ENSMUSG00000041135


Mus musculus

Features
Gene ID: ENSMUSG00000041135
  
Biological name :Ripk2
  
Synonyms : P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / Ripk2
  
Possible biological names infered from orthology : O43353 / receptor interacting serine/threonine kinase 2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A2
Gene start: 16122733
Gene end: 16163647
  
Corresponding Affymetrix probe sets: 10511703 (MoGene1.0st)   1421236_at (Mouse Genome 430 2.0 Array)   1450173_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038833
Ensembl peptide - ENSMUSP00000139381
NCBI entrez gene - 192656     See in Manteia.
MGI - MGI:1891456
RefSeq - XM_006537679
RefSeq - NM_138952
RefSeq - XM_006537677
RefSeq - XM_006537678
RefSeq Peptide - NP_620402
swissprot - V9GXY4
swissprot - P58801
swissprot - Q547H1
Ensembl - ENSMUSG00000041135
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ripk2ENSDARG00000104290Danio rerio
 RIPK2ENSGALG00000043535Gallus gallus
 RIPK2ENSG00000104312Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ripk4 / Q9ERK0 / Receptor-interacting serine/threonine-protein kinase 4 / P57078* / receptor interacting serine/threonine kinase 4*ENSMUSG0000000525127
Ankk1 / Q8BZ25 / Ankyrin repeat and protein kinase domain-containing protein 1 / Q8NFD2* / ankyrin repeat and kinase domain containing 1*ENSMUSG0000003225726
Ripk3 / Q9QZL0 / receptor-interacting serine-threonine kinase 3 / Q9Y572*ENSMUSG0000002222121
Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*ENSMUSG0000002140821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001315  CARD domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR017322  Receptor-interacting serine/threonine-protein kinase 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001961 positive regulation of cytokine-mediated signaling pathway IMP
 biological_processGO:0002250 adaptive immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IMP
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032722 positive regulation of chemokine production IMP
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0032743 positive regulation of interleukin-2 production IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IMP
 biological_processGO:0033091 positive regulation of immature T cell proliferation IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034134 toll-like receptor 2 signaling pathway IEA
 biological_processGO:0034142 toll-like receptor 4 signaling pathway IMP
 biological_processGO:0042098 T cell proliferation IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043330 response to exogenous dsRNA IMP
 biological_processGO:0045087 innate immune response ISO
 biological_processGO:0045627 positive regulation of T-helper 1 cell differentiation IMP
 biological_processGO:0046330 positive regulation of JNK cascade IMP
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IMP
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway IMP
 biological_processGO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
 biological_processGO:0070555 response to interleukin-1 IMP
 biological_processGO:0070671 response to interleukin-12 IMP
 biological_processGO:0070673 response to interleukin-18 IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0071223 cellular response to lipoteichoic acid IMP
 biological_processGO:0071224 cellular response to peptidoglycan IMP
 biological_processGO:0071225 cellular response to muramyl dipeptide IEA
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity IEA
 biological_processGO:1904417 positive regulation of xenophagy IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030274 LIM domain binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0050700 CARD domain binding IEA
 molecular_functionGO:0089720 caspase binding IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
Downstream TCR signaling
p75NTR recruits signalling complexes
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Ovarian tumor domain proteases
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Tnip1tm1.1Pcoh/Tnip1tm1.1Pcoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ripk2tm1Flv/Ripk2tm1Flv,Tnip1tm1.1Pcoh/Tnip1tm1.1Pcoh
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ripk2tm1Flv/Ripk2tm1Flv,Tnip1tm1.1Pcoh/Tnip1tm1.1Pcoh
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002406 increased susceptibility to infection "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitW-ei/Kit+
Genetic Background: C57BL-KitW-ei

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C57BL/6-Ins2Akita/J

Allelic Composition: Ripk2tm1Flv/Ripk2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Lystbg-slt/Lystbg-slt,Myo5ad/Myo5ad
Genetic Background: involves: CT/Ch * YZ57/Ch

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lystbg-slt/Lystbg-slt,Myo5ad/Myo5ad
Genetic Background: involves: CT/Ch * YZ57/Ch

Allelic Composition: Ripk2tm1Ghc/Ripk2tm1Ghc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lystbg-slt/Lystbg-slt,Myo5ad/Myo5ad
Genetic Background: involves: CT/Ch * YZ57/Ch

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ripk2tm1Ghc/Ripk2tm1Ghc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Lystbg-slt/Lystbg-slt,Myo5ad/Myo5ad
Genetic Background: involves: CT/Ch * YZ57/Ch

Allelic Composition: Ripk2tm1Flv/Ripk2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ripk2tm1Ghc/Ripk2tm1Ghc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Lystbg-slt/Lystbg-slt,Myo5ad/Myo5ad
Genetic Background: involves: CT/Ch * YZ57/Ch

Allelic Composition: Ripk2tm1Flv/Ripk2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000120 Ngfr / nerve growth factor receptor / P08138*  / reaction / complex
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSMUSG00000019850 Q60769 / Tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / TNF alpha induced protein 3*  / reaction
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / complex / reaction
 ENSMUSG00000036712 Cyld / Q80TQ2 / Ubiquitin carboxyl-terminal hydrolase CYLD / Q9NQC7* / CYLD lysine 63 deubiquitinase*  / reaction
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / reaction / complex
 ENSMUSG00000036526 Card11 / Q8CIS0 / Caspase recruitment domain-containing protein 11 / Q9BXL7* / caspase recruitment domain family member 11*  / reaction
 ENSMUSG00000028191 Bcl10 / Q9Z0H7 / B-cell lymphoma/leukemia 10 / O95999* / B cell CLL/lymphoma 10*  / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / complex / reaction
 ENSMUSG00000041135 Ripk2 / P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / O43353* / receptor interacting serine/threonine kinase 2*  / complex / reaction
 ENSMUSG00000035476 Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / reaction
 ENSMUSG00000026928 Card9 / A2AIV8 / Caspase recruitment domain-containing protein 9 / Q9H257* / caspase recruitment domain family member 9*  / reaction / complex
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / reaction / complex
 ENSMUSG00000055994 Nod2 / Q8K3Z0 / Nucleotide-binding oligomerization domain-containing protein 2 / Q9HC29* / nucleotide binding oligomerization domain containing 2*  / complex / reaction
 ENSMUSG00000038058 Nod1 / Q8BHB0 / Nucleotide-binding oligomerization domain-containing protein 1 / Q9Y239* / nucleotide binding oligomerization domain containing 1*  / reaction / complex






 

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