ENSMUSG00000026069


Mus musculus

Features
Gene ID: ENSMUSG00000026069
  
Biological name :Il1rl1
  
Synonyms : Il1rl1 / Interleukin-1 receptor-like 1 / P14719
  
Possible biological names infered from orthology : Q01638
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 40429570
Gene end: 40465415
  
Corresponding Affymetrix probe sets: 10345791 (MoGene1.0st)   1422317_a_at (Mouse Genome 430 2.0 Array)   1425145_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133784
Ensembl peptide - ENSMUSP00000054914
Ensembl peptide - ENSMUSP00000095379
Ensembl peptide - ENSMUSP00000134225
Ensembl peptide - ENSMUSP00000134351
NCBI entrez gene - 17082     See in Manteia.
MGI - MGI:98427
RefSeq - XM_017319082
RefSeq - NM_001025602
RefSeq - NM_001294171
RefSeq - NM_010743
RefSeq - XM_006495741
RefSeq - XM_006495744
RefSeq Peptide - NP_034873
RefSeq Peptide - NP_001020773
RefSeq Peptide - NP_001281100
swissprot - P14719
swissprot - Q5D095
swissprot - G3UYU3
Ensembl - ENSMUSG00000026069
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01054965.1ENSDARG00000090844Danio rerio
 CU855885.1ENSDARG00000101527Danio rerio
 IL1RL1ENSGALG00000016785Gallus gallus
 IL1RL1ENSG00000115602Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il1r1 / P13504 / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form / P14778* / interleukin 1 receptor type 1*ENSMUSG0000002607227
Q9ERS6 / Il1rapl2 / X-linked interleukin-1 receptor accessory protein-like 2 / Q9NP60* / interleukin 1 receptor accessory protein like 2*ENSMUSG0000005920326
Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*ENSMUSG0000002251426
Il18r1 / Q61098 / Interleukin-18 receptor 1 / Q13478*ENSMUSG0000002607025
Il1rl2 / Q9ERS7 / Mus musculus interleukin 1 receptor-like 2 (Il1rl2), transcript variant 2, mRNA. / Q9HB29* / interleukin 1 receptor like 2*ENSMUSG0000007094225
Il1rapl1 / interleukin 1 receptor accessory protein like 1 / Q9NZN1*ENSMUSG0000005237225
Q9Z2B1 / Il18rap / Interleukin-18 receptor accessory protein / O95256*ENSMUSG0000002606822
Il1r2 / P27931 / Interleukin-1 receptor type 2 Interleukin-1 receptor type 2, membrane form Interleukin-1 receptor type 2, soluble form / P27930* / interleukin 1 receptor type 2*ENSMUSG0000002607315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR004074  Interleukin-1 receptor type I/II
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002826 negative regulation of T-helper 1 type immune response IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IGI
 biological_processGO:0032754 positive regulation of interleukin-5 production IGI
 biological_processGO:0038172 interleukin-33-mediated signaling pathway IEA
 biological_processGO:0043032 positive regulation of macrophage activation IMP
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0050729 positive regulation of inflammatory response IMP
 biological_processGO:0090197 positive regulation of chemokine secretion IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0002113 interleukin-33 binding IPI
 molecular_functionGO:0002114 interleukin-33 receptor activity IPI
 molecular_functionGO:0004908 interleukin-1 receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-33 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hcls1tm2Wtn/Hcls1tm2Wtn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002465 abnormal eosinophil physiology "abnormal function of the leukocyte that stains with eosin and is involved in clearance of parasitic infections and in allergic reactions " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Foxp2tm1Bux/Foxp2+
Genetic Background: involves: C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lmnatm6Lgf/Lmna+,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Il17rbtm1Anjm/Il17rbtm1Anjm,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Foxp2tm1Bux/Foxp2+
Genetic Background: involves: C57BL/6

 MP:0004761 susceptibility to induced pancreatitis "more likely than normal to develop an inflammatory response, or an increased inflammatory response in the pancreatic tissue after experimental manipulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mnttm1Awb/Mnttm1.1Awb,Tg(MMTV-cre)4Mam/?
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmnatm6Lgf/Lmna+,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Il17rbtm1Anjm/Il17rbtm1Anjm,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il13tm3.1Anjm/Il13+,Il17rbtm1Anjm/Il17rbtm1Anjm,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il13tm3.1Anjm/Il13+,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mnttm1Awb/Mnttm1.1Awb,Tg(MMTV-cre)4Mam/?
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17rbtm1Anjm/Il17rbtm1Anjm,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxp2tm1Bux/Foxp2+
Genetic Background: involves: C57BL/6

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Foxp2tm1Bux/Foxp2+
Genetic Background: involves: C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Foxp2tm1Bux/Foxp2+
Genetic Background: involves: C57BL/6

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Foxp2tm1Bux/Foxp2+
Genetic Background: involves: C57BL/6

Allelic Composition: Il1rl1tm1Brl/Il1rl1tm1Brl
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022514 Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*  / complex / reaction
 ENSMUSG00000024810 Il33 / Q8BVZ5 / Interleukin-33 Interleukin-33(102-266) Interleukin-33(109-266) / O95760* / interleukin 33*  / complex / reaction
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / complex
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / complex
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex






 

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