ENSDARG00000100475


Danio rerio

Features
Gene ID: ENSDARG00000100475
  
Biological name :fgf10b
  
Synonyms : fgf10b / fibroblast growth factor 10b
  
Possible biological names infered from orthology : FGF10 / fibroblast growth factor 10 / O15520 / O35565
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 8769069
Gene end: 8817841
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000147637
Ensembl peptide - ENSDARP00000140311
NCBI entrez gene - 751792     See in Manteia.
RefSeq - NM_001045858
RefSeq Peptide - NP_001039323
swissprot - A0A0R4ITI2
swissprot - Q1XG75
ZFIN ID - ZDB-GENE-060828-1
Ensembl - ENSDARG00000100475
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGF10ENSGALG00000014872Gallus gallus
 FGF10ENSG00000070193Homo sapiens
 Fgf10ENSMUSG00000021732Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*ENSDARG0000003093259
fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*ENSDARG0000007651048
fgf3 / P48802 / fibroblast growth factor 3 / P11487*ENSDARG0000010154037
fgf7 / fibroblast growth factor 7 / P21781*ENSDARG0000005938735
fgf20b / fibroblast growth factor 20b / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*ENSDARG0000008607032
fgf20a / fibroblast growth factor 20a / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*ENSDARG0000000735630
fgf6b / fibroblast growth factor 6b / FGF6* / P21658* / P10767* / fibroblast growth factor 6*ENSDARG0000004585629
fgf6a / fibroblast growth factor 6a / FGF6* / P21658* / P10767* / fibroblast growth factor 6*ENSDARG0000000935129
fgf16 / Q2HXK8 / fibroblast growth factor 16 / O43320* / Q9ESL8*ENSDARG0000004223329
fgf5 / fibroblast growth factor 5 / P12034* / P15656*ENSDARG0000003537728
fgf4 / fibroblast growth factor 4 / P08620* / P11403*ENSDARG0000010523026
fgf13b / fibroblast growth factor 13b / FGF13* / P70377* / Q92913* / fibroblast growth factor 13* / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA.*ENSDARG0000005663326
fgf13a / fibroblast growth factor 13a / FGF13* / P70377* / Q92913* / fibroblast growth factor 13* / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA.*ENSDARG0000003505625
fgf12b / fibroblast growth factor 12b / FGF12* / P61328* / fibroblast growth factor 12*ENSDARG0000011352524
fgf9 / fibroblast growth factor 9ENSDARG0000007862524
fgf14 / fibroblast growth factor 14 / Q92915*ENSDARG0000004098223
fgf12a / fibroblast growth factor 12a / FGF12* / P61329* / P61328* / fibroblast growth factor 12*ENSDARG0000002795722
fgf11b / fibroblast growth factor 11b / FGF11* / Q92914* / P70378* / fibroblast growth factor 11*ENSDARG0000004390721
fgf11a / fibroblast growth factor 11a / FGF11* / Q92914* / P70378* / fibroblast growth factor 11*ENSDARG0000006966220


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028252  Fibroblast growth factor 10


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0071599 otic vesicle development IGI
 biological_processGO:0071696 ectodermal placode development IGI
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR1b ligand binding and activation
FGFR2b ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
Show

 ZFA:0000123 liver liver decreased size , abnormal
liver right side of gut , abnormal
Show

 ZFA:0000140 pancreas pancreas left side of gut , abnormal
Show

 ZFA:0001094 whole organism whole organism curved ventral , abnormal
Show

 ZFA:0001249 exocrine pancreas exocrine pancreas decreased length , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011027 fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSDARG00000030932 fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*  / complex / reaction
 ENSDARG00000011190 fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / reaction / complex
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000032617 fgfrl1a / fibroblast growth factor receptor like 1a / Q91V87* / FGFRL1* / Q8N441* / fibroblast growth factor receptor like 1*  / reaction / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction / complex
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / reaction
 ENSDARG00000076510 fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / reaction / complex
 ENSDARG00000059387 fgf7 / fibroblast growth factor 7 / P21781*  / complex
 ENSDARG00000078688 frs3 / fibroblast growth factor receptor substrate 3 / O43559* / Q91WJ0*  / reaction / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000105230 fgf4 / fibroblast growth factor 4 / P08620* / P11403*  / complex / reaction
 ENSDARG00000091660 fgfbp1b / fibroblast growth factor binding protein 1b / FGFBP1* / Q14512* / fibroblast growth factor binding protein 1*  / reaction / complex
 ENSDARG00000079355 flrt2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *  / reaction / complex
 ENSDARG00000097299 flrt2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *  / reaction / complex
 ENSDARG00000075597 flrt1b / fibronectin leucine rich transmembrane protein 1b / FLRT1* / Q6RKD8* / Q9NZU1* / fibronectin leucine rich transmembrane protein 1* / Leucine-rich repeat transmembrane protein FLRT1 *  / reaction / complex
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000076895 flrt3 / fibronectin leucine rich transmembrane 3 / Q8BGT1* / Q9NZU0* / fibronectin leucine rich transmembrane protein 3* / Leucine-rich repeat transmembrane protein FLRT3 *  / complex / reaction
 ENSDARG00000100475 fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*  / complex / reaction
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / reaction
 ENSDARG00000039963 fgfbp1b / fibroblast growth factor binding protein 1b / Q14512* / FGFBP1* / O70514* / fibroblast growth factor binding protein 1*  / reaction / complex
 ENSDARG00000101540 fgf3 / P48802 / fibroblast growth factor 3 / P11487*  / reaction / complex






 

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