ENSMUSG00000059883


Mus musculus

Features
Gene ID: ENSMUSG00000059883
  
Biological name :Irak4
  
Synonyms : Interleukin-1 receptor-associated kinase 4 / Irak4 / Q8R4K2
  
Possible biological names infered from orthology : Q9NWZ3
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E3
Gene start: 94543643
Gene end: 94581815
  
Corresponding Affymetrix probe sets: 10426451 (MoGene1.0st)   1421670_a_at (Mouse Genome 430 2.0 Array)   1451749_at (Mouse Genome 430 2.0 Array)   1451750_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074471
Ensembl peptide - ENSMUSP00000104871
NCBI entrez gene - 266632     See in Manteia.
MGI - MGI:2182474
RefSeq - NM_029926
RefSeq Peptide - NP_084202
swissprot - Q3USX5
swissprot - Q8R4K2
Ensembl - ENSMUSG00000059883
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IRAK4ENSDARG00000100534Danio rerio
 IRAK4ENSGALG00000009586Gallus gallus
 IRAK4ENSG00000198001Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*ENSMUSG0000003139230
Irak3 / Q8K4B2 / Mus musculus interleukin-1 receptor-associated kinase 3 (Irak3), transcript variant 2, mRNA. / Q9Y616* / interleukin 1 receptor associated kinase 3*ENSMUSG0000002022727
Irak2 / Q8CFA1 / Interleukin-1 receptor-associated kinase-like 2 / O43187* / interleukin 1 receptor associated kinase 2*ENSMUSG0000006047726


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR017428  Interleukin-1 receptor-associated kinase 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IDA
 biological_processGO:0002224 toll-like receptor signaling pathway IBA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002446 neutrophil mediated immunity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IBA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IBA
 biological_processGO:1990266 neutrophil migration IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005149 interleukin-1 receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Irak4tm1Gram/Irak4tm1Gram
Genetic Background: involves: BALB/c

Allelic Composition: Irak4tm1Aki/Irak4tm1Aki
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Irak4tm2Aki/Irak4tm2Aki
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
Show

Allelic Composition: Gria1tm4Rlh/Gria1tm4Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Irak4tm1Aki/Irak4tm1Aki
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Irak4tm2Aki/Irak4tm2Aki
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Efnb1tm1Rha/Efnb1+,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Irak4tm1Lix/Irak4tm1Lix
Genetic Background: involves: C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Irak4tm1Aki/Irak4tm1Aki
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Irak4tm2Aki/Irak4tm2Aki
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Irak4tm1Lix/Irak4tm1Lix
Genetic Background: involves: C57BL/6

Allelic Composition: Irak4m1Btlr/Irak4m1Btlr
Genetic Background: C57BL/6J-Irak4m1Btlr

Allelic Composition: Irak4m1Btlr/Irak4m1Btlr,Ticam1Lps2/Ticam1Lps2
Genetic Background: involves: C57BL/6J

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Irak4tm1Aki/Irak4tm1Aki
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Irak4tm2Aki/Irak4tm2Aki
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Irak4tm1Lix/Irak4tm1Lix
Genetic Background: involves: C57BL/6

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Irak4tm1Lix/Irak4tm1Lix
Genetic Background: involves: C57BL/6

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

 MP:0008592 decreased circulating interleukin-1 level "reduction in the amount in the blood of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens" [MESH:D12.644.276.374.465.501]
Show

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Irak4tm1Lix/Irak4tm1Lix
Genetic Background: involves: C57BL/6

 MP:0008670 decreased interleukin-12b secretion "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Irak4tm1Aki/Irak4tm1Aki
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Irak4tm2Aki/Irak4tm2Aki
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Irak4tm1Aki/Irak4tm1Aki
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Irak4tm2Aki/Irak4tm2Aki
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Irak4tm1Lix/Irak4tm1Lix
Genetic Background: involves: C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Irak4tm1Gram/Irak4tm1Gram
Genetic Background: involves: BALB/c

Allelic Composition: Irak4tm1Lix/Irak4tm1Lix
Genetic Background: involves: C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Irak4tm1Aki/Irak4tm1Aki
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Irak4tm2Aki/Irak4tm2Aki
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Irak4tm1Lix/Irak4tm1Lix
Genetic Background: involves: C57BL/6

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025139 Q9QZ06 / Tollip / toll interacting protein / Q9H0E2*  / reaction / complex
 ENSMUSG00000025498 Irf7 / P70434 / interferon regulatory factor 7 / Q92985*  / reaction / complex
 ENSMUSG00000026072 Il1r1 / P13504 / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form / P14778* / interleukin 1 receptor type 1*  / complex / reaction
 ENSMUSG00000022514 Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*  / reaction / complex
 ENSMUSG00000024810 Il33 / Q8BVZ5 / Interleukin-33 Interleukin-33(102-266) Interleukin-33(109-266) / O95760* / interleukin 33*  / complex
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / complex / reaction
 ENSMUSG00000027398 Il1b / P10749 / Interleukin-1 beta / P01584*  / complex / reaction
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / reaction / complex
 ENSMUSG00000027399 Il1a / P01582 / Interleukin-1 alpha / P01583*  / reaction / complex
 ENSMUSG00000044583 Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*  / reaction / complex
 ENSMUSG00000026069 Il1rl1 / P14719 / Interleukin-1 receptor-like 1 / Q01638*  / complex
 ENSMUSG00000060477 Irak2 / Q8CFA1 / Interleukin-1 receptor-associated kinase-like 2 / O43187* / interleukin 1 receptor associated kinase 2*  / complex / reaction
 ENSMUSG00000045322 Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*  / reaction / complex
 ENSMUSG00000040522 Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*  / complex / reaction
 ENSMUSG00000021846 Peli2 / pellino E3 ubiquitin protein ligase family member 2 / Q9HAT8*  / complex / reaction
 ENSMUSG00000020134 Peli1 / Q8C669 / pellino 1 / Q96FA3* / pellino E3 ubiquitin protein ligase 1*  / complex / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex / reaction
 ENSMUSG00000024901 Peli3 / E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 / Q8N2H9* / pellino E3 ubiquitin protein ligase family member 3*  / complex / reaction
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / reaction / complex






 

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