ENSG00000118785


Homo sapiens

Features
Gene ID: ENSG00000118785
  
Biological name :SPP1
  
Synonyms : P10451 / secreted phosphoprotein 1 / SPP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q22.1
Gene start: 87975650
Gene end: 87983426
  
Corresponding Affymetrix probe sets: 1568574_x_at (Human Genome U133 Plus 2.0 Array)   209875_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422973
Ensembl peptide - ENSP00000378517
Ensembl peptide - ENSP00000237623
Ensembl peptide - ENSP00000477824
Ensembl peptide - ENSP00000354042
NCBI entrez gene - 6696     See in Manteia.
OMIM - 166490
RefSeq - NM_001251830
RefSeq - NM_000582
RefSeq - NM_001040058
RefSeq - NM_001040060
RefSeq - NM_001251829
RefSeq Peptide - NP_000573
RefSeq Peptide - NP_001238759
RefSeq Peptide - NP_001238758
RefSeq Peptide - NP_001035149
RefSeq Peptide - NP_001035147
swissprot - P10451
swissprot - A0A024RDE2
swissprot - A0A024RDE6
swissprot - A0A024RDJ0
swissprot - D6R9C5
swissprot - F2YQ21
Ensembl - ENSG00000118785
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPP1ENSGALG00000010926Gallus gallus
 Spp1ENSMUSG00000029304Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002038  Osteopontin
 IPR019841  Osteopontin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001649 osteoblast differentiation IBA
 biological_processGO:0006710 androgen catabolic process IDA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0007566 embryo implantation TAS
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0031214 biomineral tissue development IEA
 biological_processGO:0033280 response to vitamin D IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045780 positive regulation of bone resorption IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0046697 decidualization TAS
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0048685 negative regulation of collateral sprouting of intact axon in response to injury IEA
 biological_processGO:0071394 cellular response to testosterone stimulus IDA
 biological_processGO:2000866 positive regulation of estradiol secretion IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0050840 extracellular matrix binding IBA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Signaling by PDGF
Integrin cell surface interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RUNX3 Regulates Immune Response and Cell Migration
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138448 ITGAV / P06756 / integrin subunit alpha V  / complex / reaction
 ENSG00000144668 ITGA9 / Q13797 / integrin subunit alpha 9  / reaction / complex
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / complex / reaction
 ENSG00000082781 ITGB5 / P18084 / integrin subunit beta 5  / reaction / complex
 ENSG00000115232 ITGA4 / P13612 / integrin subunit alpha 4  / complex / reaction
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / complex / reaction
 ENSG00000161638 ITGA5 / P08648 / integrin subunit alpha 5  / complex / reaction
 ENSG00000077943 ITGA8 / P53708 / integrin subunit alpha 8  / reaction / complex
 ENSG00000026508 CD44 / P16070 / CD44 molecule (Indian blood group)  / reaction / complex
 ENSG00000137673 MMP7 / P09237 / matrix metallopeptidase 7  / reaction
 ENSG00000149968 MMP3 / P08254 / matrix metallopeptidase 3  / reaction
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / complex / reaction
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / reaction / complex






 

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