ENSMUSG00000032508


Mus musculus

Features
Gene ID: ENSMUSG00000032508
  
Biological name :Myd88
  
Synonyms : Myd88 / myeloid differentiation primary response gene 88 / P22366
  
Possible biological names infered from orthology : myeloid differentiation primary response 88 / Q99836
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F3
Gene start: 119335934
Gene end: 119341411
  
Corresponding Affymetrix probe sets: 10597648 (MoGene1.0st)   1419272_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035092
Ensembl peptide - ENSMUSP00000115746
NCBI entrez gene - 17874     See in Manteia.
MGI - MGI:108005
RefSeq - NM_010851
RefSeq Peptide - NP_034981
swissprot - F6SPW1
swissprot - P22366
swissprot - Q3U7M4
Ensembl - ENSMUSG00000032508
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myd88ENSDARG00000010169Danio rerio
 MYD88ENSGALG00000005947Gallus gallus
 MYD88ENSG00000172936Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000488  Death domain
 IPR011029  Death-like domain superfamily
 IPR017281  Myeloid differentiation primary response protein MyD88
 IPR034249  MyD88, death domain
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002238 response to molecule of fungal origin IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IMP
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IMP
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway TAS
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0008063 Toll signaling pathway IEA
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0009682 induced systemic resistance IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016064 immunoglobulin mediated immune response IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IMP
 biological_processGO:0032481 positive regulation of type I interferon production ISO
 biological_processGO:0032494 response to peptidoglycan IMP
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032675 regulation of interleukin-6 production IMP
 biological_processGO:0032680 regulation of tumor necrosis factor production IMP
 biological_processGO:0032740 positive regulation of interleukin-17 production IMP
 biological_processGO:0032747 positive regulation of interleukin-23 production IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0044130 negative regulation of growth of symbiont in host IMP
 biological_processGO:0045080 positive regulation of chemokine biosynthetic process IGI
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045351 type I interferon biosynthetic process IMP
 biological_processGO:0046330 positive regulation of JNK cascade IMP
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050671 positive regulation of lymphocyte proliferation IMP
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0060337 type I interferon signaling pathway ISO
 biological_processGO:0070555 response to interleukin-1 ISO
 biological_processGO:0070935 3"-UTR-mediated mRNA stabilization ISO
 biological_processGO:0090557 establishment of endothelial intestinal barrier IMP
 biological_processGO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus IMP
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response IMP
 biological_processGO:1902622 regulation of neutrophil migration IMP
 biological_processGO:2000338 regulation of chemokine (C-X-C motif) ligand 1 production IMP
 biological_processGO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0014069 postsynaptic density IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005121 Toll binding IEA
 molecular_functionGO:0005149 interleukin-1 receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0035325 Toll-like receptor binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043621 protein self-association ISO
 molecular_functionGO:0070976 TIR domain binding ISO


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
RIP-mediated NFkB activation via ZBP1
p75NTR recruits signalling complexes
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tph2tm1Pasq/Tph2tm1Pasq
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or B6.129P2-Tph2tm1Pasq

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc17a6tm1Lex/Slc17a6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Myd88poc/Myd88poc
Genetic Background: C57BL/6-Myd88poc

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2tm1Hko,Bmi1tm1Brn/Bmi1tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a6tm1Lex/Slc17a6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a6tm1Lex/Slc17a6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002334 abnormal airway responsiveness "anomalous response in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: Not Specified

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Clec7atm1Yiw/Clec7atm1Yiw,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * BALB/cA * C57BL/6J

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: B6.Cg-Myd88tm1Defr Tg(Itgax-cre)1-1Reiz

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myd88poc/Myd88poc
Genetic Background: C57BL/6-Myd88poc

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr9M1Btlr/Tlr9M1Btlr
Genetic Background: involves: C57BL/6

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

Allelic Composition: Myd88poc/Myd88poc
Genetic Background: C57BL/6-Myd88poc

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tlr6int/Tlr6int
Genetic Background: C57BL/6-Tlr6int

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tlr6int/Tlr6int
Genetic Background: C57BL/6-Tlr6int

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr6int/Tlr6int
Genetic Background: C57BL/6-Tlr6int

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr9M1Btlr/Tlr9M1Btlr
Genetic Background: involves: C57BL/6

