ENSDARG00000079862


Danio rerio

Features
Gene ID: ENSDARG00000079862
  
Biological name :kl
  
Synonyms : kl / klotho
  
Possible biological names infered from orthology : Klotho Klotho peptide / O35082 / Q9UEF7
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 34001444
Gene end: 34026125
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000100445
Ensembl peptide - ENSDARP00000124944
Ensembl peptide - ENSDARP00000148269
NCBI entrez gene - 562316     See in Manteia.
swissprot - F1RC43
ZFIN ID - ZDB-GENE-110221-1
Ensembl - ENSDARG00000079862
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KLENSGALG00000017068Gallus gallus
 KLENSG00000133116Homo sapiens
 KlENSMUSG00000058488Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
klb / klotho beta / Q86Z14* / Q99N32* / Beta-klotho *ENSDARG0000007629439
lct / lactase / P09848*ENSDARG0000006067138
si:dkey-79p17.3 / LCT* / P09848* / lactase*ENSDARG0000009240438
lctlb / lactase-like b / LCTL* / Q6UWM7* / lactase like*ENSDARG0000001633720
lctla / lactase-like a / LCTL* / Q6UWM7* / Q8K1F9* / lactase like* / Lactase-like protein *ENSDARG0000003613919
gba3 / glucosidase, beta, acid 3 (gene/pseudogene) / glucosylceramidase beta 3 (gene/pseudogene)*ENSDARG0000003115016


Protein motifs (from Interpro)
Interpro ID Name
 IPR001360  Glycoside hydrolase family 1
 IPR017853  Glycoside hydrolase superfamily
 IPR028546  Klotho


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR1c and Klotho ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
Negative regulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011027 fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSDARG00000011190 fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSDARG00000045873 frs2a / fibroblast growth factor receptor substrate 2a / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction / complex
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / reaction
 ENSDARG00000078688 frs3 / fibroblast growth factor receptor substrate 3 / O43559* / Q91WJ0*  / reaction / complex
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / complex / reaction
 ENSDARG00000097299 flrt2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *  / reaction / complex
 ENSDARG00000075597 flrt1b / fibronectin leucine rich transmembrane protein 1b / FLRT1* / Q6RKD8* / Q9NZU1* / fibronectin leucine rich transmembrane protein 1* / Leucine-rich repeat transmembrane protein FLRT1 *  / complex / reaction
 ENSDARG00000079862 kl / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / complex / reaction
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000038225 nras / NRAS proto-oncogene, GTPase / P01111* / neuroblastoma ras oncogene*  / reaction
 ENSDARG00000037353 frs2b / fibroblast growth factor receptor substrate 2b / FRS2* / Q8C180* / Q8WU20* / fibroblast growth factor receptor substrate 2*  / complex / reaction
 ENSDARG00000037018 gab1 / GRB2-associated binding protein 1 / Q13480* / Q9QYY0*  / complex / reaction
 ENSDARG00000076895 flrt3 / fibronectin leucine rich transmembrane 3 / Q8BGT1* / Q9NZU0* / fibronectin leucine rich transmembrane protein 3* / Leucine-rich repeat transmembrane protein FLRT3 *  / complex / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000079355 flrt2 / fibronectin leucine rich transmembrane protein 2 / O43155* / Q8BLU0* / Leucine-rich repeat transmembrane protein FLRT2 *  / reaction / complex






 

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