ENSG00000125538


Homo sapiens

Features
Gene ID: ENSG00000125538
  
Biological name :IL1B
  
Synonyms : IL1B / interleukin 1 beta / P01584
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q14.1
Gene start: 112829751
Gene end: 112836903
  
Corresponding Affymetrix probe sets: 205067_at (Human Genome U133 Plus 2.0 Array)   39402_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263341
Ensembl peptide - ENSP00000409680
Ensembl peptide - ENSP00000407219
Ensembl peptide - ENSP00000400854
NCBI entrez gene - 3553     See in Manteia.
OMIM - 147720
RefSeq - NM_000576
RefSeq - XM_017003988
RefSeq Peptide - NP_000567
swissprot - C9JSC2
swissprot - C9JWV2
swissprot - P01584
swissprot - C9JVK0
Ensembl - ENSG00000125538
  
Related genetic diseases (OMIM): 137215 - {Gastric cancer risk after H. pylori infection}, 137215
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il1bENSDARG00000098700Danio rerio
 IL1BENSGALG00000029940Gallus gallus
 Il1bENSMUSG00000027398Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000975  Interleukin-1 family
 IPR003296  Interleukin-1 beta
 IPR003502  Interleukin-1 propeptide
 IPR008996  Cytokine IL1/FGF
 IPR020877  Interleukin-1 conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IMP
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0001660 fever generation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation NAS
 biological_processGO:0002711 positive regulation of T cell mediated immunity IC
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007566 embryo implantation TAS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0009743 response to carbohydrate IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IDA
 biological_processGO:0010829 negative regulation of glucose transmembrane transport ISS
 biological_processGO:0014805 smooth muscle adaptation NAS
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0030213 hyaluronan biosynthetic process IDA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0030730 sequestering of triglyceride IDA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IC
 biological_processGO:0031622 positive regulation of fever generation IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0032308 positive regulation of prostaglandin secretion IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032611 interleukin-1 beta production IEA
 biological_processGO:0032635 interleukin-6 production IEA
 biological_processGO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IDA
 biological_processGO:0032729 positive regulation of interferon-gamma production IDA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IDA
 biological_processGO:0033129 positive regulation of histone phosphorylation NAS
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0034116 positive regulation of heterotypic cell-cell adhesion NAS
 biological_processGO:0035066 positive regulation of histone acetylation NAS
 biological_processGO:0035234 ectopic germ cell programmed cell death IEA
 biological_processGO:0035505 positive regulation of myosin light chain kinase activity IDA
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0045080 positive regulation of chemokine biosynthetic process IEA
 biological_processGO:0045086 positive regulation of interleukin-2 biosynthetic process IMP
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IDA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045833 negative regulation of lipid metabolic process ISS
 biological_processGO:0045840 positive regulation of mitotic nuclear division IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway ISS
 biological_processGO:0046827 positive regulation of protein export from nucleus NAS
 biological_processGO:0050691 regulation of defense response to virus by host IEA
 biological_processGO:0050766 positive regulation of phagocytosis IMP
 biological_processGO:0050796 regulation of insulin secretion IDA
 biological_processGO:0050805 negative regulation of synaptic transmission IEA
 biological_processGO:0050900 leukocyte migration IEA
 biological_processGO:0050995 negative regulation of lipid catabolic process IDA
 biological_processGO:0050996 positive regulation of lipid catabolic process ISS
 biological_processGO:0050999 regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060355 positive regulation of cell adhesion molecule production NAS
 biological_processGO:0060559 positive regulation of calcidiol 1-monooxygenase activity IDA
 biological_processGO:0070164 negative regulation of adiponectin secretion ISS
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0070487 monocyte aggregation IDA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:0071310 cellular response to organic substance IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IDA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:1903140 regulation of establishment of endothelial barrier IDA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005149 interleukin-1 receptor binding IEA
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-1 processing
CLEC7A/inflammasome pathway
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000196083 IL1RAP / Q9NPH3 / interleukin 1 receptor accessory protein  / complex / reaction
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / reaction / complex
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000115594 IL1R1 / P14778 / interleukin 1 receptor type 1  / reaction / complex
 ENSG00000078902 Q9H0E2 / TOLLIP / toll interacting protein  / complex / reaction
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / reaction
 ENSG00000115590 IL1R2 / P27930 / interleukin 1 receptor type 2  / complex / reaction
 ENSG00000137752 CASP1 / P29466 / caspase 1  / reaction






 

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