ENSDARG00000020334


Danio rerio

Features
Gene ID: ENSDARG00000020334
  
Biological name :ptpn11a
  
Synonyms : protein tyrosine phosphatase, non-receptor type 11, a / ptpn11a
  
Possible biological names infered from orthology : P35235 / protein tyrosine phosphatase, non-receptor type 11 / PTPN11 / Q06124 / Tyrosine-protein phosphatase non-receptor type 11
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 3428194
Gene end: 3455639
  
Corresponding Affymetrix probe sets: Dr.20939.1.S1_at (Zebrafish Array)   Dr.20939.1.S2_at (Zebrafish Array)   Dr.26435.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000076040
Ensembl peptide - ENSDARP00000153169
swissprot - F1QZU5
ZFIN ID - ZDB-GENE-030131-5911
Ensembl - ENSDARG00000020334
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTPN11ENSGALG00000004821Gallus gallus
 PTPN11ENSG00000179295Homo sapiens
 P35235ENSMUSG00000043733Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ptpn11b / protein tyrosine phosphatase, non-receptor type 11, bENSDARG0000001234068
ptpn6 / protein tyrosine phosphatase, non-receptor type 6 / P29350* / P29351*ENSDARG0000008904353
ptprna / protein tyrosine phosphatase, receptor type, Na / PTPRN* / Q16849* / protein tyrosine phosphatase, receptor type N*ENSDARG0000005864623
ptprnb / protein tyrosine phosphatase, receptor type, Nb / PTPRN* / Q16849* / protein tyrosine phosphatase, receptor type N*ENSDARG0000007704723
ptprn2 / protein tyrosine phosphatase, receptor type, N polypeptide 2 / P80560* / Q92932* / protein tyrosine phosphatase, receptor type N2*ENSDARG0000003597021
ptpn5 / protein tyrosine phosphatase, non-receptor type 5 / P54829* / P54830* / Tyrosine-protein phosphatase non-receptor type 5 *ENSDARG0000007486620
ptprr / protein tyrosine phosphatase, receptor type, r / Q15256* / Q62132*ENSDARG0000010574420


