ENSDARG00000063719


Danio rerio

Features
Gene ID: ENSDARG00000063719
  
Biological name :usp8
  
Synonyms : ubiquitin specific peptidase 8 / usp8
  
Possible biological names infered from orthology : P40818 / Q80U87
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 95770
Gene end: 107697
  
Corresponding Affymetrix probe sets: Dr.1205.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000126067
NCBI entrez gene - 565434     See in Manteia.
RefSeq - XM_009293354
RefSeq - XM_009293353
RefSeq - XM_021467716
RefSeq - XM_021467717
swissprot - I3IT16
ZFIN ID - ZDB-GENE-030131-1949
Ensembl - ENSDARG00000063719
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 USP8ENSGALG00000005894Gallus gallus
 USP8ENSG00000138592Homo sapiens
 Usp8ENSMUSG00000027363Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
usp2b / ubiquitin specific peptidase 2b / USP2* / O75604* / O88623* / ubiquitin specific peptidase 2*ENSDARG0000007412015
usp2a / ubiquitin specific peptidase 2a / USP2* / O75604* / O88623* / ubiquitin specific peptidase 2*ENSDARG0000002010714
usp45 / ubiquitin specific peptidase 45 / Q70EL2* / Q8K387* / ubiquitin specific petidase 45*ENSDARG0000007501312
usp20 / A5PN09 / ubiquitin specific peptidase 20 / Q9Y2K6*ENSDARG0000002750112
usp33 / A5PMR2 / ubiquitin specific peptidase 33 / Q8R5K2* / Q8TEY7*ENSDARG0000001616312
usp16 / A8HAL1 / ubiquitin specific peptidase 16 / Q99LG0* / Q9Y5T5*ENSDARG0000006063311
usp21 / ubiquitin specific peptidase 21 / Q9UK80*ENSDARG0000009428011


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001763  Rhodanese-like domain
 IPR015063  USP8 dimerisation domain
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Downregulation of ERBB2:ERBB3 signaling
Regulation of FZD by ubiquitination
Ub-specific processing proteases
Negative regulation of MET activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000155 somite somite fused with somite , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001115 trunk trunk necrotic , abnormal
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 ZFA:0001117 post-vent region post-vent region curled , abnormal
post-vent region curved , abnormal
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 ZFA:0009052 motor neuron motor neuron axon branched , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011462 otub1b / OTU deubiquitinase, ubiquitin aldehyde binding 1b / OTUB1* / Q7TQI3* / Q96FW1* / Ubiquitin thioesterase OTUB1 * / OTU deubiquitinase, ubiquitin aldehyde binding 1*  / complex
 ENSDARG00000005318 stam2 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / O88811* / signal transducing adaptor molecule 2*  / complex
 ENSDARG00000016867 rnf128a / ring finger protein 128a / Q8N7C7* / Q8TEB7* / Q8WVZ7* / Q9D304* / RNF148* / G3X9R7* / Q14B02* / RNF128* / RNF133* / ring finger protein 148* / ring finger protein 133* / E3 ubiqu...  / complex
 ENSDARG00000055536 otub1a / OTU deubiquitinase, ubiquitin aldehyde binding 1a / OTUB1* / Q7TQI3* / Q96FW1* / Ubiquitin thioesterase OTUB1 * / OTU deubiquitinase, ubiquitin aldehyde binding 1*  / complex
 ENSDARG00000075625 lrig1 / leucine-rich repeats and immunoglobulin-like domains 1 / P70193* / Q96JA1* / Leucine-rich repeats and immunoglobulin-like domains protein 1 *  / reaction
 ENSDARG00000020960 hgs / hepatocyte growth factor-regulated tyrosine kinase substrate / O14964* / hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 *  / complex
 ENSDARG00000070903 met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction






 

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