ENSMUSG00000026070


Mus musculus

Features
Gene ID: ENSMUSG00000026070
  
Biological name :Il18r1
  
Synonyms : Il18r1 / Interleukin-18 receptor 1 / Q61098
  
Possible biological names infered from orthology : Q13478
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 40465552
Gene end: 40500854
  
Corresponding Affymetrix probe sets: 10345807 (MoGene1.0st)   1421628_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142070
Ensembl peptide - ENSMUSP00000141464
Ensembl peptide - ENSMUSP00000141695
Ensembl peptide - ENSMUSP00000085298
Ensembl peptide - ENSMUSP00000103679
Ensembl peptide - ENSMUSP00000128277
NCBI entrez gene - 16182     See in Manteia.
MGI - MGI:105383
RefSeq - XM_006495734
RefSeq - NM_001161842
RefSeq - NM_001161843
RefSeq - NM_008365
RefSeq - XM_006495727
RefSeq - XM_006495728
RefSeq - XM_006495729
RefSeq - XM_006495730
RefSeq - XM_006495732
RefSeq Peptide - NP_001155314
RefSeq Peptide - NP_001155315
RefSeq Peptide - NP_032391
swissprot - A0A0A6YWA3
swissprot - Q61098
swissprot - Q8C257
Ensembl - ENSMUSG00000026070
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL18R1ENSGALG00000040621Gallus gallus
 IL18R1ENSG00000115604Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9ERS6 / Il1rapl2 / X-linked interleukin-1 receptor accessory protein-like 2 / Q9NP60* / interleukin 1 receptor accessory protein like 2*ENSMUSG0000005920327
Il1rapl1 / interleukin 1 receptor accessory protein like 1 / Q9NZN1*ENSMUSG0000005237226
Il1rl1 / P14719 / Interleukin-1 receptor-like 1 / Q01638*ENSMUSG0000002606926
Il1r1 / P13504 / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form / P14778* / interleukin 1 receptor type 1*ENSMUSG0000002607225
Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*ENSMUSG0000002251423
Q9Z2B1 / Il18rap / Interleukin-18 receptor accessory protein / O95256*ENSMUSG0000002606823
Il1rl2 / Q9ERS7 / Mus musculus interleukin 1 receptor-like 2 (Il1rl2), transcript variant 2, mRNA. / Q9HB29* / interleukin 1 receptor like 2*ENSMUSG0000007094221
Il1r2 / P27931 / Interleukin-1 receptor type 2 Interleukin-1 receptor type 2, membrane form Interleukin-1 receptor type 2, soluble form / P27930* / interleukin 1 receptor type 2*ENSMUSG0000002607312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030101 natural killer cell activation IMP
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0035655 interleukin-18-mediated signaling pathway IMP
 biological_processGO:0045063 T-helper 1 cell differentiation IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042008 interleukin-18 receptor activity IMP


Pathways (from Reactome)
Pathway description
Interleukin-18 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Lims1tm2Ref/Lims1tm2Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Lims1tm2Ref/Lims1tm2Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Lims1tm2Ref/Lims1tm2Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039217 Il18 / P70380 / Interleukin-18 / Q14116*  / complex / reaction
 ENSMUSG00000026068 Q9Z2B1 / Il18rap / Interleukin-18 receptor accessory protein / O95256*  / complex / reaction






 

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