ENSG00000115590


Homo sapiens

Features
Gene ID: ENSG00000115590
  
Biological name :IL1R2
  
Synonyms : IL1R2 / interleukin 1 receptor type 2 / P27930
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q11.2
Gene start: 101991844
Gene end: 102028544
  
Corresponding Affymetrix probe sets: 205403_at (Human Genome U133 Plus 2.0 Array)   211372_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000414611
Ensembl peptide - ENSP00000330959
Ensembl peptide - ENSP00000377066
Ensembl peptide - ENSP00000408415
NCBI entrez gene - 7850     See in Manteia.
OMIM - 147811
RefSeq - XM_017004889
RefSeq - NM_001261419
RefSeq - NM_004633
RefSeq - XM_011511803
RefSeq - XM_011511804
RefSeq - XM_011511805
RefSeq - XM_011511807
RefSeq - XM_006712734
RefSeq - XM_006712736
RefSeq - XM_011511801
RefSeq Peptide - NP_001248348
RefSeq Peptide - NP_004624
swissprot - P27930
swissprot - C9JNR0
Ensembl - ENSG00000115590
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01078737.1ENSDARG00000100461Danio rerio
 IL1R2ENSGALG00000046326Gallus gallus
 Il1r2ENSMUSG00000026073Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IL1R1 / P14778 / interleukin 1 receptor type 1ENSG0000011559425
Q9NP60 / IL1RAPL2 / interleukin 1 receptor accessory protein like 2ENSG0000018910824
IL1RL2 / Q9HB29 / interleukin 1 receptor like 2ENSG0000011559822
Q9NZN1 / IL1RAPL1 / interleukin 1 receptor accessory protein like 1ENSG0000016930621
IL1RAP / Q9NPH3 / interleukin 1 receptor accessory proteinENSG0000019608319
O95256 / IL18RAP / interleukin 18 receptor accessory proteinENSG0000011560718
IL1RL1 / Q01638 / interleukin 1 receptor like 1ENSG0000011560218
IL18R1 / Q13478 / interleukin 18 receptor 1ENSG0000011560415


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR004074  Interleukin-1 receptor type I/II
 IPR004077  Interleukin-1 receptor type II
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response TAS
 biological_processGO:0010955 negative regulation of protein processing IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0050712 negative regulation of interleukin-1 alpha secretion IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:1900016 negative regulation of cytokine production involved in inflammatory response IEA
 biological_processGO:2000660 negative regulation of interleukin-1-mediated signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004908 interleukin-1 receptor activity TAS
 molecular_functionGO:0004910 interleukin-1, type II, blocking receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019966 interleukin-1 binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-10 signaling
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136689 IL1RN / P18510 / interleukin 1 receptor antagonist  / reaction / complex
 ENSG00000125538 IL1B / P01584 / interleukin 1 beta  / complex / reaction
 ENSG00000115008 IL1A / P01583 / interleukin 1 alpha  / reaction / complex






 

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