ENSG00000140564


Homo sapiens

Features
Gene ID: ENSG00000140564
  
Biological name :FURIN
  
Synonyms : FURIN / furin, paired basic amino acid cleaving enzyme / P09958
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q26.1
Gene start: 90868592
Gene end: 90883458
  
Corresponding Affymetrix probe sets: 201945_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453942
Ensembl peptide - ENSP00000483552
Ensembl peptide - ENSP00000491453
Ensembl peptide - ENSP00000484952
Ensembl peptide - ENSP00000268171
Ensembl peptide - ENSP00000452730
Ensembl peptide - ENSP00000453212
NCBI entrez gene - 5045     See in Manteia.
OMIM - 136950
RefSeq - NM_001289824
RefSeq - NM_002569
RefSeq - NM_001289823
RefSeq Peptide - NP_001276752
RefSeq Peptide - NP_001276753
RefSeq Peptide - NP_002560
swissprot - P09958
swissprot - A0A024RC70
swissprot - H0YKB2
swissprot - H0YLH7
swissprot - H0YNB5
swissprot - A0A1W2PPZ9
Ensembl - ENSG00000140564
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 furinaENSDARG00000062909Danio rerio
 furinbENSDARG00000070971Danio rerio
 FURINENSGALG00000008341Gallus gallus
 FurinENSMUSG00000030530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PCSK4 / Q6UW60 / proprotein convertase subtilisin/kexin type 4ENSG0000011525750
PCSK5 / Q92824 / proprotein convertase subtilisin/kexin type 5ENSG0000009913947
PCSK6 / P29122 / proprotein convertase subtilisin/kexin type 6ENSG0000014047945
PCSK1 / P29120 / proprotein convertase subtilisin/kexin type 1ENSG0000017542641
PCSK2 / P16519 / proprotein convertase subtilisin/kexin type 2ENSG0000012585136
PCSK7 / Q16549 / proprotein convertase subtilisin/kexin type 7ENSG0000016061334


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR002884  P domain
 IPR006212  Furin-like repeat
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032815  Peptidase S8, pro-domain
 IPR034182  Kexin/furin catalytic domain
 IPR036852  Peptidase S8/S53 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006465 signal peptide processing IDA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0016485 protein processing IMP
 biological_processGO:0016486 peptide hormone processing IDA
 biological_processGO:0019058 viral life cycle IEP
 biological_processGO:0019082 viral protein processing TAS
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030574 collagen catabolic process TAS
 biological_processGO:0031638 zymogen activation IMP
 biological_processGO:0032455 nerve growth factor processing TAS
 biological_processGO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process IDA
 biological_processGO:0032902 nerve growth factor production IDA
 biological_processGO:0032911 negative regulation of transforming growth factor beta1 production IMP
 biological_processGO:0032940 secretion by cell IDA
 biological_processGO:0042176 regulation of protein catabolic process IMP
 biological_processGO:0043043 peptide biosynthetic process IDA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045714 regulation of low-density lipoprotein particle receptor biosynthetic process IEA
 biological_processGO:0051004 regulation of lipoprotein lipase activity TAS
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis IC
 biological_processGO:0052548 regulation of endopeptidase activity IDA
 biological_processGO:0070268 cornification TAS
 biological_processGO:0090472 dibasic protein processing IMP
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IGI
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030140 trans-Golgi network transport vesicle IDA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004175 endopeptidase activity TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048406 nerve growth factor binding IDA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Collagen degradation
Elastic fibre formation
Activation of Matrix Metalloproteinases
Removal of aminoterminal propeptides from gamma-carboxylated proteins
NGF processing
Synthesis and processing of ENV and VPU
Signaling by PDGF
Pre-NOTCH Processing in Golgi
TGF-beta receptor signaling activates SMADs
Uptake and function of anthrax toxins
Formation of the cornified envelope
Assembly of active LPL and LIPC lipase complexes
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000143631 FLG / P20930 / filaggrin  / reaction
 ENSG00000157227 MMP14 / P50281 / matrix metallopeptidase 14  / reaction
 ENSG00000148400 NOTCH1 / P46531  / reaction
 ENSG00000101981 F9 / P00740 / coagulation factor IX  / reaction
 ENSG00000156103 MMP16 / P51512 / matrix metallopeptidase 16  / reaction
 ENSG00000126231 PROZ / P22891 / protein Z, vitamin K dependent plasma glycoprotein  / reaction
 ENSG00000169604 ANTXR1 / Q9H6X2 / anthrax toxin receptor 1  / reaction
 ENSG00000175445 LPL / P06858 / lipoprotein lipase  / reaction
 ENSG00000242252 BGLAP / P02818 / bone gamma-carboxyglutamate protein  / reaction
 ENSG00000115718 PROC / P04070 / protein C, inactivator of coagulation factors Va and VIIIa  / reaction
 ENSG00000099953 MMP11 / P24347 / matrix metallopeptidase 11  / reaction
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / reaction
 ENSG00000166147 FBN1 / P35555 / fibrillin 1  / reaction
 ENSG00000156574 NODAL / Q96S42 / nodal growth differentiation factor  / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / reaction
 ENSG00000105329 TGFB1 / P01137 / transforming growth factor beta 1  / reaction
 ENSG00000184500 PROS1 / P07225 / protein S  / reaction
 ENSG00000163297 ANTXR2 / P58335 / anthrax toxin receptor 2  / reaction
 ENSG00000183087 GAS6 / Q14393 / growth arrest specific 6  / reaction
 ENSG00000138829 FBN2 / P35556 / fibrillin 2  / reaction
 ENSG00000277494 Q8IV16 / GPIHBP1 / glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1  / reaction
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / reaction
 ENSG00000126218 F10 / P00742 / coagulation factor X  / reaction
 ENSG00000057593 F7 / P08709 / coagulation factor VII  / reaction
 ENSG00000180210 F2 / P00734 / coagulation factor II, thrombin  / reaction






 

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