ENSMUSG00000027399


Mus musculus

Features
Gene ID: ENSMUSG00000027399
  
Biological name :Il1a
  
Synonyms : Il1a / Interleukin-1 alpha / P01582
  
Possible biological names infered from orthology : P01583
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 129299610
Gene end: 129309972
  
Corresponding Affymetrix probe sets: 10487588 (MoGene1.0st)   1421473_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028882
NCBI entrez gene - 16175     See in Manteia.
MGI - MGI:96542
RefSeq - XM_006498794
RefSeq - NM_010554
RefSeq - XM_006498793
RefSeq Peptide - NP_034684
swissprot - Q3U0Y6
swissprot - P01582
Ensembl - ENSMUSG00000027399
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL1AENSG00000115008Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000975  Interleukin-1 family
 IPR003295  Interleukin-1 alpha
 IPR003502  Interleukin-1 propeptide
 IPR008996  Cytokine IL1/FGF
 IPR020877  Interleukin-1 conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001660 fever generation IEA
 biological_processGO:0002248 connective tissue replacement involved in inflammatory response wound healing IMP
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IDA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0035234 ectopic germ cell programmed cell death IGI
 biological_processGO:0045086 positive regulation of interleukin-2 biosynthetic process IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0046688 response to copper ion IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IDA
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IDA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IMP
 biological_processGO:2000391 positive regulation of neutrophil extravasation IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005149 interleukin-1 receptor binding IPI
 molecular_functionGO:0005507 copper ion binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-1 processing
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il1atm1Yiw/Il1atm1Yiw,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Mylktm1.1Bph/Mylktm1.2Bph,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Il1btm1Lvp/Il1btm1Lvp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/10 * RIIIS

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Il1btm1Yiw/Il1btm1Yiw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003829 impaired febrile response "reduced or absent febrile response to exogenous or endogenous pyrogens" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:70534]
Show

Allelic Composition: Il1atm1Yiw/Il1atm1Yiw,Il1btm1Yiw/Il1btm1Yiw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il1atm1Yiw/Il1atm1Yiw,Il1btm1Yiw/Il1btm1Yiw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il1atm1Yiw/Il1atm1Yiw,Il1btm1Yiw/Il1btm1Yiw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008639 decreased circulating interleukin-1 alpha level "reduction in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
Show

Allelic Composition: Plp1jp-4J/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Il1atm1Yiw/Il1atm1Yiw,Il1btm1Yiw/Il1btm1Yiw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008642 decreased circulating interleukin-1 beta level "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Il1atm1Yiw/Il1atm1Yiw,Il1btm1Yiw/Il1btm1Yiw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Plp1jp-4J/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp1tm1Sesh/Casp1tm1Sesh,Casp4del/Casp4del
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il1btm1Lvp/Il1btm1Lvp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/10 * RIIIS

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025139 Q9QZ06 / Tollip / toll interacting protein / Q9H0E2*  / complex / reaction
 ENSMUSG00000026072 Il1r1 / P13504 / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form / P14778* / interleukin 1 receptor type 1*  / reaction / complex
 ENSMUSG00000026073 Il1r2 / P27931 / Interleukin-1 receptor type 2 Interleukin-1 receptor type 2, membrane form Interleukin-1 receptor type 2, soluble form / P27930* / interleukin 1 receptor type 2*  / complex / reaction
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex / reaction
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / reaction / complex
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex / reaction
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / reaction / complex
 ENSMUSG00000022514 Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr