ENSDARG00000007356


Danio rerio

Features
Gene ID: ENSDARG00000007356
  
Biological name :fgf20a
  
Synonyms : fgf20a / fibroblast growth factor 20a
  
Possible biological names infered from orthology : FGF20 / fibroblast growth factor 20 / Q9ESL9 / Q9NP95
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 16393077
Gene end: 16394814
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000007295
NCBI entrez gene - 559630     See in Manteia.
swissprot - Q38PL0
ZFIN ID - ZDB-GENE-060110-1
Ensembl - ENSDARG00000007356
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGF20ENSGALG00000013663Gallus gallus
 FGF20ENSG00000078579Homo sapiens
 Fgf20ENSMUSG00000031603Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fgf20b / fibroblast growth factor 20b / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*ENSDARG0000008607081
fgf16 / Q2HXK8 / fibroblast growth factor 16 / O43320* / Q9ESL8*ENSDARG0000004223359
fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*ENSDARG0000007651032
fgf14 / fibroblast growth factor 14 / Q92915*ENSDARG0000004098231
fgf11b / fibroblast growth factor 11b / FGF11* / Q92914* / P70378* / fibroblast growth factor 11*ENSDARG0000004390731
fgf13a / fibroblast growth factor 13a / FGF13* / P70377* / Q92913* / fibroblast growth factor 13* / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA.*ENSDARG0000003505630
fgf13b / fibroblast growth factor 13b / FGF13* / P70377* / Q92913* / fibroblast growth factor 13* / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA.*ENSDARG0000005663330
fgf3 / P48802 / fibroblast growth factor 3 / P11487*ENSDARG0000010154030
fgf6b / fibroblast growth factor 6b / FGF6* / P21658* / P10767* / fibroblast growth factor 6*ENSDARG0000004585629
fgf4 / fibroblast growth factor 4 / P08620* / P11403*ENSDARG0000010523029
fgf11a / fibroblast growth factor 11a / FGF11* / Q92914* / P70378* / fibroblast growth factor 11*ENSDARG0000006966229
fgf5 / fibroblast growth factor 5 / P12034* / P15656*ENSDARG0000003537729
fgf9 / fibroblast growth factor 9ENSDARG0000007862529
fgf12a / fibroblast growth factor 12a / FGF12* / P61329* / P61328* / fibroblast growth factor 12*ENSDARG0000002795728
fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*ENSDARG0000010047528
fgf6a / fibroblast growth factor 6a / FGF6* / P21658* / P10767* / fibroblast growth factor 6*ENSDARG0000000935128
fgf12b / fibroblast growth factor 12b / FGF12* / P61328* / fibroblast growth factor 12*ENSDARG0000011352527
fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*ENSDARG0000003093227
fgf7 / fibroblast growth factor 7 / P21781*ENSDARG0000005938723


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0046850 regulation of bone remodeling IMP
 biological_processGO:0060249 anatomical structure homeostasis IMP
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000108 fin fin quality , abnormal
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 ZFA:0000270 maxilla maxilla malformed , abnormal
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 ZFA:0000277 scale scale malformed , abnormal
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 ZFA:0000407 pectoral girdle pectoral girdle alignment pectoral fin , abnormal
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 ZFA:0000486 parietal bone parietal bone malformed , abnormal
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 ZFA:0000561 parasphenoid parasphenoid malformed , abnormal
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 ZFA:0000567 premaxilla premaxilla malformed , abnormal
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 ZFA:0000863 dermatocranium dermatocranium ossification involved in bone remodeling decreased occurrence , abnormal
dermatocranium bone resorption increased occurrence , abnormal
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 ZFA:0001058 caudal fin caudal fin decreased length , abnormal
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 ZFA:0001269 regenerating fin regenerating fin decreased amount , abnormal
regenerating fin decreased length , abnormal
regenerating fin length , ameliorated
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 ZFA:0001270 blastema blastema quality , abnormal
blastema aplastic , abnormal
blastema absent , abnormal
blastema cell proliferation decreased occurrence , abnormal
blastema cell proliferation occurrence , ameliorated
Show

 ZFA:0005448 preopercular sensory canal preopercular sensory canal malformed , abnormal
Show

 ZFA:0005472 inter-frontal joint inter-frontal joint branched , abnormal
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 ZFA:0005606 cranial vault cranial vault malformed , abnormal
cranial vault bone resorption increased occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000078688 frs3 / fibroblast growth factor receptor substrate 3 / O43559* / Q91WJ0*  / complex / reaction
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / reaction / complex
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000102778 fgf17 / Q6SJP8 / fibroblast growth factor 17 / O60258* / P63075*  / complex / reaction
 ENSDARG00000007356 fgf20a / fibroblast growth factor 20a / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*  / reaction / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / reaction
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction / complex
 ENSDARG00000004782 fgfr3 / fibroblast growth factor receptor 3 / P22607*  / reaction / complex
 ENSDARG00000043962 fgf18b / fibroblast growth factor 18b / FGF18* / O89101* / O76093* / fibroblast growth factor 18*  / complex / reaction
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000086070 fgf20b / fibroblast growth factor 20b / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / complex / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / reaction / complex






 

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