ENSMUSG00000024810


Mus musculus

Features
Gene ID: ENSMUSG00000024810
  
Biological name :Il33
  
Synonyms : Il33 / Interleukin-33 Interleukin-33(102-266) Interleukin-33(109-266) / Q8BVZ5
  
Possible biological names infered from orthology : interleukin 33 / O95760
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C1
Gene start: 29925114
Gene end: 29960718
  
Corresponding Affymetrix probe sets: 10462442 (MoGene1.0st)   1416200_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113829
Ensembl peptide - ENSMUSP00000135324
Ensembl peptide - ENSMUSP00000135854
Ensembl peptide - ENSMUSP00000025724
Ensembl peptide - ENSMUSP00000122319
NCBI entrez gene - 77125     See in Manteia.
MGI - MGI:1924375
RefSeq - XM_011247399
RefSeq - NM_001164724
RefSeq - NM_133775
RefSeq - XM_006527463
RefSeq Peptide - NP_001158196
RefSeq Peptide - NP_598536
swissprot - D3Z6T7
swissprot - H3BLN5
swissprot - H3BKB5
swissprot - Q8BVZ5
Ensembl - ENSMUSG00000024810
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL33ENSG00000137033Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026145  Interleukin-33


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002281 macrophage activation involved in immune response IDA
 biological_processGO:0002282 microglial cell activation involved in immune response IDA
 biological_processGO:0002686 negative regulation of leukocyte migration IGI
 biological_processGO:0002826 negative regulation of T-helper 1 type immune response IGI
 biological_processGO:0002830 positive regulation of type 2 immune response IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
 biological_processGO:0032689 negative regulation of interferon-gamma production IGI
 biological_processGO:0032736 positive regulation of interleukin-13 production IGI
 biological_processGO:0032753 positive regulation of interleukin-4 production IGI
 biological_processGO:0032754 positive regulation of interleukin-5 production IGI
 biological_processGO:0032755 positive regulation of interleukin-6 production IGI
 biological_processGO:0043032 positive regulation of macrophage activation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050729 positive regulation of inflammatory response IDA
 biological_processGO:0051024 positive regulation of immunoglobulin secretion IGI
 biological_processGO:0051025 negative regulation of immunoglobulin secretion IGI
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0061518 microglial cell proliferation IDA
 biological_processGO:0090197 positive regulation of chemokine secretion IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005125 cytokine activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Ub-specific processing proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-33 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001819 abnormal immune cell physiology "abnormal function of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: Not Specified

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tlr9M7Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9M7Btlr

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr9M7Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9M7Btlr

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr9M7Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9M7Btlr

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003507 abnormal ovary physiology "anomaly or loss either the production of female germ cells or the endocrine cells for the production of estrogen and progesterone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: Not Specified

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

Allelic Composition: Il33tm1Amgn/Il33tm1Amgn
Genetic Background: B6.129-Il33tm1Amgn

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr9M7Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9M7Btlr

 MP:0008655 decreased interleukin-1 alpha secretion "reduction in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
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Allelic Composition: Tlr9M7Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9M7Btlr

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Tlr9M7Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9M7Btlr

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tlr9M7Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9M7Btlr

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr9M7Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9M7Btlr

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0009648 abnormal superovulation "impaired ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr9M7Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9M7Btlr

 MP:0010862 decreased respiratory mucosa goblet cell number "reduced number of the cells of the respiratory epithelial lining that produce and secrete mucins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cfl2tm1.1Itl/Cfl2tm1.1Itl
Genetic Background: involves: C57BL/6J * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022514 Il1rap / Q61730 / Interleukin-1 receptor accessory protein / Q9NPH3*  / reaction / complex
 ENSMUSG00000053483 Usp21 / ubiquitin specific peptidase 21 / Q9UK80*  / complex
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / complex
 ENSMUSG00000026069 Il1rl1 / P14719 / Interleukin-1 receptor-like 1 / Q01638*  / reaction / complex
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / complex
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex






 

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