ENSMUSG00000031392


Mus musculus

Features
Gene ID: ENSMUSG00000031392
  
Biological name :Irak1
  
Synonyms : Interleukin-1 receptor-associated kinase 1 / Irak1 / Q62406
  
Possible biological names infered from orthology : P51617
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A7.3
Gene start: 74013914
Gene end: 74023918
  
Corresponding Affymetrix probe sets: 10605222 (MoGene1.0st)   1438120_x_at (Mouse Genome 430 2.0 Array)   1438857_x_at (Mouse Genome 430 2.0 Array)   1448668_a_at (Mouse Genome 430 2.0 Array)   1460649_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116167
Ensembl peptide - ENSMUSP00000122519
Ensembl peptide - ENSMUSP00000121016
Ensembl peptide - ENSMUSP00000118570
Ensembl peptide - ENSMUSP00000117379
Ensembl peptide - ENSMUSP00000117042
Ensembl peptide - ENSMUSP00000033769
Ensembl peptide - ENSMUSP00000064448
Ensembl peptide - ENSMUSP00000099001
Ensembl peptide - ENSMUSP00000109992
Ensembl peptide - ENSMUSP00000109993
Ensembl peptide - ENSMUSP00000109994
Ensembl peptide - ENSMUSP00000110000
Ensembl peptide - ENSMUSP00000115508
NCBI entrez gene - 16179     See in Manteia.
MGI - MGI:107420
RefSeq - NM_001177976
RefSeq - NM_008363
RefSeq - NM_001177975
RefSeq - NM_001177973
RefSeq - NM_001177974
RefSeq Peptide - NP_001171447
RefSeq Peptide - NP_032389
RefSeq Peptide - NP_001171444
RefSeq Peptide - NP_001171445
RefSeq Peptide - NP_001171446
swissprot - Q62406
swissprot - B1AUW9
swissprot - Q8BR10
swissprot - B1AUW8
swissprot - B1AUW6
swissprot - B1AUW1
swissprot - B1AUV9
swissprot - F6THK7
swissprot - F6TQF4
swissprot - F6ZGQ1
swissprot - F7ANU5
swissprot - F7CUT1
swissprot - Q540G0
Ensembl - ENSMUSG00000031392
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irak1ENSDARG00000025949Danio rerio
 IRAK1ENSG00000184216Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irak2 / Q8CFA1 / Interleukin-1 receptor-associated kinase-like 2 / O43187* / interleukin 1 receptor associated kinase 2*ENSMUSG0000006047723
Irak3 / Q8K4B2 / Mus musculus interleukin-1 receptor-associated kinase 3 (Irak3), transcript variant 2, mRNA. / Q9Y616* / interleukin 1 receptor associated kinase 3*ENSMUSG0000002022722
Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*ENSMUSG0000005988318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR035533  Interleukin-1 receptor-associated kinase 1, death domain
 IPR035536  Interleukin-1 receptor-associated kinase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001959 regulation of cytokine-mediated signaling pathway IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IEA
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032481 positive regulation of type I interferon production IEA
 biological_processGO:0032494 response to peptidoglycan IDA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0034134 toll-like receptor 2 signaling pathway IEA
 biological_processGO:0034142 toll-like receptor 4 signaling pathway IDA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IMP
 biological_processGO:0043507 positive regulation of JUN kinase activity IMP
 biological_processGO:0045087 innate immune response IEP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0060337 type I interferon signaling pathway IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0090370 negative regulation of cholesterol efflux IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005149 interleukin-1 receptor binding IPI
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
IRAK1 recruits IKK complex
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: B6(C)-H2-Ab1bm12/KhEgJ

Allelic Composition: Irak1tm1Jth/Y,Tg(Myh6-Tnf)1Brgi/?
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001856 myocarditis "inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: B6(C)-H2-Ab1bm12/KhEgJ

Allelic Composition: Irak1tm1Jth/Y,Tg(Myh6-Tnf)1Brgi/?
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col8a2tm1.1Asj/Col8a2tm1.1Asj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Irak1tm1.1Pcoh/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Irak1tm1Jth/Y,Irak2tm1Aki/Irak2tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tyrp1rgsc799/Tyrp1rgsc799
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: B6(C)-H2-Ab1bm12/KhEgJ

Allelic Composition: Irak1tm1Jth/Y,Tg(Myh6-Tnf)1Brgi/?
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdnftm1Lfr/Bdnftm1Lfr
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Irak1tm1Jth/Y
Genetic Background: B6.Cg-Irak1tm1Jth

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Mavstm1Zjc/Mavs+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Kmt2atm1Sjk/Kmt2atm1Sjk
Genetic Background: involves: 129S2/SvPas * CD-1

Allelic Composition: Irak1tm1.1Pcoh/?,Irak2tm1.1Pcoh/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Irak1tm1Jth/Y,Irak2tm1Aki/Irak2tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0013155 decreased KLRG1+ CD8 alpha beta T cell number "decrease in the number of CD8+ alpha beta T cells that express KLRG1, a marker of effector and memory T cells" [MGI:csmith]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000120 Ngfr / nerve growth factor receptor / P08138*  / complex
 ENSMUSG00000025139 Q9QZ06 / Tollip / toll interacting protein / Q9H0E2*  / complex / reaction
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex / reaction
 ENSMUSG00000015837 Q64337 / Sqstm1 / Sequestosome-1 / Q13501*  / reaction / complex
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / complex / reaction
 ENSMUSG00000025498 Irf7 / P70434 / interferon regulatory factor 7 / Q92985*  / reaction / complex
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / complex / reaction
 ENSMUSG00000026072 Il1r1 / P13504 / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form / P14778* / interleukin 1 receptor type 1*  / complex / reaction
 ENSMUSG00000024901 Peli3 / E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 / Q8N2H9* / pellino E3 ubiquitin protein ligase family member 3*  / complex / reaction
 ENSMUSG00000022514 Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*  / complex / reaction
 ENSMUSG00000024810 Il33 / Q8BVZ5 / Interleukin-33 Interleukin-33(102-266) Interleukin-33(109-266) / O95760* / interleukin 33*  / complex
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / reaction / complex
 ENSMUSG00000027398 Il1b / P10749 / Interleukin-1 beta / P01584*  / complex / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / complex / reaction
 ENSMUSG00000037643 Prkci / Q62074 / protein kinase C, iota / P41743*  / complex / reaction
 ENSMUSG00000040522 Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*  / complex / reaction
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex / reaction
 ENSMUSG00000045322 Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*  / complex / reaction
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / complex
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / complex / reaction
 ENSMUSG00000020134 Peli1 / Q8C669 / pellino 1 / Q96FA3* / pellino E3 ubiquitin protein ligase 1*  / reaction / complex
 ENSMUSG00000044583 Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*  / complex / reaction
 ENSMUSG00000027399 Il1a / P01582 / Interleukin-1 alpha / P01583*  / complex / reaction
 ENSMUSG00000060477 Irak2 / Q8CFA1 / Interleukin-1 receptor-associated kinase-like 2 / O43187* / interleukin 1 receptor associated kinase 2*  / reaction / complex
 ENSMUSG00000021846 Peli2 / pellino E3 ubiquitin protein ligase family member 2 / Q9HAT8*  / reaction / complex
 ENSMUSG00000026069 Il1rl1 / P14719 / Interleukin-1 receptor-like 1 / Q01638*  / complex
 ENSMUSG00000035476 Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / reaction / complex






 

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