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: Not Specified

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

Allelic Composition: Myd88lkd/Myd88lkd
Genetic Background: C57BL/6-Myd88lkd

Allelic Composition: Myd88poc/Myd88poc
Genetic Background: C57BL/6-Myd88poc

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tph2tm1Pasq/Tph2tm1Pasq
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or B6.129P2-Tph2tm1Pasq

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: Not Specified

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Clec7atm1Yiw/Clec7atm1Yiw,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * BALB/cA * C57BL/6J

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Tg(Ccr2-GFP)8Pam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003293 rectal hemorrhage "bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Pglyrp1tm1Rdz/Pglyrp1tm1Rdz,Pglyrp2tm1Rdz/Pglyrp2tm1Rdz
Genetic Background: C.129S-Pglyrp1tm1Rdz Pglyrp2tm1Rdz

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0004242 abnormal plasmacytoid dendritic cell morphology "any structural anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:10449155, PMID:15596797]
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Allelic Composition: Cadps2tm1Bros/Cadps2tm1Bros
Genetic Background: Not Specified

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Tanktm1Aki/Tanktm1Aki
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1Lex/Slc17a6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gli2tm3.1Blnw/Gli2tm3.1Blnw,Ptch1tm1Mps/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Ticam1tm1Aki/Ticam1+
Genetic Background: B6.129P2-Myd88tm1Aki Ticam1tm1Aki

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129-Myd88tm1Aki Ifnar1tm1Agt

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Myd88tm1Aki/Myd88+
Genetic Background: B6.129-Myd88tm1Aki Ifnar1tm1Agt

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: Not Specified

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz
Genetic Background: B6.129P2-Myd88tm1Hlz

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dsprul/Dsp+
Genetic Background: RB156Bnr/Ei-Dsprul/GrsrJ

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Dsprul/Dsp+
Genetic Background: RB156Bnr/Ei-Dsprul/GrsrJ

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Tph2tm1Pasq/Tph2tm1Pasq
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or B6.129P2-Tph2tm1Pasq

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0006071 abnormal retinal progenitor morphology "anomoly in the proliferation or differentiation of the cells that give rise to the various cells of the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0006334 abnormal susceptibility to hearing loss "anomaly in the sensitivity to loss of hearing related to age or environmental factors " [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0008042 abnormal NK T cell physiology "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: Not Specified

 MP:0008051 abnormal memory T cell physiology "any functional anomaly of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Dsprul/Dsp+
Genetic Background: RB156Bnr/Ei-Dsprul/GrsrJ

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: B6.Cg-Myd88tm1Defr Tg(Itgax-cre)1-1Reiz

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: B6.Cg-Myd88tm1Defr Tg(Itgax-cre)1-1Reiz

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Slc17a6tm1Lex/Slc17a6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: B6.Cg-Myd88tm1Defr Tg(Itgax-cre)1-1Reiz

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: B6.Cg-Myd88tm1Defr Tg(Itgax-cre)1-1Reiz

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Traddtm1.1Mpa/Traddtm1.1Mpa
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz
Genetic Background: B6.129P2-Myd88tm1Hlz

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129-Myd88tm1Aki

Allelic Composition: Myd88M4Btlr/Myd88M4Btlr
Genetic Background: C57BL/6J-Myd88M4Btlr

Allelic Composition: Myd88M4Btlr/Myd88+
Genetic Background: C57BL/6J-Myd88M4Btlr

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

Allelic Composition: Ifna6tm1Aki/Ifna6+,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008594 decreased circulating interleukin-10 level "reduction in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz
Genetic Background: B6.129P2-Myd88tm1Hlz

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: B6.Cg-Myd88tm1Defr Tg(Itgax-cre)1-1Reiz

Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz
Genetic Background: B6.129P2-Myd88tm1Hlz

 MP:0008648 decreased circulating interleukin-12b level "reduction in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: B6.Cg-Myd88tm1Defr Tg(Itgax-cre)1-1Reiz

Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz
Genetic Background: B6.129P2-Myd88tm1Hlz

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz
Genetic Background: B6.129P2-Myd88tm1Hlz

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0008670 decreased interleukin-12b secretion "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz
Genetic Background: B6.129P2-Myd88tm1Hlz

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129-Myd88tm1Aki

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz
Genetic Background: B6.129P2-Myd88tm1Hlz

Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0008882 abnormal enterocyte physiology "any functional anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008897 decreased IgG2c level "less than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: B6.Cg-Myd88tm1Defr Tg(Itgax-cre)1-1Reiz

 MP:0008906 abnormal parametrial fat pad morphology "any structural anomaly of the encapsulated adipose tissue associated with the extension of the subserous coat of the uterus laterally between the layers of the broad ligament" [ISBN-13:978-0-7020-2972-1]
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Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Myd88tm1Aki/Myd88tm1Aki,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Myd88tm1Aki Tg(Vil1-cre)997Gum

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

 MP:0010222 abnormal T-helper 17 cell physiology "any functional anomaly of a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Dsprul/Dsp+
Genetic Background: RB156Bnr/Ei-Dsprul/GrsrJ

 MP:0010266 decreased liver tumor incidence "less than the expected number of neoplams in the liver, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0010377 abnormal gut flora balance "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

 MP:0010750 increased susceptibility to parasitic infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli2tm3.1Blnw/Gli2tm3.1Blnw,Ptch1tm1Mps/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Ticam1tm1Aki/Ticam1+
Genetic Background: B6.129P2-Myd88tm1Aki Ticam1tm1Aki

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129-Myd88tm1Aki Ifnar1tm1Agt

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: Not Specified

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: B6.Cg-Myd88tm1Defr Tg(Itgax-cre)1-1Reiz

Allelic Composition: Myd88tm1Defr/Myd88tm1Defr,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arih2tm1Mak/Arih2tm1Mak
Genetic Background: B6.129P2-Arih2tm1Mak

 MP:0011077 decreased macrophage nitric oxide production "reduced production of macrophage-derived nitric oxide due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki Ticam1tm1Aki

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Ticam1tm1Aki/Ticam1+
Genetic Background: B6.129P2-Myd88tm1Aki Ticam1tm1Aki

 MP:0011079 decreased macrophage cytokine production "reduced production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki Ticam1tm1Aki

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Ticam1tm1Aki/Ticam1+
Genetic Background: B6.129P2-Myd88tm1Aki Ticam1tm1Aki

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Myd88tm1Jcbr/Myd88tm1Jcbr,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln

 MP:0013486 decreased Paneth cell number "fewer than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Myd88tm1Aki/Myd88tm1Aki,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Myd88tm1Aki Tg(Vil1-cre)997Gum

 MP:0020186 altered susceptibility to bacterial infection "a change in the likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [GOC:NV]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129-Myd88tm1Aki

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000120 Ngfr / nerve growth factor receptor / P08138*  / complex
 ENSMUSG00000025139 Q9QZ06 / Tollip / toll interacting protein / Q9H0E2*  / reaction / complex
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex / reaction
 ENSMUSG00000025498 Irf7 / P70434 / interferon regulatory factor 7 / Q92985*  / reaction / complex
 ENSMUSG00000026072 Il1r1 / P13504 / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form / P14778* / interleukin 1 receptor type 1*  / reaction / complex
 ENSMUSG00000022514 Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*  / complex / reaction
 ENSMUSG00000024810 Il33 / Q8BVZ5 / Interleukin-33 Interleukin-33(102-266) Interleukin-33(109-266) / O95760* / interleukin 33*  / complex
 ENSMUSG00000040522 Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*  / reaction / complex
 ENSMUSG00000045322 Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*  / complex / reaction
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / reaction / complex
 ENSMUSG00000060477 Irak2 / Q8CFA1 / Interleukin-1 receptor-associated kinase-like 2 / O43187* / interleukin 1 receptor associated kinase 2*  / reaction / complex
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / reaction / complex
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / complex / reaction
 ENSMUSG00000044583 Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*  / complex / reaction
 ENSMUSG00000027770 Dhx36 / Q8VHK9 / ATP-dependent RNA helicase DHX36 / Q9H2U1* / DEAH-box helicase 36*  / complex / reaction
 ENSMUSG00000027398 Il1b / P10749 / Interleukin-1 beta / P01584*  / complex / reaction
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / complex
 ENSMUSG00000027399 Il1a / P01582 / Interleukin-1 alpha / P01583*  / complex / reaction
 ENSMUSG00000026069 Il1rl1 / P14719 / Interleukin-1 receptor-like 1 / Q01638*  / complex






 

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