ENSMUSG00000022414


Mus musculus

Features
Gene ID: ENSMUSG00000022414
  
Biological name :Tab1
  
Synonyms : Q8CF89 / Tab1 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
  
Possible biological names infered from orthology : Q15750 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 80133127
Gene end: 80161707
  
Corresponding Affymetrix probe sets: 10425341 (MoGene1.0st)   1426898_at (Mouse Genome 430 2.0 Array)   1447692_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023050
Ensembl peptide - ENSMUSP00000155204
NCBI entrez gene - 66513     See in Manteia.
MGI - MGI:1913763
RefSeq - XM_006521259
RefSeq - NM_025609
RefSeq Peptide - NP_079885
swissprot - Q8CF89
Ensembl - ENSMUSG00000022414
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tab1ENSDARG00000036613Danio rerio
 TAB1ENSGALG00000012150Gallus gallus
 TAB1ENSG00000100324Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001932  PPM-type phosphatase domain
 IPR015655  Protein phosphatase 2C family
 IPR036457  PPM-type phosphatase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000185 activation of MAPKKK activity IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003279 cardiac septum development IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0035904 aorta development IMP
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0060976 coronary vasculature development IMP
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019209 kinase activator activity IMP
 molecular_functionGO:0048273 mitogen-activated protein kinase p38 binding IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
Show

Allelic Composition: Smarca4b2b508.1Clo/Smarca4b2b508.1Clo
Genetic Background: C57BL/6J-Smarca4b2b508.1Clo

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0000279 ventricular hypoplasia "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Tab1tm1.1Mis/Tab1tm1.1Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Smarca4b2b508.1Clo/Smarca4b2b508.1Clo
Genetic Background: C57BL/6J-Smarca4b2b508.1Clo

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Pigatm1Bsl/Y,Tg(FES-cre)31Bsl/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA/Ca

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Tab1tm1.1Mis/Tab1tm1.1Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tnfrsf1atm1Mak/Tnfrsf1atm1Mak,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Tab1tm1.1Mis/Tab1tm1.1Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smarca4b2b508.1Clo/Smarca4b2b508.1Clo
Genetic Background: C57BL/6J-Smarca4b2b508.1Clo

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0002747 abnormal aortic valve morphology "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smarca4b2b508.1Clo/Smarca4b2b508.1Clo
Genetic Background: C57BL/6J-Smarca4b2b508.1Clo

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Smarca4b2b508.1Clo/Smarca4b2b508.1Clo
Genetic Background: C57BL/6J-Smarca4b2b508.1Clo

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Smarca4b2b508.1Clo/Smarca4b2b508.1Clo
Genetic Background: C57BL/6J-Smarca4b2b508.1Clo

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0009698 heart hemorrhage "bleeding into the heart" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0009873 abnormal aorta tunica media morphology "any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Smarca4b2b508.1Clo/Smarca4b2b508.1Clo
Genetic Background: C57BL/6J-Smarca4b2b508.1Clo

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tab1tm1.1Mis/Tab1tm1.1Mis
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction / complex
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex / reaction
 ENSMUSG00000036526 Card11 / Q8CIS0 / Caspase recruitment domain-containing protein 11 / Q9BXL7* / caspase recruitment domain family member 11*  / reaction / complex
 ENSMUSG00000028191 Bcl10 / Q9Z0H7 / B-cell lymphoma/leukemia 10 / O95999* / B cell CLL/lymphoma 10*  / reaction / complex
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / complex / reaction
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / reaction / complex
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / reaction / complex
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / reaction / complex
 ENSMUSG00000032688 Malt1 / Q2TBA3 / Mucosa-associated lymphoid tissue lymphoma translocation / Q9UDY8* / MALT1 paracaspase*  / complex / reaction
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / reaction / complex
 ENSMUSG00000026928 Card9 / A2AIV8 / Caspase recruitment domain-containing protein 9 / Q9H257* / caspase recruitment domain family member 9*  / complex / reaction
 ENSMUSG00000041135 Ripk2 / P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / O43353* / receptor interacting serine/threonine kinase 2*  / complex / reaction
 ENSMUSG00000038058 Nod1 / Q8BHB0 / Nucleotide-binding oligomerization domain-containing protein 1 / Q9Y239* / nucleotide binding oligomerization domain containing 1*  / complex / reaction
 ENSMUSG00000060477 Irak2 / Q8CFA1 / Interleukin-1 receptor-associated kinase-like 2 / O43187* / interleukin 1 receptor associated kinase 2*  / complex / reaction
 ENSMUSG00000026778 Prkcq / Q02111 / protein kinase C, theta / Q04759*  / reaction / complex
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / reaction / complex
 ENSMUSG00000055994 Nod2 / Q8K3Z0 / Nucleotide-binding oligomerization domain-containing protein 2 / Q9HC29* / nucleotide binding oligomerization domain containing 2*  / complex / reaction
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / complex / reaction
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / reaction / complex
 ENSMUSG00000030107 Usp18 / Q9WTV6 / ubiquitin specific peptidase 18 / USP41* / Q9UMW8* / Q3LFD5* / ubiquitin specific peptidase 41*  / complex
 ENSMUSG00000033352 Map2k4 / P47809 / Dual specificity mitogen-activated protein kinase kinase 4 / P45985* / mitogen-activated protein kinase kinase 4*  / reaction
 ENSMUSG00000035476 Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / reaction / complex






 

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