ENSG00000082781


Homo sapiens

Features
Gene ID: ENSG00000082781
  
Biological name :ITGB5
  
Synonyms : integrin subunit beta 5 / ITGB5 / P18084
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q21.2
Gene start: 124761948
Gene end: 124901418
  
Corresponding Affymetrix probe sets: 201124_at (Human Genome U133 Plus 2.0 Array)   201125_s_at (Human Genome U133 Plus 2.0 Array)   214020_x_at (Human Genome U133 Plus 2.0 Array)   214021_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000477446
Ensembl peptide - ENSP00000476655
Ensembl peptide - ENSP00000477230
Ensembl peptide - ENSP00000296181
Ensembl peptide - ENSP00000418079
Ensembl peptide - ENSP00000418367
Ensembl peptide - ENSP00000419198
Ensembl peptide - ENSP00000420814
NCBI entrez gene - 3693     See in Manteia.
OMIM - 147561
RefSeq - XM_017006355
RefSeq - NM_001354764
RefSeq - NM_001354765
RefSeq - NM_002213
RefSeq - XM_005247436
RefSeq - XM_006713630
RefSeq - XM_017006351
RefSeq - XM_017006352
RefSeq - XM_017006353
RefSeq - XM_017006354
RefSeq Peptide - NP_002204
RefSeq Peptide - NP_001341693
RefSeq Peptide - NP_001341694
swissprot - H7C4W1
swissprot - H7C580
swissprot - H7C5U2
swissprot - L7RT22
swissprot - V9GYZ1
swissprot - V9GZ57
swissprot - F8WBG2
swissprot - P18084
swissprot - V9GYD8
Ensembl - ENSG00000082781
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgb5ENSDARG00000012942Danio rerio
 ITGB5ENSGALG00000029766Gallus gallus
 Itgb5ENSMUSG00000022817Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGB3 / P05106 / integrin subunit beta 3ENSG0000025920755
AC068234.1ENSG0000025975353
ITGB6 / P18564 / integrin subunit beta 6ENSG0000011522147
ITGB1 / P05556 / integrin subunit beta 1ENSG0000015009341
ITGB2 / P05107 / integrin subunit beta 2ENSG0000016025537
ITGB7 / P26010 / integrin subunit beta 7ENSG0000013962637
ITGB4 / P16144 / integrin subunit beta 4ENSG0000013247034
ITGB8 / P26012 / integrin subunit beta 8ENSG0000010585533
ITGBL1 / O95965 / integrin subunit beta like 1ENSG0000019854215


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR002369  Integrin beta subunit, VWA domain
 IPR012896  Integrin beta subunit, tail
 IPR013111  EGF-like domain, extracellular
 IPR014836  Integrin beta subunit, cytoplasmic domain
 IPR015812  Integrin beta subunit
 IPR016201  PSI domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR027067  Integrin beta-5 subunit
 IPR032695  Integrin domain superfamily
 IPR033760  Integrin beta N-terminal
 IPR036349  Integrin beta tail domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily
 IPR037076  Integrin beta subunit, cytoplasmic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
 biological_processGO:0006936 muscle contraction TAS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0035987 endodermal cell differentiation IEP
 biological_processGO:0043149 stress fiber assembly IMP
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0090136 epithelial cell-cell adhesion IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034684 integrin alphav-beta5 complex IDA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0045335 phagocytic vesicle TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Cross-presentation of particulate exogenous antigens (phagosomes)
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
ECM proteoglycans
Smooth Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109072 VTN / P04004 / vitronectin  / complex / reaction
 ENSG00000118785 SPP1 / P10451 / secreted phosphoprotein 1  / reaction / complex
 ENSG00000138448 ITGAV / P06756 / integrin subunit alpha V  / complex






 

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