ENSMUSG00000053483


Mus musculus

Features
Gene ID: ENSMUSG00000053483
  
Biological name :Usp21
  
Synonyms : ubiquitin specific peptidase 21 / Usp21
  
Possible biological names infered from orthology : Q9UK80
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 171281945
Gene end: 171287991
  
Corresponding Affymetrix probe sets: 10360105 (MoGene1.0st)   1454034_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106936
Ensembl peptide - ENSMUSP00000133362
Ensembl peptide - ENSMUSP00000120161
Ensembl peptide - ENSMUSP00000106938
Ensembl peptide - ENSMUSP00000064002
NCBI entrez gene - 30941     See in Manteia.
MGI - MGI:1353665
RefSeq - NM_013919
RefSeq Peptide - NP_038947
swissprot - E9PUE2
swissprot - G3UWN7
swissprot - D6RJJ7
swissprot - A0A0R4J1F5
Ensembl - ENSMUSG00000053483
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp21ENSDARG00000094280Danio rerio
 USP21ENSG00000143258Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp2 / O88623 / ubiquitin specific peptidase 2 / O75604*ENSMUSG0000003201040
Usp8 / Q80U87 / ubiquitin specific peptidase 8 / P40818*ENSMUSG0000002736328
Usp33 / Q8R5K2 / ubiquitin specific peptidase 33 / Q8TEY7*ENSMUSG0000002543723
Usp20 / Q8C6M1 / ubiquitin specific peptidase 20 / Q9Y2K6*ENSMUSG0000002685423
Usp45 / Q8K387 / ubiquitin specific petidase 45 / Q70EL2* / ubiquitin specific peptidase 45*ENSMUSG0000004045521
Usp16 / Q99LG0 / ubiquitin specific peptidase 16 / Q9Y5T5*ENSMUSG0000002561621
Usp50 / Q6P8X6 / ubiquitin specific peptidase 50 / Q70EL3*ENSMUSG0000002736420


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0031175 neuron projection development IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0019784 NEDD8-specific protease activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Khdrbs1tm1Rchd/Khdrbs1tm1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Khdrbs1tm1Rchd/Khdrbs1tm1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0002399 abnormal pluripotent precursor cell morphology/development "anomalous structure or fomation of the cells that give rise to most types of cells necessary for fetal development" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Khdrbs1tm1Rchd/Khdrbs1tm1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Khdrbs1tm1Rchd/Khdrbs1tm1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Khdrbs1tm1Rchd/Khdrbs1tm1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0008573 increased circulating interferon-alpha level "increase in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Khdrbs1tm1Rchd/Khdrbs1tm1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008575 increased circulating interferon-beta level "increase in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Khdrbs1tm1Rchd/Khdrbs1tm1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Khdrbs1tm1Rchd/Khdrbs1tm1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Khdrbs1tm1Rchd/Khdrbs1tm1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Khdrbs1tm1Rchd/Khdrbs1tm1Rchd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010088 decreased circulating fructosamine level "decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / complex
 ENSMUSG00000024810 Il33 / Q8BVZ5 / Interleukin-33 Interleukin-33(102-266) Interleukin-33(109-266) / O95760* / interleukin 33*  / complex
 ENSMUSG00000040296 Ddx58 / Q6Q899 / Probable ATP-dependent RNA helicase DDX58 / O95786* / DExD/H-box helicase 58*  / complex
 ENSMUSG00000015619 Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*  / complex






 

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