ENSG00000197461


Homo sapiens

Features
Gene ID: ENSG00000197461
  
Biological name :PDGFA
  
Synonyms : P04085 / PDGFA / platelet derived growth factor subunit A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p22.3
Gene start: 497258
Gene end: 520296
  
Corresponding Affymetrix probe sets: 205463_s_at (Human Genome U133 Plus 2.0 Array)   216867_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000384673
Ensembl peptide - ENSP00000346508
Ensembl peptide - ENSP00000383572
Ensembl peptide - ENSP00000383889
NCBI entrez gene - 5154     See in Manteia.
OMIM - 173430
RefSeq - XM_017012289
RefSeq - XM_011515415
RefSeq - XM_011515416
RefSeq - XM_011515417
RefSeq - XM_011515418
RefSeq - XM_011515419
RefSeq - NM_002607
RefSeq - NM_033023
RefSeq Peptide - NP_002598
RefSeq Peptide - NP_148983
swissprot - H7BYW6
swissprot - P04085
swissprot - A0A0A0MSC4
Ensembl - ENSG00000197461
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdgfaaENSDARG00000109371Danio rerio
 pdgfaaENSDARG00000110069Danio rerio
 pdgfabENSDARG00000098578Danio rerio
 PDGFAENSGALG00000003642Gallus gallus
 PdgfaENSMUSG00000025856Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDGFB / P01127 / platelet derived growth factor subunit BENSG0000010031141


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR006782  Platelet-derived growth factor, N-terminal
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0001525 angiogenesis ISS
 biological_processGO:0001775 cell activation TAS
 biological_processGO:0001942 hair follicle development ISS
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation ISS
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0009611 response to wounding IDA
 biological_processGO:0009887 animal organ morphogenesis ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010512 negative regulation of phosphatidylinositol biosynthetic process IDA
 biological_processGO:0010544 negative regulation of platelet activation IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0014910 regulation of smooth muscle cell migration IDA
 biological_processGO:0030031 cell projection assembly ISS
 biological_processGO:0030036 actin cytoskeleton organization ISS
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IDA
 biological_processGO:0032956 regulation of actin cytoskeleton organization TAS
 biological_processGO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway IDA
 biological_processGO:0042060 wound healing TAS
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0043588 skin development ISS
 biological_processGO:0045740 positive regulation of DNA replication IDA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IDA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IDA
 biological_processGO:0048286 lung alveolus development ISS
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0050919 negative chemotaxis IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0060683 regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:1990401 embryonic lung development ISS
 biological_processGO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway TAS
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005902 microvillus ISS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IDA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0048407 platelet-derived growth factor binding IPI


Pathways (from Reactome)
Pathway description
Non-integrin membrane-ECM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000050820 BCAR1 / P56945 / BCAR1, Cas family scaffolding protein  / reaction / complex
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / reaction / complex
 ENSG00000127947 PTPN12 / Q05209 / protein tyrosine phosphatase, non-receptor type 12  / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000134853 P16234 / PDGFRA / platelet derived growth factor receptor alpha  / complex
 ENSG00000113721 P09619 / PDGFRB / platelet derived growth factor receptor beta  / complex
 ENSG00000140564 FURIN / P09958 / furin, paired basic amino acid cleaving enzyme  / reaction
 ENSG00000141738 GRB7 / Q14451 / growth factor receptor bound protein 7  / reaction / complex
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / complex / reaction
 ENSG00000186340 THBS2 / P35442 / thrombospondin 2  / reaction / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000169231 THBS3 / P49746 / thrombospondin 3  / complex / reaction
 ENSG00000099942 CRKL / P46109 / CRK like proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / reaction / complex
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / reaction / complex
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction / complex
 ENSG00000158092 NCK1 / P16333 / NCK adaptor protein 1  / reaction / complex
 ENSG00000137801 THBS1 / P07996 / thrombospondin 1  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000118785 SPP1 / P10451 / secreted phosphoprotein 1  / complex / reaction
 ENSG00000113296 THBS4 / P35443 / thrombospondin 4  / reaction / complex
 ENSG00000107263 Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr