ENSMUSG00000026072


Mus musculus

Features
Gene ID: ENSMUSG00000026072
  
Biological name :Il1r1
  
Synonyms : Il1r1 / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form / P13504
  
Possible biological names infered from orthology : interleukin 1 receptor type 1 / P14778
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 40225080
Gene end: 40317257
  
Corresponding Affymetrix probe sets: 10345762 (MoGene1.0st)   1448950_at (Mouse Genome 430 2.0 Array)   1459777_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027241
Ensembl peptide - ENSMUSP00000110443
NCBI entrez gene - 16177     See in Manteia.
MGI - MGI:96545
RefSeq - XM_017317613
RefSeq - NM_001123382
RefSeq - NM_008362
RefSeq - XM_006495721
RefSeq - XM_006495722
RefSeq - XM_006495723
RefSeq - XM_011238436
RefSeq - XM_017317595
RefSeq - XM_006495713
RefSeq - XM_006495714
RefSeq - XM_006495715
RefSeq - XM_006495717
RefSeq - XM_006495719
RefSeq - XM_006495720
RefSeq Peptide - NP_032388
RefSeq Peptide - NP_001116854
swissprot - P13504
swissprot - Q32MH0
swissprot - Q8C833
Ensembl - ENSMUSG00000026072
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01054965.1ENSDARG00000090844Danio rerio
 CU855885.1ENSDARG00000101527Danio rerio
 ENSGALG00000030526Gallus gallus
 IL1R1ENSGALG00000043044Gallus gallus
 IL1R1ENSG00000115594Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il1rl2 / Q9ERS7 / Mus musculus interleukin 1 receptor-like 2 (Il1rl2), transcript variant 2, mRNA. / Q9HB29* / interleukin 1 receptor like 2*ENSMUSG0000007094236
Il1rl1 / P14719 / Interleukin-1 receptor-like 1 / Q01638*ENSMUSG0000002606927
Il1rapl1 / interleukin 1 receptor accessory protein like 1 / Q9NZN1*ENSMUSG0000005237226
Q9ERS6 / Il1rapl2 / X-linked interleukin-1 receptor accessory protein-like 2 / Q9NP60* / interleukin 1 receptor accessory protein like 2*ENSMUSG0000005920326
Il18r1 / Q61098 / Interleukin-18 receptor 1 / Q13478*ENSMUSG0000002607023
Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*ENSMUSG0000002251422
Q9Z2B1 / Il18rap / Interleukin-18 receptor accessory protein / O95256*ENSMUSG0000002606820
Il1r2 / P27931 / Interleukin-1 receptor type 2 Interleukin-1 receptor type 2, membrane form Interleukin-1 receptor type 2, soluble form / P27930* / interleukin 1 receptor type 2*ENSMUSG0000002607317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR003599  Immunoglobulin subtype
 IPR004074  Interleukin-1 receptor type I/II
 IPR004076  Interleukin-1 receptor type 1
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR015621  Interleukin-1 receptor family
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:2000391 positive regulation of neutrophil extravasation IMP
 biological_processGO:2000661 positive regulation of interleukin-1-mediated signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004871 obsolete signal transducer activity IDA
 molecular_functionGO:0004908 interleukin-1 receptor activity IEA
 molecular_functionGO:0004909 interleukin-1, type I, activating receptor activity IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019966 interleukin-1 binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcrAND)53Hed/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcrAND)53Hed/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spictm1Kmm/Spictm1Kmm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: S1pr1tm1Jch/S1pr1tm1Jch,Tg(GFAP-cre)25Mes/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A * C3H/HeH

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

 MP:0001337 dry eyes "absence of natural or normal moisture in the eye" [J:53284]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

 MP:0001346 abnormal lacrimal gland morphology "malformation of the glands that secrete tears" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: S1pr1tm1Jch/S1pr1tm1Jch,Tg(GFAP-cre)25Mes/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Cdh1tm2Kem/Cdh1tm2Kem,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Il1r1tm1.1Rbl/Il1r1tm1.1Rbl
Genetic Background: B6.129(Cg)-Il1r1tm1.1Rbl

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd3etm1.1Geno/Cd3etm1.1Geno,Tg(TcrAND)53Hed/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcn2ap/Hcn2+
Genetic Background: DW/Pas-Hcn2ap

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129-Il1r1tm1Imx Apoetm1Unc

 MP:0002865 increased growth rate "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129-Il1r1tm1Imx Apoetm1Unc

 MP:0003053 delayed tooth eruption "postponed onset of the growth of the teeth out of the gums" [pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Hcn2ap/Hcn2+
Genetic Background: DW/Pas-Hcn2ap

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9tm1Mrc
Genetic Background: B6.129S7-Hoxa9tm1Mrc

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0003829 impaired febrile response "reduced or absent febrile response to exogenous or endogenous pyrogens" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:70534]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003959 abnormal lean body mass "aberrant fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1.1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0004702 increased circulating insulin-like growth factor I level "increased blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc8a1tm1Sjc/Slc8a1tm1Sjc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004822 decreased susceptibility to experimental autoimmune uveoretinitis "reduced likelihood that an organism will develop disease symptoms similar to human sight-threatening inflammatory eye diseases upon induction by peripheral immunization with one of several uveitogenic retinal proteins (or with peptides derived from them), or by the adoptive transfer of lymphocytes specific to these antigens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Nlrp3tm1Hhf/Nlrp3+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005190 osteomyelitis "bone inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129-Il1r1tm1Imx Apoetm1Unc

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0005460 abnormal leukopoiesis "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129-Il1r1tm1Imx Apoetm1Unc

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

 MP:0006087 increased body mass index "greater than normal average of a measure of weight for height" [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0006194 keratoconjunctivitis "inflammation of the conjunctiva and cornea" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129-Il1r1tm1Imx Apoetm1Unc

 MP:0008635 increased circulating interleukin-18 level "increase in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0008636 decreased circulating interleukin-18 level "reduction in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Mefvtm5.1(MEFV)Chae/Mefvtm5.1(MEFV)Chae
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1.1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008838 decreased transforming growth factor level "reduced concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0009286 increased abdominal fat pad weight "greater than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0009292 increased inguinal fat pad weight 
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0009298 increased mesenteric fat pad weight 
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0009304 increased retroperitoneal fat pad weight 
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0010214 abnormal circulating serum amyloid protein level "deviation from the normal blood levels of an acute-phase reaction protein that is a precursor to amyloid A protein; it is present in very high levels during acute inflammatory episodes, and is present in low concentrations in normal sera, but is found at higher concentrations in sera of older persons and in patients with amyloidosis" [MESH:D12.776.049.790, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: B6.129S7-Il1r1tm1Imx/J

 MP:0010762 abnormal microglial cell activation "any anomaly in change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh1tm2Kem/Cdh1tm2Kem,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Trp53tm1Brn/Trp53tm1Brn,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011020 abnormal circadian temperature homeostasis "any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0012164 abnormal conjunctiva goblet cell morphology "any structural anomaly of a goblet cell that is part of the epithelium of the conjunctiva, and is the source of tear mucins which are secreted from it" [MGI:csmith]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

 MP:0013251 dental pulp necrosis "morphological changes resulting from pathological death of dental pulp tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013754 abnormal ocular surface morphology "any structural anomaly of the integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms" [http://www.medscape.org/viewarticle/702141, ISBN:978-1-4665-6559-3, ISBN:978-3-318-01404-4]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025139 Q9QZ06 / Tollip / toll interacting protein / Q9H0E2*  / complex / reaction
 ENSMUSG00000022514 Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*  / complex / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / complex / reaction
 ENSMUSG00000027399 Il1a / P01582 / Interleukin-1 alpha / P01583*  / reaction / complex
 ENSMUSG00000027398 Il1b / P10749 / Interleukin-1 beta / P01584*  / complex / reaction
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / reaction / complex
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex / reaction
 ENSMUSG00000026981 Il1rn / P25085 / Interleukin-1 receptor antagonist protein / P18510* / interleukin 1 receptor antagonist*  / complex / reaction






 

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