ENSDARG00000075597


Danio rerio

Features
Gene ID: ENSDARG00000075597
  
Biological name :flrt1b
  
Synonyms : fibronectin leucine rich transmembrane protein 1b / flrt1b
  
Possible biological names infered from orthology : fibronectin leucine rich transmembrane protein 1 / FLRT1 / Leucine-rich repeat transmembrane protein FLRT1 / Q6RKD8 / Q9NZU1
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 45883687
Gene end: 45932399
  
Corresponding Affymetrix probe sets: Dr.15197.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000098497
Ensembl peptide - ENSDARP00000151576
NCBI entrez gene - 100144397     See in Manteia.
swissprot - F1QF54
ZFIN ID - ZDB-GENE-080327-6
Ensembl - ENSDARG00000075597
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FLRT1ENSG00000126500Homo sapiens
 Flrt1ENSMUSG00000047787Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
flrt3 / fibronectin leucine rich transmembrane 3 / Q8BGT1* / Q9NZU0* / fibronectin leucine rich transmembrane protein 3* / Leucine-rich repeat transmembrane protein FLRT3 *ENSDARG0000007689544
flrt2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *ENSDARG0000007935535
flrt2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *ENSDARG0000009729932
omgb / oligodendrocyte myelin glycoprotein b / OMG* / P23515* / oligodendrocyte myelin glycoprotein*ENSDARG0000008944412
si:dkey-90m5.4 / LRG1* / P02750* / leucine rich alpha-2-glycoprotein 1*ENSDARG0000002938811
si:ch211-191d15.2 / Nepn* / Q9CQ76* / Nephrocan *ENSDARG0000009283410
omga / oligodendrocyte myelin glycoprotein a / OMG* / P23515* / oligodendrocyte myelin glycoprotein*ENSDARG000000865739


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Downstream signaling of activated FGFR1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism viability , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011027 fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*  / reaction / complex
 ENSDARG00000030932 fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*  / complex / reaction
 ENSDARG00000011190 fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*  / reaction / complex
 ENSDARG00000076510 fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*  / complex / reaction
 ENSDARG00000079862 kl / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / reaction / complex
 ENSDARG00000100475 fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*  / reaction / complex
 ENSDARG00000101540 fgf3 / P48802 / fibroblast growth factor 3 / P11487*  / complex / reaction






 

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