ENSG00000104312


Homo sapiens

Features
Gene ID: ENSG00000104312
  
Biological name :RIPK2
  
Synonyms : O43353 / receptor interacting serine/threonine kinase 2 / RIPK2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q21.3
Gene start: 89757747
Gene end: 89791063
  
Corresponding Affymetrix probe sets: 209544_at (Human Genome U133 Plus 2.0 Array)   209545_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000220751
Ensembl peptide - ENSP00000429271
Ensembl peptide - ENSP00000427736
NCBI entrez gene - 8767     See in Manteia.
OMIM - 603455
RefSeq - NM_003821
RefSeq - XM_011517357
RefSeq - XM_005251092
RefSeq Peptide - NP_003812
swissprot - E7ERW9
swissprot - O43353
swissprot - A0A0S2Z4Z8
swissprot - E5RGK6
Ensembl - ENSG00000104312
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ripk2ENSDARG00000104290Danio rerio
 RIPK2ENSGALG00000043535Gallus gallus
 Ripk2ENSMUSG00000041135Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RIPK4 / P57078 / receptor interacting serine/threonine kinase 4ENSG0000018342128
ANKK1 / Q8NFD2 / ankyrin repeat and kinase domain containing 1ENSG0000017020928
RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1ENSG0000013727521
RIPK3 / Q9Y572 / receptor interacting serine/threonine kinase 3ENSG0000012946521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001315  CARD domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR017322  Receptor-interacting serine/threonine-protein kinase 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IBA
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0001961 positive regulation of cytokine-mediated signaling pathway IEA
 biological_processGO:0002250 adaptive immune response IBA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0007254 JNK cascade TAS
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA
 biological_processGO:0010942 positive regulation of cell death IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination NAS
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032092 positive regulation of protein binding IMP
 biological_processGO:0032722 positive regulation of chemokine production IEA
 biological_processGO:0032727 positive regulation of interferon-alpha production NAS
 biological_processGO:0032728 positive regulation of interferon-beta production NAS
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032735 positive regulation of interleukin-12 production NAS
 biological_processGO:0032743 positive regulation of interleukin-2 production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IEA
 biological_processGO:0033091 positive regulation of immature T cell proliferation IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0034134 toll-like receptor 2 signaling pathway IDA
 biological_processGO:0034142 toll-like receptor 4 signaling pathway IEA
 biological_processGO:0042098 T cell proliferation IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043330 response to exogenous dsRNA IEA
 biological_processGO:0045087 innate immune response ISS
 biological_processGO:0045627 positive regulation of T-helper 1 cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II NAS
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0050852 T cell receptor signaling pathway ISS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
 biological_processGO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway IEA
 biological_processGO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0070671 response to interleukin-12 IEA
 biological_processGO:0070673 response to interleukin-18 IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071223 cellular response to lipoteichoic acid IEA
 biological_processGO:0071224 cellular response to peptidoglycan IEA
 biological_processGO:0071225 cellular response to muramyl dipeptide IDA
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity IDA
 biological_processGO:1904417 positive regulation of xenophagy IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0032991 protein-containing complex IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030274 LIM domain binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0050700 CARD domain binding IDA
 molecular_functionGO:0089720 caspase binding IPI


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
Downstream TCR signaling
p75NTR recruits signalling complexes
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Ovarian tumor domain proteases
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104312 RIPK2 / O43353 / receptor interacting serine/threonine kinase 2  / reaction / complex
 ENSG00000198286 CARD11 / Q9BXL7 / caspase recruitment domain family member 11  / reaction
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / reaction / complex
 ENSG00000167207 NOD2 / Q9HC29 / nucleotide binding oligomerization domain containing 2  / complex / reaction
 ENSG00000135341 MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7  / reaction / complex
 ENSG00000055208 TAB2 / Q9NYJ8 / TGF-beta activated kinase 1/MAP3K7 binding protein 2  / reaction / complex
 ENSG00000100324 TAB1 / Q15750 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1  / reaction / complex
 ENSG00000134259 NGF / P01138 / nerve growth factor  / reaction / complex
 ENSG00000157625 TAB3 / Q8N5C8 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3  / reaction / complex
 ENSG00000064300 NGFR / P08138 / nerve growth factor receptor  / reaction / complex
 ENSG00000187796 CARD9 / Q9H257 / caspase recruitment domain family member 9  / complex / reaction
 ENSG00000142867 BCL10 / O95999 / B cell CLL/lymphoma 10  / reaction
 ENSG00000140992 PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1  / reaction
 ENSG00000106100 NOD1 / Q9Y239 / nucleotide binding oligomerization domain containing 1  / complex / reaction
 ENSG00000118503 P21580 / TNFAIP3 / TNF alpha induced protein 3  / reaction
 ENSG00000083799 CYLD / Q9NQC7 / CYLD lysine 63 deubiquitinase  / reaction






 

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