ENSG00000134259


Homo sapiens

Features
Gene ID: ENSG00000134259
  
Biological name :NGF
  
Synonyms : nerve growth factor / NGF / P01138
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p13.2
Gene start: 115285918
Gene end: 115338236
  
Corresponding Affymetrix probe sets: 206814_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358525
NCBI entrez gene - 4803     See in Manteia.
OMIM - 162030
RefSeq - NM_002506
RefSeq - XM_006710663
RefSeq Peptide - NP_002497
swissprot - P01138
Ensembl - ENSG00000134259
  
Related genetic diseases (OMIM): 608654 - Neuropathy, hereditary sensory and autonomic, type V, 608654
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ngfaENSDARG00000058961Danio rerio
 ngfbENSDARG00000014050Danio rerio
 NGFENSGALG00000002556Gallus gallus
 NgfENSMUSG00000027859Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NTF3 / P20783 / neurotrophin 3ENSG0000018565242
BDNF / P23560 / brain derived neurotrophic factorENSG0000017669736
NTF4 / P34130 / neurotrophin 4ENSG0000022595031


Protein motifs (from Interpro)
Interpro ID Name
 IPR002072  Nerve growth factor-related
 IPR019846  Nerve growth factor conserved site
 IPR020408  Nerve growth factor-like
 IPR020425  Nerve growth factor, beta subunit
 IPR020437  Nerve growth factor, beta subunit, mammalian
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity TAS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
 biological_processGO:0007018 microtubule-based movement TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IDA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0032455 nerve growth factor processing TAS
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process TAS
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process TAS
 biological_processGO:0043388 positive regulation of DNA binding ISS
 biological_processGO:0043524 negative regulation of neuron apoptotic process IBA
 biological_processGO:0045664 regulation of neuron differentiation IBA
 biological_processGO:0045666 positive regulation of neuron differentiation TAS
 biological_processGO:0046579 positive regulation of Ras protein signal transduction ISS
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway TAS
 biological_processGO:0048015 phosphatidylinositol-mediated signaling TAS
 biological_processGO:0048812 neuron projection morphogenesis IDA
 biological_processGO:0050772 positive regulation of axonogenesis TAS
 cellular_componentGO:0005576 extracellular region IBA
 cellular_componentGO:0005768 endosome TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IBA
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005163 nerve growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
PLC-gamma1 signalling
Signalling to RAS
NGF processing
Frs2-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
TRKA activation by NGF
Signalling to p38 via RIT and RIN
NRAGE signals death through JNK
p75NTR negatively regulates cell cycle via SC1
Ceramide signalling
PI3K/AKT activation
Signalling to STAT3
NFG and proNGF binds to p75NTR
NADE modulates death signalling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000742 Self-mutilation 
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 HP:0000970 Anhidrosis "Inability to sweat." [HPO:curators]
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 HP:0001226 Acral ulceration and osteomyelitis leading to autoamputation of the digits 
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 HP:0001256 Mental retardation, mild "Mild mental retardation is defined as an intelligence quotient (IQ) in the range of 50-69." [HPO:curators]
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 HP:0001862 Acral ulceration and osteomyelitis leading to autoamputation of the digits (feet) 
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 HP:0001954 Fever, episodic "Periodic (episodic or recurrent) bouts of fever that do not have an infectious cause." [HPO:curators]
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 HP:0002661 Painless fractures due to injury "An increased tendency to fractures following trauma, with fractures occurring without pain." [HPO:curators]
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 HP:0003593 Early onset 
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 HP:0007021 Pain insensitivity, diffuse 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000064300 NGFR / P08138 / nerve growth factor receptor  / reaction / complex
 ENSG00000100246 DNAL4 / O96015 / dynein axonemal light chain 4  / reaction
 ENSG00000110851 PRDM4 / Q9UKN5 / PR/SET domain 4  / reaction / complex
 ENSG00000104312 RIPK2 / O43353 / receptor interacting serine/threonine kinase 2  / complex / reaction
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / reaction / complex
 ENSG00000205155 PSENEN / Q9NZ42 / presenilin enhancer gamma-secretase subunit  / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / reaction / complex
 ENSG00000117362 APH1A / Q96BI3 / aph-1 homolog A, gamma-secretase subunit  / reaction
 ENSG00000134313 Q9ULH0 / KIDINS220 / kinase D interacting substrate 220  / complex / reaction
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000129946 SHC2 / P98077 / SHC adaptor protein 2  / complex / reaction
 ENSG00000138613 APH1B / Q8WW43 / aph-1 homolog B, gamma-secretase subunit  / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / complex / reaction
 ENSG00000141522 P52565 / ARHGDIA / Rho GDP dissociation inhibitor alpha  / complex / reaction
 ENSG00000140564 FURIN / P09958 / furin, paired basic amino acid cleaving enzyme  / reaction
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000169047 IRS1 / P35568 / insulin receptor substrate 1  / complex / reaction
 ENSG00000142856 Q13352 / ITGB3BP / integrin subunit beta 3 binding protein  / reaction / complex
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / reaction / complex
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / reaction / complex
 ENSG00000163558 PRKCI / P41743 / protein kinase C iota  / reaction / complex
 ENSG00000162736 NCSTN / Q92542 / nicastrin  / reaction
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / reaction / complex
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / complex / reaction
 ENSG00000140479 PCSK6 / P29122 / proprotein convertase subtilisin/kexin type 6  / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / complex / reaction
 ENSG00000179222 MAGED1 / Q9Y5V3 / MAGE family member D1  / reaction / complex
 ENSG00000152214 RIT2 / Q99578 / Ras like without CAAX 2  / complex / reaction
 ENSG00000080815 PSEN1 / P49768 / presenilin 1  / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / reaction / complex
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / complex / reaction
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / complex / reaction
 ENSG00000161011 Q13501 / SQSTM1 / sequestosome 1  / complex / reaction
 ENSG00000166681 BEX3 / Q00994 / brain expressed X-linked 3  / reaction / complex
 ENSG00000099942 CRKL / P46109 / CRK like proto-oncogene, adaptor protein  / reaction / complex
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / reaction / complex
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / reaction / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex
 ENSG00000108953 YWHAE / P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon  / complex / reaction
 ENSG00000107263 Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000166225 FRS2 / Q8WU20 / fibroblast growth factor receptor substrate 2  / reaction / complex
 ENSG00000135587 SMPD2 / O60906 / sphingomyelin phosphodiesterase 2  / reaction
 ENSG00000275700 AATF / Q9NY61 / apoptosis antagonizing transcription factor  / reaction / complex
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / reaction
 ENSG00000143622 RIT1 / Q92963 / Ras like without CAAX 1  / reaction / complex
 ENSG00000143801 PSEN2 / P49810 / presenilin 2  / reaction
 ENSG00000148082 SHC3 / Q92529 / SHC adaptor protein 3  / complex / reaction
 ENSG00000099139 PCSK5 / Q92824 / proprotein convertase subtilisin/kexin type 5  / reaction
 ENSG00000185950 IRS2 / Q9Y4H2 / insulin receptor substrate 2  / complex / reaction
 ENSG00000107295 Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1  / complex / reaction
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / reaction / complex
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / reaction / complex






 

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