 / integrin subunit alpha 5  / complex
 ENSG00000091136 LAMB1 / P07942 / laminin subunit beta 1  / reaction / complex
 ENSG00000166333 ILK / Q13418 / integrin linked kinase  / reaction / complex
 ENSG00000188157 AGRN / agrin / O00468  / complex / reaction
 ENSG00000138623 O75326 / SEMA7A / semaphorin 7A (John Milton Hagen blood group)  / reaction / complex
 ENSG00000166147 FBN1 / P35555 / fibrillin 1  / reaction / complex
 ENSG00000152591 DSPP / Q9NZW4 / dentin sialophosphoprotein  / reaction / complex
 ENSG00000115414 FN1 / P02751 / fibronectin 1  / complex / reaction
 ENSG00000135862 LAMC1 / P11047 / laminin subunit gamma 1  / reaction / complex
 ENSG00000172270 BSG / P35613 / basigin (Ok blood group)  / reaction / complex
 ENSG00000134121 CHL1 / O00533 / cell adhesion molecule L1 like  / reaction / complex
 ENSG00000005884 ITGA3 / P26006 / integrin subunit alpha 3  / complex
 ENSG00000041982 TNC / P24821 / tenascin C  / complex / reaction
 ENSG00000142798 HSPG2 / P98160 / heparan sulfate proteoglycan 2  / complex / reaction
 ENSG00000130702 LAMA5 / O15230 / laminin subunit alpha 5  / reaction / complex
 ENSG00000196878 LAMB3 / Q13751 / laminin subunit beta 3  / complex / reaction
 ENSG00000091409 ITGA6 / P23229 / integrin subunit alpha 6  / complex
 ENSG00000213949 ITGA1 / P56199 / integrin subunit alpha 1  / complex
 ENSG00000172037 LAMB2 / P55268 / laminin subunit beta 2  / reaction / complex
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex / reaction
 ENSG00000137809 ITGA11 / Q9UKX5 / integrin subunit alpha 11  / complex
 ENSG00000143127 ITGA10 / O75578 / integrin subunit alpha 10  / complex
 ENSG00000077943 ITGA8 / P53708 / integrin subunit alpha 8  / complex






 

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