ENSDARG00000094280


Danio rerio

Features
Gene ID: ENSDARG00000094280
  
Biological name :usp21
  
Synonyms : ubiquitin specific peptidase 21 / usp21
  
Possible biological names infered from orthology : Q9UK80
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 20687340
Gene end: 20701863
  
Corresponding Affymetrix probe sets: Dr.18585.1.A1_at (Zebrafish Array)   XM_686911_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000155781
Ensembl peptide - ENSDARP00000122828
NCBI entrez gene - 563546     See in Manteia.
RefSeq - XM_005162129
RefSeq - XM_686911
swissprot - E9QFQ5
ZFIN ID - ZDB-GENE-100210-3
Ensembl - ENSDARG00000094280
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 USP21ENSG00000143258Homo sapiens
 Usp21ENSMUSG00000053483Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
usp2a / ubiquitin specific peptidase 2a / USP2* / O75604* / O88623* / ubiquitin specific peptidase 2*ENSDARG0000002010740
usp2b / ubiquitin specific peptidase 2b / USP2* / O75604* / O88623* / ubiquitin specific peptidase 2*ENSDARG0000007412040
usp8 / ubiquitin specific peptidase 8 / P40818* / Q80U87*ENSDARG0000006371930
usp33 / A5PMR2 / ubiquitin specific peptidase 33 / Q8R5K2* / Q8TEY7*ENSDARG0000001616329
usp45 / ubiquitin specific peptidase 45 / Q70EL2* / Q8K387* / ubiquitin specific petidase 45*ENSDARG0000007501328
usp20 / A5PN09 / ubiquitin specific peptidase 20 / Q9Y2K6*ENSDARG0000002750128
usp16 / A8HAL1 / ubiquitin specific peptidase 16 / Q99LG0* / Q9Y5T5*ENSDARG0000006063327


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0021551 central nervous system morphogenesis IMP
 biological_processGO:1904888 cranial skeletal system development IMP
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0001094 whole organism whole organism necrotic , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head immature , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage morphology , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage malformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000016526 gata3 / Q91428 / GATA binding protein 3 / P23771* / P23772* / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA.*  / complex






 

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