ENSMUSG00000025139


Mus musculus

Features
Gene ID: ENSMUSG00000025139
  
Biological name :Tollip
  
Synonyms : Q9QZ06 / toll interacting protein / Tollip
  
Possible biological names infered from orthology : Q9H0E2
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 141874813
Gene end: 141918507
  
Corresponding Affymetrix probe sets: 10569265 (MoGene1.0st)   1423047_at (Mouse Genome 430 2.0 Array)   1423048_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118336
Ensembl peptide - ENSMUSP00000001950
Ensembl peptide - ENSMUSP00000051485
Ensembl peptide - ENSMUSP00000117938
NCBI entrez gene - 54473     See in Manteia.
MGI - MGI:1891808
RefSeq - NM_023764
RefSeq - XM_006508631
RefSeq - NM_001347562
RefSeq Peptide - NP_001334491
RefSeq Peptide - NP_076253
swissprot - A9JEI5
swissprot - Q8C5G6
swissprot - Q9QZ06
swissprot - F7AT44
Ensembl - ENSMUSG00000025139
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tollipENSDARG00000098486Danio rerio
 TOLLIPENSGALG00000006697Gallus gallus
 Q9H0E2ENSG00000078902Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR003892  Ubiquitin system component Cue
 IPR009060  UBA-like superfamily
 IPR035892  C2 domain superfamily
 IPR037301  Toll-interacting protein, C2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0033235 positive regulation of protein sumoylation IEA
 biological_processGO:0036010 protein localization to endosome IEA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005150 interleukin-1, type I receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0032183 SUMO binding IEA
 molecular_functionGO:0035325 Toll-like receptor binding IEA
 molecular_functionGO:0043130 ubiquitin binding IBA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027399 Il1a / P01582 / Interleukin-1 alpha / P01583*  / complex / reaction
 ENSMUSG00000027398 Il1b / P10749 / Interleukin-1 beta / P01584*  / complex / reaction
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / reaction / complex
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000026072 Il1r1 / P13504 / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form / P14778* / interleukin 1 receptor type 1*  / reaction / complex
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex / reaction
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / complex / reaction
 ENSMUSG00000022514 Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*  / reaction / complex






 

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