ENSG00000099139


Homo sapiens

Features
Gene ID: ENSG00000099139
  
Biological name :PCSK5
  
Synonyms : PCSK5 / proprotein convertase subtilisin/kexin type 5 / Q92824
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q21.13
Gene start: 75890644
Gene end: 76362339
  
Corresponding Affymetrix probe sets: 205559_s_at (Human Genome U133 Plus 2.0 Array)   205560_at (Human Genome U133 Plus 2.0 Array)   213652_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000446280
Ensembl peptide - ENSP00000365958
Ensembl peptide - ENSP00000407239
Ensembl peptide - ENSP00000411654
Ensembl peptide - ENSP00000365943
NCBI entrez gene - 5125     See in Manteia.
OMIM - 600488
RefSeq - XM_017014800
RefSeq - NM_001190482
RefSeq - NM_006200
RefSeq - XM_005252039
RefSeq - XM_011518769
RefSeq - XM_011518770
RefSeq Peptide - NP_001177411
RefSeq Peptide - NP_006191
swissprot - Q5JSG7
swissprot - B1AMG8
swissprot - Q92824
swissprot - B1AMG5
Ensembl - ENSG00000099139
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcsk5aENSDARG00000067537Danio rerio
 pcsk5bENSDARG00000060518Danio rerio
 ENSGALG00000033256Gallus gallus
 ENSGALG00000015164Gallus gallus
 Pcsk5ENSMUSG00000024713Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PCSK6 / P29122 / proprotein convertase subtilisin/kexin type 6ENSG0000014047927
FURIN / P09958 / furin, paired basic amino acid cleaving enzymeENSG0000014056420
PCSK4 / Q6UW60 / proprotein convertase subtilisin/kexin type 4ENSG0000011525718
PCSK1 / P29120 / proprotein convertase subtilisin/kexin type 1ENSG0000017542617
PCSK7 / Q16549 / proprotein convertase subtilisin/kexin type 7ENSG0000016061315
PCSK2 / P16519 / proprotein convertase subtilisin/kexin type 2ENSG0000012585115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR000742  EGF-like domain
 IPR002884  P domain
 IPR006212  Furin-like repeat
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR010909  PLAC
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032778  Growth factor receptor domain 4
 IPR032815  Peptidase S8, pro-domain
 IPR034182  Kexin/furin catalytic domain
 IPR036852  Peptidase S8/S53 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0002001 renin secretion into blood stream IEP
 biological_processGO:0003279 cardiac septum development IEA
 biological_processGO:0006465 signal peptide processing IDA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0016486 peptide hormone processing IEA
 biological_processGO:0019058 viral life cycle IEA
 biological_processGO:0030323 respiratory tube development ISS
 biological_processGO:0032455 nerve growth factor processing TAS
 biological_processGO:0035108 limb morphogenesis IEA
 biological_processGO:0042089 cytokine biosynthetic process ISS
 biological_processGO:0043043 peptide biosynthetic process IEA
 biological_processGO:0048566 embryonic digestive tract development IEA
 biological_processGO:0048706 embryonic skeletal system development IEA
 biological_processGO:0051004 regulation of lipoprotein lipase activity TAS
 biological_processGO:0060976 coronary vasculature development IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030141 secretory granule IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IEA


Pathways (from Reactome)
Pathway description
NGF processing
Assembly of active LPL and LIPC lipase complexes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134259 NGF / P01138 / nerve growth factor  / reaction
 ENSG00000277494 Q8IV16 / GPIHBP1 / glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1  / reaction
 ENSG00000175445 LPL / P06858 / lipoprotein lipase  / reaction






 

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