ENSDARG00000070903


Danio rerio

Features
Gene ID: ENSDARG00000070903
  
Biological name :met
  
Synonyms : met / MET proto-oncogene, receptor tyrosine kinase
  
Possible biological names infered from orthology : P08581
  
Species: Danio rerio
  
Chr. number: 25
Strand: 1
Band:
Gene start: 18583877
Gene end: 18679071
  
Corresponding Affymetrix probe sets: Dr.18290.1.A1_at (Zebrafish Array)   NM_001007124_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000123904
Ensembl peptide - ENSDARP00000152967
NCBI entrez gene - 100150664     See in Manteia.
RefSeq - NM_001007124
RefSeq Peptide - NP_001007125
swissprot - F1QLR7
ZFIN ID - ZDB-GENE-041014-1
Ensembl - ENSDARG00000070903
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 METENSGALG00000036883Gallus gallus
 METENSG00000105976Homo sapiens
 MetENSMUSG00000009376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mst1rb / macrophage stimulating 1 receptor b / MST1R* / Q04912* / Q62190* / macrophage stimulating 1 receptor* / macrophage stimulating 1 receptor (c-met-related tyrosine kinase)*ENSDARG0000000487138
mst1ra / macrophage stimulating 1 receptor a / MST1R* / Q04912* / Q62190* / macrophage stimulating 1 receptor* / macrophage stimulating 1 receptor (c-met-related tyrosine kinase)*ENSDARG0000006023535
mertka / c-mer proto-oncogene tyrosine kinase a / MERTK* / Q12866* / Q60805* / Tyrosine-protein kinase Mer * / MER proto-oncogene, tyrosine kinase*ENSDARG0000007469514
tyro3 / TYRO3 protein tyrosine kinase / P55144* / Q06418* / TYRO3 protein tyrosine kinase 3*ENSDARG0000000535613
si:ch73-40a2.1ENSDARG0000010552113
tie1 / tyrosine kinase with immunoglobulin-like and EGF-like domains 1 / P35590* / Q06806*ENSDARG0000000410512
tek / TEK tyrosine kinase, endothelial / Q02763* / TEK receptor tyrosine kinase*ENSDARG0000002866312
AXL / AXL receptor tyrosine kinase / P30530*ENSDARG0000011204512
ryk / receptor-like tyrosine kinase / Q01887* / Tyrosine-protein kinase RYK *ENSDARG0000000723110


