ENSG00000115008


Homo sapiens

Features
Gene ID: ENSG00000115008
  
Biological name :IL1A
  
Synonyms : IL1A / interleukin 1 alpha / P01583
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q14.1
Gene start: 112773915
Gene end: 112784590
  
Corresponding Affymetrix probe sets: 208200_at (Human Genome U133 Plus 2.0 Array)   210118_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263339
NCBI entrez gene - 3552     See in Manteia.
OMIM - 147760
RefSeq - NM_000575
RefSeq Peptide - NP_000566
swissprot - P01583
Ensembl - ENSG00000115008
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Il1aENSMUSG00000027399Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000975  Interleukin-1 family
 IPR003295  Interleukin-1 alpha
 IPR003502  Interleukin-1 propeptide
 IPR008996  Cytokine IL1/FGF
 IPR020877  Interleukin-1 conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001660 fever generation IEA
 biological_processGO:0002248 connective tissue replacement involved in inflammatory response wound healing IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0034605 cellular response to heat IDA
 biological_processGO:0035234 ectopic germ cell programmed cell death IEA
 biological_processGO:0045086 positive regulation of interleukin-2 biosynthetic process IMP
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046688 response to copper ion IDA
 biological_processGO:0050714 positive regulation of protein secretion IMP
 biological_processGO:0050715 positive regulation of cytokine secretion IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:2000391 positive regulation of neutrophil extravasation IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005125 cytokine activity IMP
 molecular_functionGO:0005149 interleukin-1 receptor binding IBA
 molecular_functionGO:0005507 copper ion binding IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Senescence-Associated Secretory Phenotype (SASP)
Interleukin-1 processing
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000078902 Q9H0E2 / TOLLIP / toll interacting protein  / reaction / complex
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / reaction / complex
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000115594 IL1R1 / P14778 / interleukin 1 receptor type 1  / reaction / complex
 ENSG00000196083 IL1RAP / Q9NPH3 / interleukin 1 receptor accessory protein  / complex / reaction
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / complex / reaction
 ENSG00000115590 IL1R2 / P27930 / interleukin 1 receptor type 2  / complex / reaction






 

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