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000980  SH2 domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR012152  Protein-tyrosine phosphatase, non-receptor type-6, -11
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003146 heart jogging IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 biological_processGO:0060028 convergent extension involved in axis elongation IMP
 biological_processGO:0060548 negative regulation of cell death IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IDA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
PI3K Cascade
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
PIP3 activates AKT signaling
Signaling by SCF-KIT
GAB1 signalosome
Downstream signal transduction
Tie2 Signaling
Costimulation by the CD28 family
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Interleukin-20 family signaling
MET activates PTPN11
Regulation of RUNX1 Expression and Activity
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium increased size , abnormal
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 ZFA:0000076 swim bladder swim bladder absent , abnormal
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 ZFA:0000107 eye eye increased distance eye , abnormal
eye edematous , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
heart malformed , abnormal
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 ZFA:0000200 dorsal root ganglion dorsal root ganglion neuron decreased amount , abnormal
dorsal root ganglion neuron displaced , abnormal
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 ZFA:0000295 trigeminal ganglion trigeminal ganglion decreased amount , abnormal
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 ZFA:0000944 posterior lateral line posterior lateral line neuron decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
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 ZFA:0001114 head head malformed , abnormal
head decreased size , abnormal
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 ZFA:0001117 post-vent region post-vent region curvature , abnormal
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 ZFA:0001155 enteric nervous system enteric nervous system neuron decreased amount , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage shape , abnormal
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 ZFA:0001458 cranial cartilage cranial cartilage morphology , abnormal
cranial cartilage malformed , abnormal
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 ZFA:0001555 epibranchial ganglion epibranchial ganglion decreased amount , abnormal
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 ZFA:0001576 sympathetic nervous system sympathetic nervous system neuron decreased amount , abnormal
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 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 structure , abnormal
pharyngeal arch 2 displaced , abnormal
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 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 structure , abnormal
pharyngeal arch 1 displaced , abnormal
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 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 aplastic , abnormal
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 ZFA:0001617 otolith otolith position , abnormal
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 ZFA:0009091 melanocyte melanocyte decreased amount , abnormal
melanocyte mislocalised , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000007356 fgf20a / fibroblast growth factor 20a / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*  / complex / reaction
 ENSDARG00000043317 kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*  / complex
 ENSDARG00000004782 fgfr3 / fibroblast growth factor receptor 3 / P22607*  / complex / reaction
 ENSDARG00000011027 fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*  / reaction / complex
 ENSDARG00000056133 kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*  / complex
 ENSDARG00000020625 jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSDARG00000030932 fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*  / reaction / complex
 ENSDARG00000052739 egf / epidermal growth factor / P01132* / P01133* / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000042723 gfra2a / GDNF family receptor alpha 2a / GFRA2* / O00451* / O08842* / GDNF family receptor alpha 2*  / complex / reaction
 ENSDARG00000011190 fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*  / reaction / complex
 ENSDARG00000043962 fgf18b / fibroblast growth factor 18b / FGF18* / O89101* / O76093* / fibroblast growth factor 18*  / reaction / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000104474 il6r / interleukin 6 receptor / P08887*  / complex / reaction
 ENSDARG00000100475 fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*  / complex / reaction
 ENSDARG00000045544 hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / reaction / complex
 ENSDARG00000059387 fgf7 / fibroblast growth factor 7 / P21781*  / complex / reaction
 ENSDARG00000028663 tek / TEK tyrosine kinase, endothelial / Q02763* / TEK receptor tyrosine kinase*  / complex / reaction
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / reaction / complex
 ENSDARG00000105120 gab2 / GRB2-associated binding protein 2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein family member 4*  / complex / reaction
 ENSDARG00000070903 met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / reaction
 ENSDARG00000067996 csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *  / reaction
 ENSDARG00000076510 fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*  / reaction / complex
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / reaction / complex
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / reaction / complex
 ENSDARG00000078688 frs3 / fibroblast growth factor receptor substrate 3 / O43559* / Q91WJ0*  / reaction / complex
 ENSDARG00000101540 fgf3 / P48802 / fibroblast growth factor 3 / P11487*  / reaction / complex
 ENSDARG00000075253 pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex
 ENSDARG00000055875 pag1 / phosphoprotein membrane anchor with glycosphingolipid microdomains 1 / Q3U1F9* / Q9NWQ8* / phosphoprotein associated with glycosphingolipid microdomains 1*  / reaction
 ENSDARG00000018060 pik3r2 / phosphoinositide-3-kinase, regulatory subunit 2 (beta) / O00459* / O08908* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulator...  / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000105033 BX897691.1 / BTLA* / Q7Z6A9* / B and T lymphocyte associated*  / complex / reaction
 ENSDARG00000069105 fgfr4 / fibroblast growth factor receptor 4 / P22455*  / complex / reaction
 ENSDARG00000104693 il6st / interleukin 6 signal transducer / P40189* / Q00560* / Interleukin-6 receptor subunit beta *  / reaction / complex
 ENSDARG00000086070 fgf20b / fibroblast growth factor 20b / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*  / complex / reaction
 ENSDARG00000076294 klb / klotho beta / Q86Z14* / Q99N32* / Beta-klotho *  / complex / reaction
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / reaction / complex
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction / complex
 ENSDARG00000102778 fgf17 / Q6SJP8 / fibroblast growth factor 17 / O60258* / P63075*  / complex / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / reaction / complex
 ENSDARG00000098663 fgf19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *  / complex / reaction
 ENSDARG00000044015 gfra2b / GDNF family receptor alpha 2b / GFRA2* / O00451* / O08842* / GDNF family receptor alpha 2*  / complex / reaction
 ENSDARG00000055305 ret / ret proto-oncogene receptor tyrosine kinase / P07949* / P35546* / ret proto-oncogene* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-...  / reaction / complex
 ENSDARG00000038139 pdgfbb / platelet-derived growth factor beta polypeptide b / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / reaction / complex
 ENSDARG00000079849 nrtn / neurturin / P97463* / Q99748*  / reaction / complex
 ENSDARG00000074582 gfra4b / GDNF family receptor alpha 4b / GFRA4* / Q9GZZ7* / Q9JJT2* / GDNF family receptor alpha 4*  / reaction / complex
 ENSDARG00000070494 pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...  / reaction / complex
 ENSDARG00000110069 pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*  / complex / reaction
 ENSDARG00000086778 pdgfba / platelet-derived growth factor beta polypeptide a / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / reaction / complex
 ENSDARG00000079862 kl / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / reaction / complex
 ENSDARG00000087704 gfra3 / GDNF family receptor alpha 3 / O35118* / O60609*  / complex / reaction
 ENSDARG00000087646 runx1 / runt-related transcription factor 1 / Q01196*  / reaction / complex
 ENSDARG00000020326 tyk2 / tyrosine kinase 2 / P29597*  / complex / reaction
 ENSDARG00000039959 gdnfa / glial cell derived neurotrophic factor a / GDNF* / P39905* / P48540* / glial cell derived neurotrophic factor* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), tra...  / reaction / complex
 ENSDARG00000099342 crfb15 / cytokine receptor family member B15 / Q08334* / IL10RB* / Gm21970* / interleukin 10 receptor subunit beta*  / complex / reaction






 

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