ENSG00000184216


Homo sapiens

Features
Gene ID: ENSG00000184216
  
Biological name :IRAK1
  
Synonyms : interleukin 1 receptor associated kinase 1 / IRAK1 / P51617
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q28
Gene start: 154010500
Gene end: 154019980
  
Corresponding Affymetrix probe sets: 1555784_s_at (Human Genome U133 Plus 2.0 Array)   201587_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000410953
Ensembl peptide - ENSP00000406249
Ensembl peptide - ENSP00000411809
Ensembl peptide - ENSP00000358990
Ensembl peptide - ENSP00000358991
Ensembl peptide - ENSP00000358997
Ensembl peptide - ENSP00000377291
Ensembl peptide - ENSP00000392662
Ensembl peptide - ENSP00000399974
Ensembl peptide - ENSP00000403730
NCBI entrez gene - 3654     See in Manteia.
OMIM - 300283
RefSeq - XM_011531158
RefSeq - NM_001025242
RefSeq - NM_001025243
RefSeq - NM_001569
RefSeq - XM_005274668
RefSeq Peptide - NP_001020413
RefSeq Peptide - NP_001020414
RefSeq Peptide - NP_001560
swissprot - D3YTB5
swissprot - F8WAB6
swissprot - H7C1F0
swissprot - H7C224
swissprot - H7C3C1
swissprot - H7C2I6
swissprot - H7C3G8
swissprot - P51617
Ensembl - ENSG00000184216
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irak1ENSDARG00000025949Danio rerio
 Irak1ENSMUSG00000031392Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IRAK2 / O43187 / interleukin 1 receptor associated kinase 2ENSG0000013407026
IRAK3 / Q9Y616 / interleukin 1 receptor associated kinase 3ENSG0000009037623
IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4ENSG0000019800119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR035533  Interleukin-1 receptor-associated kinase 1, death domain
 IPR035536  Interleukin-1 receptor-associated kinase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0001959 regulation of cytokine-mediated signaling pathway IMP
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway NAS
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IDA
 biological_processGO:0007254 JNK cascade TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0032481 positive regulation of type I interferon production IMP
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0034134 toll-like receptor 2 signaling pathway IMP
 biological_processGO:0034142 toll-like receptor 4 signaling pathway IBA
 biological_processGO:0034162 toll-like receptor 9 signaling pathway TAS
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043406 positive regulation of MAP kinase activity IBA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
 biological_processGO:0051259 protein complex oligomerization IMP
 biological_processGO:0060337 type I interferon signaling pathway IMP
 biological_processGO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 biological_processGO:0070555 response to interleukin-1 IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005811 lipid droplet ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0045323 interleukin-1 receptor complex NAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004704 NF-kappaB-inducing kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
MyD88:Mal cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
IRAK1 recruits IKK complex
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000064300 NGFR / P08138 / nerve growth factor receptor  / complex / reaction
 ENSG00000196083 IL1RAP / Q9NPH3 / interleukin 1 receptor accessory protein  / complex / reaction
 ENSG00000100324 TAB1 / Q15750 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1  / complex / reaction
 ENSG00000101916 TLR8 / Q9NR97 / toll like receptor 8  / complex / reaction
 ENSG00000125538 IL1B / P01584 / interleukin 1 beta  / complex / reaction
 ENSG00000078902 Q9H0E2 / TOLLIP / toll interacting protein  / reaction / complex
 ENSG00000134070 IRAK2 / O43187 / interleukin 1 receptor associated kinase 2  / complex / reaction
 ENSG00000137462 TLR2 / O60603 / toll like receptor 2  / complex / reaction
 ENSG00000115008 IL1A / P01583 / interleukin 1 alpha  / complex / reaction
 ENSG00000157625 TAB3 / Q8N5C8 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3  / reaction / complex
 ENSG00000174123 TLR10 / Q9BXR5 / toll like receptor 10  / complex / reaction
 ENSG00000139946 PELI2 / Q9HAT8 / pellino E3 ubiquitin protein ligase family member 2  / complex / reaction
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / complex / reaction
 ENSG00000135218 CD36 / P16671 / CD36 molecule  / complex / reaction
 ENSG00000174125 TLR1 / Q15399 / toll like receptor 1  / complex / reaction
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / complex / reaction
 ENSG00000163558 PRKCI / P41743 / protein kinase C iota  / complex / reaction
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / complex / reaction
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / reaction / complex
 ENSG00000244687 Q13404 / UBE2V1 / ubiquitin conjugating enzyme E2 V1  / reaction / complex
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / complex / reaction
 ENSG00000174516 PELI3 / Q8N2H9 / pellino E3 ubiquitin protein ligase family member 3  / reaction / complex
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / reaction / complex
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / complex / reaction
 ENSG00000197329 PELI1 / Q96FA3 / pellino E3 ubiquitin protein ligase 1  / reaction / complex
 ENSG00000161011 Q13501 / SQSTM1 / sequestosome 1  / complex / reaction
 ENSG00000239732 TLR9 / Q9NR96 / toll like receptor 9  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000196664 TLR7 / Q9NYK1 / toll like receptor 7  / reaction / complex
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / reaction / complex
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / reaction / complex
 ENSG00000187554 TLR5 / O60602 / toll like receptor 5  / complex / reaction
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / reaction / complex
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / reaction / complex
 ENSG00000137033 IL33 / O95760 / interleukin 33  / complex
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / reaction / complex
 ENSG00000150455 TIRAP / P58753 / TIR domain containing adaptor protein  / complex / reaction
 ENSG00000115602 IL1RL1 / Q01638 / interleukin 1 receptor like 1  / complex
 ENSG00000174130 TLR6 / Q9Y2C9 / toll like receptor 6  / complex / reaction
 ENSG00000135341 MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7  / complex / reaction
 ENSG00000055208 TAB2 / Q9NYJ8 / TGF-beta activated kinase 1/MAP3K7 binding protein 2  / reaction / complex
 ENSG00000115594 IL1R1 / P14778 / interleukin 1 receptor type 1  / reaction / complex






 

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