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR016244  Tyrosine-protein kinase, HGF/MSP receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0021549 cerebellum development IMP
 biological_processGO:0021587 cerebellum morphogenesis IMP
 biological_processGO:0021707 cerebellar granule cell differentiation IMP
 biological_processGO:0021953 central nervous system neuron differentiation IMP
 biological_processGO:0031017 exocrine pancreas development IMP
 biological_processGO:0033339 pectoral fin development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Sema4D mediated inhibition of cell attachment and migration
RAF/MAP kinase cascade
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3
NTRK2 activates RAC1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000017 endoderm endoderm decreased size , abnormal
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 ZFA:0000022 floor plate floor plate secondary motor neuron decreased amount , abnormal
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 ZFA:0000100 cerebellum cerebellum neuron decreased amount , abnormal
cerebellum apoptotic process increased occurrence , abnormal
cerebellum cerebellar granule cell decreased amount , abnormal
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 ZFA:0000123 liver liver decreased size , abnormal
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 ZFA:0000140 pancreas pancreas spheroid , abnormal
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 ZFA:0000563 pectoral fin musculature pectoral fin musculature decreased tonicity , abnormal
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 ZFA:0001094 whole organism whole organism curved ventral , abnormal
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 ZFA:0001161 pectoral fin pectoral fin morphology , abnormal
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 ZFA:0001372 pancreatic duct pancreatic duct morphology , abnormal
pancreatic duct cell migration disrupted , abnormal
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 ZFA:0009052 motor neuron motor neuron axon decreased length , abnormal
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 ZFA:0009243 CaP motoneuron CaP motoneuron axon decreased length , abnormal
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 ZFA:0009380 pancreatic ductal cell pancreatic ductal cell located in hepatic duct , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005318 stam2 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / O88811* / signal transducing adaptor molecule 2*  / complex / reaction
 ENSDARG00000035986 ptpn2b / protein tyrosine phosphatase, non-receptor type 2, b / PTPN2* / P17706* / Q06180* / protein tyrosine phosphatase, non-receptor type 2* / Tyrosine-protein phosphatase non-receptor type 2 *  / reaction
 ENSDARG00000028699 crkl / v-crk avian sarcoma virus CT10 oncogene homolog-like / P46109* / P47941* / Crk-like protein * / CRK like proto-oncogene, adaptor protein*  / reaction / complex
 ENSDARG00000062577 arhgap35a / Rho GTPase activating protein 35a / Q91YM2* / Q9NRY4* / ARHGAP35* / Rho GTPase activating protein 35*  / complex / reaction
 ENSDARG00000007923 ptpn1 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSDARG00000052928 arf6b / ADP-ribosylation factor 6b / ARF6* / P62330* / P62331* / ADP ribosylation factor 6*  / complex
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000060297 arhgap35b / Rho GTPase activating protein 35b / Q91YM2* / Q9NRY4* / ARHGAP35* / Rho GTPase activating protein 35*  / reaction / complex
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / reaction / complex
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / reaction / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000078216 eps15 / epidermal growth factor receptor pathway substrate 15 / P42566* / P42567* / Epidermal growth factor receptor substrate 15 *  / reaction / complex
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / reaction / complex
 ENSDARG00000020960 hgs / hepatocyte growth factor-regulated tyrosine kinase substrate / O14964* / hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 *  / reaction / complex
 ENSDARG00000016481 ptpn2a / protein tyrosine phosphatase, non-receptor type 2, a / PTPN2* / P17706* / Q06180* / protein tyrosine phosphatase, non-receptor type 2* / Tyrosine-protein phosphatase non-receptor type 2 *  / reaction
 ENSDARG00000002127 stam / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / P70297* / Q92783* / signal transducing adaptor molecule*  / complex / reaction
 ENSDARG00000062138 ranbp10 / RAN binding protein 10 / Q6VN20*  / reaction / complex
 ENSDARG00000086511 ptprjb.2 / protein tyrosine phosphatase, receptor type, Jb, tandem duplicate 2 / PTPRJ* / Q12913* / protein tyrosine phosphatase, receptor type J*  / reaction
 ENSDARG00000091539 ptprjb.1 / protein tyrosine phosphatase, receptor type, Jb, tandem duplicate 1 / PTPRJ* / Q12913* / protein tyrosine phosphatase, receptor type J*  / reaction
 ENSDARG00000033042 ptprja / protein tyrosine phosphatase, receptor type, J a / PTPRJ* / Q12913* / protein tyrosine phosphatase, receptor type J*  / reaction
 ENSDARG00000063719 usp8 / ubiquitin specific peptidase 8 / P40818* / Q80U87*  / reaction
 ENSDARG00000004218 rnd1b / Rho family GTPase 1b / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *  / reaction / complex
 ENSDARG00000075853 sh3kbp1 / SH3-domain kinase binding protein 1 / Q8R550* / Q96B97* / SH3 domain containing kinase binding protein 1*  / reaction / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000045544 hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction
 ENSDARG00000030547 rnd1a / Rho family GTPase 1a / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *  / complex / reaction
 ENSDARG00000023600 sh3gl2a / SH3 domain containing GRB2 like 2a, endophilin A1 / Q99962* / SH3GL2* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSDARG00000070903 met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / reaction
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000075625 lrig1 / leucine-rich repeats and immunoglobulin-like domains 1 / P70193* / Q96JA1* / Leucine-rich repeats and immunoglobulin-like domains protein 1 *  / complex / reaction
 ENSDARG00000098871 GGA3 (1 of many) / si:ch73-157i16.3 / GGA3* / Q9NZ52* / Q8BMI3* / ADP-ribosylation factor-binding protein GGA3 * / golgi associated, gamma adaptin ear containing, ARF binding protein 3*  / complex






 

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